scholarly journals Prophylactic benefits of systemically delivered simvastatin treatment in a house dust mite challenged murine model of allergic asthma

2018 ◽  
Vol 175 (7) ◽  
pp. 1004-1016 ◽  
Author(s):  
Aruni Jha ◽  
Min H Ryu ◽  
Ojo OO ◽  
Hilary J Bews ◽  
Jules C Carlson ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Simvastatin Treatment ◽  
Dust Mite

scholarly journals Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Yao-Tung Wang ◽  
Hsu-Chung Liu ◽  
Hui-Chen Chen ◽  
Yen-Ching Lee ◽  
Tung-Chou Tsai ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Oral Immunotherapy ◽  
Mite Extract ◽  
Dust Mite ◽  
House Dust Mite Extract

scholarly journals Neutralization of TSLP Inhibits Airway Remodeling in a Murine Model of Allergic Asthma Induced by Chronic Exposure to House Dust Mite

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e51268 ◽  
Author(s):  
Zhuang-Gui Chen ◽  
Tian-Tuo Zhang ◽  
Hong-Tao Li ◽  
Fen-Hua Chen ◽  
Xiao-Ling Zou ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Chronic Exposure ◽  
Airway Remodeling ◽  
Dust Mite

Metabolomics Reveals Inflammatory-Linked Pulmonary Metabolic Alterations in a Murine Model of House Dust Mite-Induced Allergic Asthma

2014 ◽  
Vol 13 (8) ◽  
pp. 3771-3782 ◽  
Author(s):  
Wanxing Eugene Ho ◽  
Yong-Jiang Xu ◽  
Chang Cheng ◽  
Hong Yong Peh ◽  
Steven R. Tannenbaum ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Metabolic Alterations ◽  
Dust Mite

scholarly journals IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kimia Shahangian ◽  
David A. Ngan ◽  
H. H. Rachel Chen ◽  
Yeni Oh ◽  
Anthony Tam ◽  
...  
Keyword(s):  
Viral Load ◽  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Influenza Pandemic ◽  
Significant Risk ◽  
Interleukin 4 ◽  
Pandemic H1n1 ◽  
Dust Mite

Abstract Background Asthma was identified as the most common comorbidity in hospitalized patients during the 2009 H1N1 influenza pandemic. We determined using a murine model of allergic asthma whether these mice experienced increased morbidity from pandemic H1N1 (pH1N1) viral infection and whether blockade of interleukin-4 receptor α (IL-4Rα), a critical mediator of Th2 signalling, improved their outcomes. Methods Male BALB/c mice were intranasally sensitized with house dust mite antigen (Der p 1) for 2 weeks; the mice were then inoculated intranasally with a single dose of pandemic H1N1 (pH1N1). The mice were administered intraperitoneally anti-IL-4Rα through either a prophylactic or a therapeutic treatment strategy. Results Infection with pH1N1 of mice sensitized to house dust mite (HDM) led to a 24% loss in weight by day 7 of infection (versus 14% in non-sensitized mice; p < .05). This was accompanied by increased viral load in the airways and a dampened anti-viral host responses to the infection. Treatment of HDM sensitized mice with a monoclonal antibody against IL-4Rα prior to or following pH1N1 infection prevented the excess weight loss, reduced the viral load in the lungs and ameliorated airway eosinophilia and systemic inflammation related to the pH1N1 infection. Conclusion Together, these data implicate allergic asthma as a significant risk factor for H1N1-related morbidity and reveal a potential therapeutic role for IL-4Rα signalling blockade in reducing the severity of influenza infection in those with allergic airway disease.

scholarly journals Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma

Biology Open ◽  
2016 ◽  
Vol 5 (2) ◽  
pp. 112-121 ◽  
Author(s):  
Hadeesha Piyadasa ◽  
Anthony Altieri ◽  
Sujata Basu ◽  
Jacquie Schwartz ◽  
Andrew J. Halayko ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Dust Mite

IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Allergy ◽  
2021 ◽  
Author(s):  
Eva Cloots ◽  
Nincy Debeuf ◽  
Kim Deswarte ◽  
Farzaneh Fayazpour ◽  
Manon Vanheerswynghels ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Mucus Secretion ◽  
Dust Mite

scholarly journals Association between serum zonulin level and severity of house dust mite allergic asthma

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Shereen A. Baioumy ◽  
Aya Elgendy ◽  
Shereen M. Ibrahim ◽  
Sara I. Taha ◽  
Shaimaa H. Fouad
Keyword(s):  
Allergic Asthma ◽  
Intestinal Permeability ◽  
House Dust ◽  
House Dust Mite ◽  
Control Group ◽  
Asthmatic Patients ◽  
Mite Allergy ◽  
Significant Difference ◽  
Dust Mite ◽  
Barrier Defect

Abstract Background Increased intestinal permeability, either due to the exposure to antigens in asthmatic patients or due to a barrier defect, plays a critical role in susceptibility to environmental allergens. House dust mite allergy occurs more commonly than any other type of allergy among Egyptian asthmatic patients. Aim To assess the relation between serum zonulin level as a marker of increased intestinal permeability and the severity of house dust mite allergic asthma. Methods A case–control study which included 48 patients with house dust mite allergic asthma and 48 healthy control subjects attending the Allergy and Immunology Unit, Microbiology and Immunology Department, Faculty of Medicine, Zagazig University. Results A statistically significant difference was detected between the two studied groups with respect to serum IgE and serum zonulin levels (p ˂ 0.001 and ˂ 0.001, respectively). The mean serum zonulin was equal to 258.3 ± 153.01 ng/ml in the asthmatic group and 80 ± 13 ng/ml in the control group. Serum zonulin level significantly increased with the increase of asthma severity (p ˂ 0.001). The cut off value of serum zonulin was ≥ 198 ng/ml, and the area under the curve was 0.76. It displayed sensitivity equal to 80% and specificity equal to 71.4%. Its negative predictive value was equal to 83.3%. Conclusion Intestinal barrier dysfunction contributes to the pathogenesis of allergic asthma. Serum zonulin level reflects an increase in intestinal permeability. Zonulin acts as prognostic factor of severity in asthma. Correction of the gut barrier defect may have a potential positive prognostic effect in asthma.

scholarly journals SQ house dust mite sublingually administered immunotherapy tablet (ALK) improves allergic rhinitis in patients with house dust mite allergic asthma and rhinitis symptoms

2015 ◽  
Vol 114 (2) ◽  
pp. 134-140.e1 ◽  
Author(s):  
Holger Mosbech ◽  
G. Walter Canonica ◽  
Vibeke Backer ◽  
Frederic de Blay ◽  
Ludger Klimek ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Dust Mite
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