scholarly journals E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses

2015 ◽  
Vol 266 (1) ◽  
pp. 109-122 ◽  
Author(s):  
Andrei E. Medvedev ◽  
Michael Murphy ◽  
Hao Zhou ◽  
Xiaoxia Li
Keyword(s):  
Pattern Recognition ◽  
Immune Responses ◽  
Ubiquitin Ligases ◽  
Pattern Recognition Receptor ◽  
E3 Ubiquitin Ligases ◽  
Receptor Signaling ◽  
Recognition Receptor

scholarly journals SlPRA1A/RAB attenuate EIX immune responses via degradation of LeEIX2 pattern recognition receptor

2018 ◽  
Vol 13 (5) ◽  
pp. e1467689 ◽  
Author(s):  
L. Pizarro ◽  
M. Leibman-Markus ◽  
S. Schuster ◽  
M. Bar ◽  
A. Avni
Keyword(s):  
Pattern Recognition ◽  
Immune Responses ◽  
Pattern Recognition Receptor ◽  
Recognition Receptor

scholarly journals Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152416 ◽  
Author(s):  
Takamasa Ishizuka ◽  
Paulraj Kanmani ◽  
Hisakazu Kobayashi ◽  
Ayako Miyazaki ◽  
Junichi Soma ◽  
...  
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Pattern Recognition Receptor ◽  
Receptor Signaling ◽  
Recognition Receptor

scholarly journals Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues

Oncotarget ◽  
2018 ◽  
Vol 9 (94) ◽  
pp. 36666-36683 ◽  
Author(s):  
Maria Muccioli ◽  
Harika Nandigam ◽  
Tiffany Loftus ◽  
Manindra Singh ◽  
Amritha Venkatesh ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Pattern Recognition ◽  
Cancer Cells ◽  
Pattern Recognition Receptor ◽  
Ovarian Cancer Cells ◽  
Receptor Signaling ◽  
Double Stranded Rna ◽  
Recognition Receptor

Pattern recognition receptor-mediated innate immune responses in seminal vesicle epithelial cell and their impacts on cellular function†

2019 ◽  
Vol 101 (4) ◽  
pp. 733-747 ◽  
Author(s):  
Maolei Gong ◽  
Fei Wang ◽  
Weihua Liu ◽  
Ran Chen ◽  
Han Wu ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Epithelial Cells ◽  
Immune Responses ◽  
Pattern Recognition Receptors ◽  
Seminal Vesicles ◽  
Pattern Recognition Receptor ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Toll Like Receptor ◽  
Recognition Receptor

Abstract The seminal vesicles can be infected by microorganisms, thereby resulting in vesiculitis and impairment in male fertility. Innate immune responses in seminal vesicles cells to microbial infections, which facilitate vesiculitis, have yet to be investigated. The present study aims to elucidate pattern recognition receptor–mediated innate immune responses in seminal vesicles epithelial cells. Various pattern recognition receptors, including Toll-like receptor 3, Toll-like receptor 4, cytosolic ribonucleic acid, and deoxyribonucleic acid sensors, are abundantly expressed in seminal vesicles epithelial cells. These pattern recognition receptors can recognize their respective ligands, thus activating nuclear factor kappa B and interferon regulatory factor 3. The pattern recognition receptor signaling induces expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha (Tnfa) and interleukin 6 (Il6), chemokines monocyte chemoattractant protein-1 (Mcp1) and C–X–C motif chemokine 10 (Cxcl10), and type 1 interferons Ifna and Ifnb. Moreover, pattern recognition receptor-mediated innate immune responses up-regulated the expression of microsomal prostaglandin E synthase and cyclooxygenase 2, but they down-regulated semenogelin-1 expression. These results provide novel insights into the mechanism underlying vesiculitis and its impact on the functions of the seminal vesicles.

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