Long RP tachycardia with a paradoxical response to para‐Hisian pacing

2019 ◽  
Vol 30 (6) ◽  
pp. 981-983
Author(s):  
Reginald T. Ho ◽  
Jonathan P. Logue
Keyword(s):  
Paradoxical Response

scholarly journals Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ditte Olsen ◽  
Niels Wellner ◽  
Mathias Kaas ◽  
Inge E. M. de Jong ◽  
Florence Sotty ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Firing Pattern ◽  
Neurodevelopmental Disorder ◽  
Paradoxical Response ◽  
Dopaminergic Transmission ◽  
Hyperactivity Disorder ◽  
Responses To Dopamine ◽  
Circuit Function ◽  
Underlying Pathophysiology

AbstractAttention deficit hyperactivity disorder (ADHD) is the most frequently diagnosed neurodevelopmental disorder worldwide. Affected individuals present with hyperactivity, inattention, and cognitive deficits and display a characteristic paradoxical response to drugs affecting the dopaminergic system. However, the underlying pathophysiology of ADHD and how this relates to dopaminergic transmission remains to be fully understood. Sorcs2−/− mice uniquely recapitulate symptoms reminiscent of ADHD in humans. Here, we show that lack of SorCS2 in mice results in lower sucrose intake, indicating general reward deficits. Using in-vivo recordings, we further find that dopaminergic transmission in the ventral tegmental area (VTA) is shifted towards a more regular firing pattern with marked reductions in the relative occurrence of irregular firing in Sorcs2−/− mice. This was paralleled by abnormal acute behavioral responses to dopamine receptor agonists, suggesting fundamental differences in dopaminergic circuits and indicating a perturbation in the balance between the activities of the postsynaptic dopamine receptor DRD1 and the presynaptic inhibitory autoreceptor DRD2. Interestingly, the hyperactivity and drug response of Sorcs2−/− mice were markedly affected by novelty. Taken together, our findings show how loss of a candidate ADHD-risk gene has marked effects on dopaminergic circuit function and the behavioral response to the environment.

Paradoxical response preceding control ofScedosporium apiospermummycetoma with posaconazole treatment

2015 ◽  
Vol 47 (11) ◽  
pp. 830-833 ◽  
Author(s):  
Guillaume Béraud ◽  
Nicole Desbois ◽  
Caroline Coyo ◽  
Danièle Quist ◽  
Benoit Rozé ◽  
...  
Keyword(s):  
Paradoxical Response

Paradoxical Response to Dexamethasone in the Diagnosis of Primary Pigmented Nodular Adrenocortical Disease

1999 ◽  
Vol 131 (8) ◽  
pp. 585 ◽  
Author(s):  
Constantine A. Stratakis ◽  
Nicholas Sarlis ◽  
Lawrence S. Kirschner ◽  
J. Aidan Carney ◽  
John L. Doppman ◽  
...  
Keyword(s):  
Paradoxical Response

scholarly journals Paradoxical Reaction to Alprazolam in an Elderly Woman with a History of Anxiety, Mood Disorders, and Hypothyroidism

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Daniel Kirkpatrick ◽  
Tyler Smith ◽  
Mitchell Kerfeld ◽  
Taylor Ramsdell ◽  
Hasnain Sadiq ◽  
...  
Keyword(s):  
Case Report ◽  
Elderly Woman ◽  
Temporal Relationship ◽  
Bilateral Mastectomy ◽  
Subjective Feeling ◽  
Paradoxical Reaction ◽  
Paradoxical Response ◽  
Appropriate Treatment ◽  
History Of ◽  
Motor Restlessness

With less than 1% of patients who use benzodiazepines being affected, paradoxical responses to benzodiazepines are rare. In this case report, we outline the course of an 80-year-old female who developed a paradoxical response to benzodiazepines. Significant medical and psychiatric history includes anxiety, mood disorder, hypothyroidism, bilateral mastectomy, goiter removal, and triple bypass. The patient presented with mental status changes, anxiety, motor restlessness, and paranoia. Over time, a temporal relationship between the severity of the patient’s motor agitation and intake of alprazolam was observed. As doses of alprazolam were decreased, her motor agitation became less severe. In addition to motor agitation, the patient also demonstrated increased aggressiveness, a subjective feeling of restlessness, and increased talkativeness. As her dose of alprazolam decreased, many of the patient’s symptoms were observed to decrease. This case report also discusses theories regarding the pathophysiology of paradoxical reactions to benzodiazepines, known risk factors, and appropriate treatment.

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