Enhancement of immune responses by co‐administration of bacterial ghosts‐mediated Neisseria gonorrhoeae DNA vaccines

2020 ◽  
Author(s):  
H. Jiao ◽  
H. Yang ◽  
W. Zheng ◽  
Q. Zhang ◽  
D. Zhao ◽  
...  
Keyword(s):  
Immune Responses ◽  
Neisseria Gonorrhoeae ◽  
Dna Vaccines ◽  
Bacterial Ghosts

scholarly journals DNA vaccines expressing conserved elements provide potent and broad immune responses

Retrovirology ◽  
2012 ◽  
Vol 9 (Suppl 2) ◽  
pp. O67
Author(s):  
GN Pavlakis ◽  
V Kulkarni ◽  
A Valentin ◽  
M Rosati ◽  
NY Sardesai ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccines

scholarly journals Evaluation of immune responses and protection induced by A2 and nucleoside hydrolase (NH) DNA vaccines against Leishmania chagasi and Leishmania amazonensis experimental infections

2007 ◽  
Vol 9 (9) ◽  
pp. 1070-1077 ◽  
Author(s):  
Francisca H.C. Zanin ◽  
Eduardo A.F. Coelho ◽  
Carlos A.P. Tavares ◽  
Eduardo A. Marques-da-Silva ◽  
Miriam Maria Silva Costa ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccines ◽  
Leishmania Amazonensis ◽  
Leishmania Chagasi ◽  
Nucleoside Hydrolase ◽  
Experimental Infections

scholarly journals Bacterial Ghosts Are an Efficient Delivery System for DNA Vaccines

2004 ◽  
Vol 172 (11) ◽  
pp. 6858-6865 ◽  
Author(s):  
Thomas Ebensen ◽  
Susanne Paukner ◽  
Claudia Link ◽  
Pavol Kudela ◽  
Carola de Domenico ◽  
...  
Keyword(s):  
Delivery System ◽  
Dna Vaccines ◽  
Efficient Delivery ◽  
Bacterial Ghosts

Mucosal immunization of BALB/c mice with DNA vaccines encoding the SEN1002 and SEN1395 open reading frames of Salmonella enterica serovar Enteritidis induces protective immunity

2015 ◽  
Vol 144 (2) ◽  
pp. 247-256 ◽  
Author(s):  
J. BELLO ◽  
D. SÁEZ ◽  
E. ESCALONA ◽  
P. VELOZO ◽  
C. A. SANTIVIAGO ◽  
...  
Keyword(s):  
Immune Responses ◽  
Protective Immunity ◽  
Dna Vaccines ◽  
Virulent Strain ◽  
Negative Control ◽  
Open Reading Frames ◽  
Secretory Iga ◽  
Salmonella Enterica Serovar Enteritidis ◽  
Humoral Immune ◽  
Limited Effectiveness

SUMMARYSalmonella Enteritidis is the main cause of foodborne salmonellosis worldwide. The limited effectiveness of current interventions against this pathogen has been the main incentive to develop new methods for the efficient control of this infection. To investigate the use of DNA vaccines against S. Enteritidis in humans, immune responses stimulated by two plasmids containing the genes designated SEN1002, located in the pathogenicity island SPI-19 and encoding a Hcp protein involved in transport mechanisms, and SEN1395, located in the genomic island ΦSE14 and encoding a protein of a new superfamily of lysozymes, were evaluated. Humoral and cellular responses following intranasal immunization of two groups of BALB/c mice with the plasmids pV1002 and pV1395 plus adjuvant were evaluated and it was observed that the IgG2a/IgG1 ratios were sixfold higher than control groups. Both plasmids stimulated specific secretory IgA production. Increased proliferation of lymphocytes and IFN-γ production were detected in both experimental groups. DNA-vaccinated mice developed protective immunity against a virulent strain of S. Enteritidis, with nearly 2 logs of protection level compared to the negative control values in the spleen. Therefore, DNA vaccines are efficient at stimulating cellular and humoral immune responses at systemic and mucosal levels.

Design and immune characterization of a novel Neisseria gonorrhoeae DNA vaccine using bacterial ghosts as vector and adjuvant

Vaccine ◽  
2018 ◽  
Vol 36 (30) ◽  
pp. 4532-4539 ◽  
Author(s):  
Hongmei Jiao ◽  
Hui Yang ◽  
Dan Zhao ◽  
Jin Chen ◽  
Qianyun Zhang ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Dna Vaccine ◽  
Bacterial Ghosts

scholarly journals Dendritic cell targeted Ccl3- and Xcl1-fusion DNA vaccines differ in induced immune responses and optimal delivery site

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Anna Lysén ◽  
Ranveig Braathen ◽  
Arnar Gudjonsson ◽  
Demo Yemane Tesfaye ◽  
Bjarne Bogen ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Immune Responses ◽  
Dna Vaccines

scholarly journals Experimental vaccine induces Th1-driven immune responses and resistance to Neisseria gonorrhoeae infection in a murine model

2017 ◽  
Vol 10 (6) ◽  
pp. 1594-1608 ◽  
Author(s):  
Y Liu ◽  
L A Hammer ◽  
W Liu ◽  
M M Hobbs ◽  
R A Zielke ◽  
...  
Keyword(s):  
Immune Responses ◽  
Neisseria Gonorrhoeae ◽  
Murine Model
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