Genome‐wide association study for plasma very low‐density lipoprotein concentration in chicken

2019 ◽  
Vol 136 (5) ◽  
pp. 351-361
Author(s):  
Hui Zhang ◽  
Linyong Shen ◽  
Yumao Li ◽  
Zichun Xu ◽  
Xinyang Zhang ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Genome Wide Association ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Genome Wide ◽  
Lipoprotein Concentration

scholarly journals Genome-Wide Association Study of lipid traits in youth with type 2 diabetes

2021 ◽  
Author(s):  
Nicola Santoro ◽  
Ling Chen ◽  
Jennifer Todd ◽  
Jasmin Divers ◽  
Amy S Shah ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Risk Allele ◽  
Density Lipoprotein ◽  
Genome Wide Association ◽  
Relationship Matrix ◽  
Genome Wide ◽  
A Genome

Abstract Context Dyslipidemia is highly prevalent in youth with type 2 diabetes (T2D), yet the pathogenic components of dyslipidemia in youth with T2D are poorly understood. Objective To evaluate the genetic determinants of lipid traits in youth with T2D through a genome-wide association study (GWAS). Design, participants and main outcome measures We genotyped 206,928 variants and imputed 17,642,824 variants in 1,076 youth (mean age 15.0 ±2.48 years) with T2D from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) and SEARCH for Diabetes in Youth (SEARCH) studies as part of the Progress in Diabetes Genetics in Youth (ProDiGY) consortium. We performed association testing for triglyceride, low-density lipoprotein (LDL-c) and high-density lipoprotein (HDL-c) concentrations adjusted for the genetic relationship matrix within each sub-study followed by meta-analyses for each trait. Results We identified a novel association between a deletion on chromosome 3 (3:67817380_AT/A_Deletion:RP11-81N13.1) and triglyceride levels at genome-wide level of significance (P=2.3×10 -8) with each risk allele increasing triglycerides by 20%. We also identified a genome-wide significant signal at rs247617 (P=5.1×10 -9) between HERFUD1 and CETP associated with HDL-c, with carriers of one copy of the risk allele having twice higher HDL-c. Conclusions Our genetic analyses of lipid traits in youth with T2D have identified one novel and one previously known locus. Additional studies are needed to further characterize the genetic architecture of dyslipidemia in youth with T2D.

Correlates of plasma very-low-density lipoprotein concentration and composition in premenopausal women

Metabolism ◽  
1990 ◽  
Vol 39 (6) ◽  
pp. 577-583 ◽  
Author(s):  
Jean-Pierre Després ◽  
Sital Moorjani ◽  
Marie-Christine Pouliot ◽  
Angelo Tremblay ◽  
André Nadeau ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Premenopausal Women ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Concentration
Sign in / Sign up

Export Citation Format

Share Document