Oral administration of Hsp65‐producing Lactococcus lactis attenuates allergic asthma in a murine model

2020 ◽  
Author(s):  
L.B. Lacerda ◽  
W.M. Rios ◽  
A.P. Masson ◽  
I.T. Brandão ◽  
T.M. Milani ◽  
...  
Keyword(s):  
Oral Administration ◽  
Allergic Asthma ◽  
Lactococcus Lactis ◽  
Murine Model

Milk Fermented with a 15-Lipoxygenase-1-Producing Lactococcus Lactis Alleviates Symptoms of colitis in a Murine Model

2015 ◽  
Vol 16 (5) ◽  
pp. 424-429 ◽  
Author(s):  
Tessalia Saraiva ◽  
Katia Morais ◽  
Vanessa Pereira ◽  
Marcela Azevedo ◽  
Clarissa Rocha ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Murine Model

Epicutaneous immune modulation with Bet v 1 plus R848 suppresses allergic asthma in a murine model

Allergy ◽  
2013 ◽  
Vol 69 (3) ◽  
pp. 328-337 ◽  
Author(s):  
S. Siebeneicher ◽  
S. Reuter ◽  
M. Krause ◽  
A. Wangorsch ◽  
J. Maxeiner ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Murine Model ◽  
Immune Modulation ◽  
Bet V 1

scholarly journals Rotavirus VP6 protein mucosally delivered by cell wall-derived particles from Lactococcus lactis induces protection against infection in a murine model

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0203700 ◽  
Author(s):  
C. Facundo Temprana ◽  
Marcelo H. Argüelles ◽  
Nicolás M. Gutierrez ◽  
Patricia A. Barril ◽  
Laura E. Esteban ◽  
...  
Keyword(s):  
Cell Wall ◽  
Lactococcus Lactis ◽  
Murine Model ◽  
Protection Against Infection ◽  
Rotavirus Vp6

Ameliorative effects of Artemisia pallens in a murine model of ovalbumin-induced allergic asthma via modulation of biochemical perturbations

2017 ◽  
Vol 94 ◽  
pp. 880-889 ◽  
Author(s):  
Anwesha A. Mukherjee ◽  
Amit D. Kandhare ◽  
Supada R. Rojatkar ◽  
Subhash L. Bodhankar
Keyword(s):  
Allergic Asthma ◽  
Murine Model ◽  
Artemisia Pallens

scholarly journals Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Yao-Tung Wang ◽  
Hsu-Chung Liu ◽  
Hui-Chen Chen ◽  
Yen-Ching Lee ◽  
Tung-Chou Tsai ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Oral Immunotherapy ◽  
Mite Extract ◽  
Dust Mite ◽  
House Dust Mite Extract

scholarly journals Prophylactic benefits of systemically delivered simvastatin treatment in a house dust mite challenged murine model of allergic asthma

2018 ◽  
Vol 175 (7) ◽  
pp. 1004-1016 ◽  
Author(s):  
Aruni Jha ◽  
Min H Ryu ◽  
Ojo OO ◽  
Hilary J Bews ◽  
Jules C Carlson ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Simvastatin Treatment ◽  
Dust Mite

Recombinant Lactococcus lactis NZ3900 expressing bioactive human FGF21 reduced body weight of Db/Db mice through the activity of brown adipose tissue

2020 ◽  
Vol 11 (1) ◽  
pp. 67-78 ◽  
Author(s):  
W.-Y. Cao ◽  
M. Dong ◽  
Z.-Y. Hu ◽  
J. Wu ◽  
Y.-C. Li ◽  
...  
Keyword(s):  
Body Weight ◽  
Antibiotic Resistance ◽  
Adipose Tissue ◽  
Oral Administration ◽  
Brown Adipose Tissue ◽  
Lactococcus Lactis ◽  
Metabolic Diseases ◽  
Brown Adipose ◽  
Human Fgf21

Fibroblast growth factor 21 (FGF21), a metabolism regulator, has an important effect on metabolic diseases, such as obesity and diabetes. It is also expressed in mice, and the murine source has high homology with human FGF21. Recently, it has been extensively studied and has become a potential drug target for the treatment of metabolic diseases. As it is a protein-based hormone, FGF21 cannot be easily and quickly absorbed into the blood through oral administration. Moreover, it has a 0-2 h half-life in vivo, as shown in a previous study, thus its efficacy lasts for a short period of time when used to treat metabolic diseases, limiting its clinical applications. To avoid these limitations, we used Lactococcus lactis, a food-grade bacterium, as the host to express FGF21. It could be used successfully for the expression and long-term effect of FGF21 in vivo. Instead of antibiotic resistance genes, the LacF gene was used as a selection marker in the NZ3900/PNZ8149 expression system, which is safe and could reduce the antibiotic resistance crisis. In this study, we a constructed human FGF21 expressing L. lactis strain and administered it to Db/Db mice by gavage. Compared with the control group, the body weight of mice in the experimental group was significantly reduced, and the overall homeostasis was improved in mice treated with human FGF21. Moreover, the activity of brown adipose tissue was enhanced. These results revealed that oral administration of FGF21 through heterologous expression in L. lactis appears to be an effective approach for its clinical application.

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