Inhibition of morphological transition and hyphae extension in Candida spp. by occidiofungin

2021 ◽  
Author(s):  
Rabina Kumpakha ◽  
Donna M. Gordon
Keyword(s):  
Morphological Transition ◽  
Candida Spp

scholarly journals Virulence of Clinical Candida Isolates

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 466
Author(s):  
Martyna Mroczyńska ◽  
Anna Brillowska-Dąbrowska
Keyword(s):  
Virulence Factors ◽  
Biofilm Formation ◽  
Galleria Mellonella ◽  
Hydrolytic Enzymes ◽  
Morphological Transition ◽  
Candida Spp

The factors enabling Candida spp. infections are secretion of hydrolytic enzymes, adherence to surfaces, biofilm formation or morphological transition, and fitness attributes. The aim of this study was to investigate the correlation between known extracellular virulence factors and survival of Galleria mellonella larvae infected with clinical Candida. The 25 isolates were tested and the activity of proteinases among 24/24, phospholipases among 7/22, esterases among 14/23, hemolysins among 18/24, and biofilm formation ability among 18/25 isolates was confirmed. Pathogenicity investigation using G. mellonella larvae as host model demonstrated that C. albicans isolates and C. glabrata isolate were the most virulent and C. krusei isolates were avirulent. C. parapsilosis virulence was identified as varied, C. inconspicua were moderately virulent, and one C. palmioleophila isolate was of low virulence and the remaining isolates of this species were moderately virulent. According to our study, virulence of Candida isolates is related to the expression of proteases, hemolysins, and esterases.

scholarly journals Catheterized-bladder environment induces hyphal Candida albicans formation, promoting fungal colonization and persistence.

2021 ◽  
Author(s):  
Alyssa A La Bella ◽  
Marissa J. Andersen ◽  
Alex Molesan ◽  
Peter V Stuckey ◽  
Felipe H Santiago-Tirado ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Urinary Catheter ◽  
Public Health Problem ◽  
Fungal Colonization ◽  
Invasive Infection ◽  
Morphological Transition ◽  
Candida Spp ◽  
Poor Understanding ◽  
Tract Infections ◽  
Hospital Acquired

Catheter-associated urinary tract infections (CAUTIs) are a serious public health problem and account for approximately 40% of hospital-acquired infections worldwide. Candida spp are a major causative agent of CAUTI (17.8%) – specifically Candida albicans – that has steadily increased to become the second most common CAUTI uropathogen 1 . Yet, there is poor understanding of the molecular details of how C. albicans attaches, grows in the bladder, forms biofilms, survives, and persists during CAUTI 2 . Understanding of the mechanisms that contribute to CAUTI and invasive fungal infection will give insights into the development of more effective therapies, which are needed due to the spread of antifungal resistance and complex management of CAUTI in patients that require a urinary catheter 3 . Here, we characterize the ability of five Candida albicans clinical and laboratory strains to colonize the urinary catheter, grow and form biofilm in urine, and their ability to cause CAUTIs using our mouse model. Analysis of C. albicans strains revealed that growth in urine promotes morphological transition from yeast to hyphae, which is important for invasive infection. Additionally, we found that biofilm formation was dependent on the presence of fibrinogen, a protein released on the bladder to promote bladder healing 4,5 . Furthermore, deletion of hyphae regulatory genes resulted in defective bladder and catheter colonization and abolished dissemination. These results indicate that novel antifungal therapies preventing the morphological transition of C. albicans from yeast to hyphae have considerable promise for the treatment of fungal CAUTIs.

Candida spp. en la microbiota intestinal de las personas con autismo: revisión sistemática

2019 ◽  
Vol 68 (01) ◽  
pp. 1
Author(s):  
Pedro Andreo Martínez ◽  
Nuria García Martínez ◽  
Joaquín Quesada Medina ◽  
Elvira Pilar Sánchez Samper ◽  
Agustín Ernesto Martínez González
Keyword(s):  
Candida Spp ◽  
Revisión Sistemática

The effect of some chemical materials against virulence factors of Candida ssp isolated from UTI patients

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Fatima Abdul Hussein Mejbel
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Virulence Factors ◽  
Biofilm Formation ◽  
Germ Tube ◽  
Laboratory Culture ◽  
Candida Spp ◽  
Other Substances ◽  
Chemical Materials

 During the period from September 2016 to December 2017,135 urine samples were collected from urinary tract infection patients attending to AL-Zahraa Hospital in AL-Najaf Governorate. The present study was conducted to isolate and identify Candida spp. isolated from urinary tract infection patients by different methods including direct examination, laboratory culture, biochemical test and by modern techniques (Api Candida kit) and determine the virulence factors phenotypic to Candida spp which involved (biofilm formation,phospholipase and germ tube). The percentage of females to males was as following, female (84) 62.2 % (21) infected and male (51) 37.8% (1) infected with all age categories. The results in this study are explain that is some Candida spp. such as C. albicans, have high susceptible to eugenole follow by phenol and umbellulone. The efficiency of some chemical substances such as (eugenole,umbellulone, and phenol) was evaluated to inhibit the growth of Candida ssp as well as some virulence factors such as biofilm formation,germ tube and phospholipase,which were studied in this research. Statistically analysis results have been significance difference between the results of the substance concentrations and the concentrations of the different other substances.

THE EFFECT OF CHLOROPHYLLIPTUM SOLUTION ON THE ADHESIVENESS OF CANDIDA SPP.

2019 ◽  
Vol 15 (68) ◽  
pp. 167
Author(s):  
M. M. Ananieva ◽  
M. O. Faustova ◽  
L. M. Sizova ◽  
R. O. Reva
Keyword(s):  
Candida Spp
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