Regnase‐1–related endoribonucleases in health and immunological diseases*

2021 ◽  
Author(s):  
Takashi Mino ◽  
Osamu Takeuchi
Keyword(s):  
Immunological Diseases

Synaptic Transmission in the Immune System

e-Neuroforum ◽  
2017 ◽  
Vol 23 (4) ◽  
Author(s):  
Jens Rettig ◽  
David R. Stevens
Keyword(s):  
Nervous System ◽  
Immune System ◽  
Synaptic Transmission ◽  
Molecular Mechanisms ◽  
Secretory Granules ◽  
Neuroendocrine Cells ◽  
Regulated Exocytosis ◽  
Protein Receptor ◽  
Immunological Synapses ◽  
Immunological Diseases

AbstractThe release of neurotransmitters at synapses belongs to the most important processes in the central nervous system. In the last decades much has been learned about the molecular mechanisms which form the basis for this fundamental process. Highly regulated exocytosis, based on the SNARE (soluble N-ethylmaleimide-sensitive attachment protein receptor) complex and its regulatory molecules is the signature specialization of the nervous system and is shared by neurons and neuroendocrine cells. Cells of the immune system use a similar mechanism to release cytotoxic materials from secretory granules at contacts with virally or bacterially infected cells or cancer cells, in order to remove these threats. These contact zones have been termed immunological synapses in reference to the highly specific targeted exocytosis of effector molecules. Recent findings indicate that mutations in SNARE or SNARE-interacting proteins are the basis of a number of devastating immunological diseases. While SNARE complexes are ubiquitous and mediate a wide variety of membrane fusion events it is surprising that in many cases the SNARE proteins involved in immunological synapses are the same molecules which mediate regulated exocytosis of transmitters and hormones in neurons and neuroendocrine cells. These similarities raise the possibility that results obtained at immunological synapses may be applicable, in particular in the area of presynaptic function, to neuronal synapses. Since immunological synapses (IS) are assembled and disassembled in about a half an hour, the use of immune cells isolated from human blood allows not only the study of the molecular mechanisms of synaptic transmission in human cells, but is particularly suited to the examination of the assembly and disassembly of these “synapses” via live imaging. In this overview we discuss areas of similarity between synapses of the nervous and immune systems and in the process will refer to results of our experiments of the last few years.

Therapeutic Approaches to Immunological Diseases

1981 ◽  
pp. 661-695 ◽  
Author(s):  
Robert A. Good ◽  
Rajendra N. Pahwa ◽  
Anne West
Keyword(s):  
Therapeutic Approaches ◽  
Immunological Diseases

The Influence of Helminths on Immunological Diseases

2014 ◽  
pp. 201-210
Author(s):  
Joel V. Weinstock ◽  
David M. Elliott
Keyword(s):  
Immunological Diseases

Novel Therapeutic Approaches and Targets for the Treatment of Cardiovascular and Immunological Diseases

2018 ◽  
Vol 19 (9) ◽  
pp. 684-685
Author(s):  
Giacomo Campi ◽  
Valentina Mercurio ◽  
Dario Fabiani ◽  
Martina Grieco ◽  
Michele Russo ◽  
...  
Keyword(s):  
Therapeutic Approaches ◽  
Immunological Diseases ◽  
Novel Therapeutic

Neonatal isoerythrolysis and other immunological diseases of foals

2011 ◽  
Vol 16 (3) ◽  
pp. 10-12
Author(s):  
Elizabeth Finding ◽  
Alex McSloy
Keyword(s):  
Immunological Diseases
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