Unipolar Voltage Abnormality is Associated with Greater Left Ventricular Dysfunction in Ischemic Cardiomyopathy

2013 ◽  
Vol 25 (3) ◽  
pp. 293-298 ◽  
Author(s):  
BASHAR ALDHOON ◽  
DAVID S. FRANKEL ◽  
MATHEW D. HUTCHINSON ◽  
DAVID J. CALLANS ◽  
ANDREW E. EPSTEIN ◽  
...  
Keyword(s):  
Left Ventricular Dysfunction ◽  
Ischemic Cardiomyopathy ◽  
Ventricular Dysfunction ◽  
Left Ventricular

scholarly journals Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Georg D. Duerr ◽  
Daniela Dewald ◽  
Eva J. Schmitz ◽  
Luise Verfuerth ◽  
Katharina Keppel ◽  
...  
Keyword(s):  
Antioxidative Enzymes ◽  
Left Ventricular Dysfunction ◽  
Ischemic Cardiomyopathy ◽  
Ventricular Dysfunction ◽  
Interstitial Fibrosis ◽  
Myosin Heavy Chain Isoforms ◽  
Left Ventricular ◽  
Adverse Remodeling ◽  
Cardioprotective Effects

Aims. Repetitive brief ischemia and reperfusion (I/R) is associated with left ventricular dysfunction during development of ischemic cardiomyopathy. We investigated the role of zinc-donor proteins metallothionein MT1 and MT2 in a closed-chest murine model ofI/R.Methods. Daily 15-minute LAD-occlusion was performed for 1, 3, and 7 days in SV129 (WT)- and MT1/2 knockout (MT-/-)-mice (n= 8–10/group). Hearts were examined with M-mode echocardiography and processed for histological and mRNA studies.Results. Expression of MT1/2 mRNA was transiently induced during repetitiveI/Rin WT-mice, accompanied by a transient inflammation, leading to interstitial fibrosis with left ventricular dysfunction without infarction. In contrast, MT-/--hearts presented with enhanced apoptosis and small infarctions leading to impaired global and regional pump function. Molecular analysis revealed maladaptation of myosin heavy chain isoforms and antioxidative enzymes in MT1/2-/--hearts. Despite their postponed chemokine induction we found a higher total neutrophil density and macrophage infiltration in small infarctions in MT-/--hearts. Subsequently, higher expression of osteopontin 1 and tenascin C was associated with increased myofibroblast density resulting in predominately nonreversible fibrosis and adverse remodeling in MT1/2-/--hearts.Conclusion. Cardioprotective effects of MT1/2 seem to be exerted via modulation of contractile elements, antioxidative enzymes, inflammatory response, and myocardial remodeling.

Noninvasive, quantitative identification of left ventricular dysfunction in ischemic cardiomyopathy

2000 ◽  
Vol 191 (4) ◽  
pp. S76
Author(s):  
Randall P Scheri ◽  
Pavlos Moustakidis ◽  
Brian P Cupps ◽  
Andrew M Kates ◽  
Robert J Gropler ◽  
...  
Keyword(s):  
Left Ventricular Dysfunction ◽  
Ischemic Cardiomyopathy ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Quantitative Identification
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