Selective microembolization of the circumflex coronary artery in an ovine model: dilated, ischemic cardiomyopathy and left ventricular dysfunction

2004 ◽  
Vol 10 (2) ◽  
pp. 174-183 ◽  
Author(s):  
Gretel Monreal ◽  
Mark A Gerhardt ◽  
Atsushi Kambara ◽  
A.Reza Abrishamchian ◽  
John A Bauer ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Left Ventricular Dysfunction ◽  
Ischemic Cardiomyopathy ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Ovine Model ◽  
Circumflex Coronary Artery

scholarly journals Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction

2011 ◽  
Vol 364 (17) ◽  
pp. 1607-1616 ◽  
Author(s):  
Eric J. Velazquez ◽  
Kerry L. Lee ◽  
Marek A. Deja ◽  
Anil Jain ◽  
George Sopko ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Left Ventricular Dysfunction ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Ventricular Dysfunction ◽  
Artery Bypass ◽  
Left Ventricular

Unipolar Voltage Abnormality is Associated with Greater Left Ventricular Dysfunction in Ischemic Cardiomyopathy

2013 ◽  
Vol 25 (3) ◽  
pp. 293-298 ◽  
Author(s):  
BASHAR ALDHOON ◽  
DAVID S. FRANKEL ◽  
MATHEW D. HUTCHINSON ◽  
DAVID J. CALLANS ◽  
ANDREW E. EPSTEIN ◽  
...  
Keyword(s):  
Left Ventricular Dysfunction ◽  
Ischemic Cardiomyopathy ◽  
Ventricular Dysfunction ◽  
Left Ventricular

scholarly journals Coronary Artery Bypass Surgery in Patients with Left Ventricular Dysfunction

2012 ◽  
Vol 56 (1) ◽  
pp. 9-10
Author(s):  
Eric J. Velazquez ◽  
Kerry L. Lee ◽  
Marek A. Deja ◽  
Anil Jain ◽  
George Sopko ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Left Ventricular Dysfunction ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Ventricular Dysfunction ◽  
Artery Bypass ◽  
Left Ventricular

scholarly journals Impact of Renin-Angiotensin-Aldosterone System Gene Polymorphisms on Left Ventricular Dysfunction in Coronary Artery Disease Patients

2012 ◽  
Vol 32 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Avshesh Mishra ◽  
Anshika Srivastava ◽  
T. Mittal ◽  
N. Garg ◽  
B. Mittal
Keyword(s):  
Coronary Artery Disease ◽  
Cardiac Output ◽  
Coronary Artery ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
P Value ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Artery Disease

Background: Left ventricular dysfunction (LVD), followed by fall in cardiac output is one of the major complications in some coronary artery disease (CAD) patients. The decreased cardiac output over time leads to activation of the renin-angiotensin-aldosterone system which results in vasoconstriction by influencing salt-water homeostasis. Therefore, the purpose of the present study was to explore the association of single nucleotide polymorphisms (SNPs) in angiotensin I converting enzyme;ACE(rs4340), angiotensin II type1 receptor; AT1 (rs5186) and aldosterone synthase;CYP11B2(rs1799998) with LVD.Methods and results: The present study was carried out in two cohorts. The primary cohort included 308 consecutive patients with angiographically confirmed CAD and 234 healthy controls. Among CAD, 94 with compromised left ventricle ejection fraction (LVEF ≤ 45) were categorized as LVD. The ACE I/D, AT1 A1166C andCYP11B2T-344C polymorphisms were determined by PCR. Our results showed that ACE I/D was significantly associated with CAD but not with LVD. However, AT1 1166C variant was significantly associated with LVD (LVEF ≤ 45) (p value=0.013; OR=3.69), butCYP11B2(rs1799998) was not associated with either CAD or LVD. To validate our results, we performed a replication study in additional 200 cases with similar clinical characteristics and results again confirmed consistent findings (p value=0.020; OR=5.20).Conclusion: AT1 A1166C plays important role in conferring susceptibility of LVD.

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