scholarly journals Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes

Immunology ◽  
2020 ◽  
Vol 160 (1) ◽  
pp. 24-37 ◽  
Author(s):  
Masahiro Ono
Keyword(s):  
Transcription Factor ◽  
Cell Differentiation ◽  
T Cell ◽  
T Cell Receptor ◽  
Regulatory T Cell ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
Receptor Signalling ◽  
Transcription Factor Complexes ◽  
And Function

scholarly journals Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros

1999 ◽  
Vol 190 (8) ◽  
pp. 1039-1048 ◽  
Author(s):  
Susan Winandy ◽  
Li Wu ◽  
Jin-Hong Wang ◽  
Katia Georgopoulos
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
Tcr Signaling ◽  
Double Positive ◽  
Single Positive ◽  
T Cell Malignancies ◽  
Deficient Mice

T cell differentiation relies on pre–T cell receptor (TCR) and TCR signaling events that take place at successive steps of the pathway. Here, we show that two of these T cell differentiation checkpoints are regulated by Ikaros. In the absence of Ikaros, double negative thymocytes can differentiate to the double positive stage without expression of a pre-TCR complex. Subsequent events in T cell development mediated by TCR involving transition from the double positive to the single positive stage are also regulated by Ikaros. Nonetheless, in Ikaros-deficient thymocytes, the requirement of pre-TCR expression for expansion of immature thymocytes as they progress to the double positive stage is still maintained, and the T cell malignancies that invariably arise in the thymus of Ikaros-deficient mice are dependent on either pre-TCR or TCR signaling. We conclude that Ikaros regulates T cell differentiation, selection, and homeostasis by providing signaling thresholds for pre-TCR and TCR.

scholarly journals The transcription factor Gli3 regulates differentiation of fetal CD4–CD8– double-negative thymocytes

Blood ◽  
2005 ◽  
Vol 106 (4) ◽  
pp. 1296-1304 ◽  
Author(s):  
Ariadne L. Hager-Theodorides ◽  
Johannes T. Dessens ◽  
Susan V. Outram ◽  
Tessa Crompton
Keyword(s):  
Transcription Factor ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
Double Negative ◽  
Thymocyte Development ◽  
Tcr Signaling ◽  
Double Positive ◽  
Dose Dependent

AbstractGlioblastoma 3 (Gli3) is a transcription factor involved in patterning and oncogenesis. Here, we demonstrate a role for Gli3 in thymocyte development. Gli3 is differentially expressed in fetal CD4–CD8– double-negative (DN) thymocytes and is most highly expressed at the CD44+ CD25– DN (DN1) and CD44–CD25– (DN4) stages of development but was not detected in adult thymocytes. Analysis of null mutants showed that Gli3 is involved at the transitions from DN1 to CD44+ CD25+ DN (DN2) cell and from DN to CD4+CD8+ double-positive (DP) cell. Gli3 is required for differentiation from DN to DP thymocyte, after pre–T-cell receptor (TCR) signaling but is not necessary for pre-TCR–induced proliferation or survival. The effect of Gli3 was dose dependent, suggesting its direct involvement in the transcriptional regulation of genes controlling T-cell differentiation during fetal development.

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

Nature ◽  
1987 ◽  
Vol 327 (6124) ◽  
pp. 677-682 ◽  
Author(s):  
Yueh-hsiu Chien ◽  
Makio Iwashima ◽  
Kenneth B. Kaplan ◽  
John F. Elliott ◽  
Mark M. Davis
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Receptor ◽  
Receptor Gene ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
T Cell Receptor Gene ◽  
Cell Receptor Gene

The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions

Cell ◽  
1985 ◽  
Vol 40 (3) ◽  
pp. 591-597 ◽  
Author(s):  
Vikas P. Sukhatme ◽  
Kurt C. Sizer ◽  
Amy C. Vollmer ◽  
Tim Hunkapiller ◽  
Jane R. Parnes
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
Differentiation Antigen ◽  
Variable Regions

scholarly journals The Transcriptional Regulator Id2 Is Critical for Adipose-Resident Regulatory T Cell Differentiation, Survival, and Function

2019 ◽  
Vol 203 (3) ◽  
pp. 658-664 ◽  
Author(s):  
Adolfo B. Frias ◽  
Eric J. Hyzny ◽  
Heather M. Buechel ◽  
Lisa Y. Beppu ◽  
Bingxian Xie ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Regulatory T Cell ◽  
Transcriptional Regulator ◽  
T Cell Differentiation ◽  
And Function
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