scholarly journals T cell receptor signalling in the control of regulatory T cell differentiation and function

2016 ◽  
Vol 16 (4) ◽  
pp. 220-233 ◽  
Author(s):  
Ming O. Li ◽  
Alexander Y. Rudensky
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Receptor ◽  
Regulatory T Cell ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
Receptor Signalling ◽  
And Function

scholarly journals Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros

1999 ◽  
Vol 190 (8) ◽  
pp. 1039-1048 ◽  
Author(s):  
Susan Winandy ◽  
Li Wu ◽  
Jin-Hong Wang ◽  
Katia Georgopoulos
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
Tcr Signaling ◽  
Double Positive ◽  
Single Positive ◽  
T Cell Malignancies ◽  
Deficient Mice

T cell differentiation relies on pre–T cell receptor (TCR) and TCR signaling events that take place at successive steps of the pathway. Here, we show that two of these T cell differentiation checkpoints are regulated by Ikaros. In the absence of Ikaros, double negative thymocytes can differentiate to the double positive stage without expression of a pre-TCR complex. Subsequent events in T cell development mediated by TCR involving transition from the double positive to the single positive stage are also regulated by Ikaros. Nonetheless, in Ikaros-deficient thymocytes, the requirement of pre-TCR expression for expansion of immature thymocytes as they progress to the double positive stage is still maintained, and the T cell malignancies that invariably arise in the thymus of Ikaros-deficient mice are dependent on either pre-TCR or TCR signaling. We conclude that Ikaros regulates T cell differentiation, selection, and homeostasis by providing signaling thresholds for pre-TCR and TCR.

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

Nature ◽  
1987 ◽  
Vol 327 (6124) ◽  
pp. 677-682 ◽  
Author(s):  
Yueh-hsiu Chien ◽  
Makio Iwashima ◽  
Kenneth B. Kaplan ◽  
John F. Elliott ◽  
Mark M. Davis
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Receptor ◽  
Receptor Gene ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
T Cell Receptor Gene ◽  
Cell Receptor Gene

The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions

Cell ◽  
1985 ◽  
Vol 40 (3) ◽  
pp. 591-597 ◽  
Author(s):  
Vikas P. Sukhatme ◽  
Kurt C. Sizer ◽  
Amy C. Vollmer ◽  
Tim Hunkapiller ◽  
Jane R. Parnes
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
Differentiation Antigen ◽  
Variable Regions

scholarly journals The Transcriptional Regulator Id2 Is Critical for Adipose-Resident Regulatory T Cell Differentiation, Survival, and Function

2019 ◽  
Vol 203 (3) ◽  
pp. 658-664 ◽  
Author(s):  
Adolfo B. Frias ◽  
Eric J. Hyzny ◽  
Heather M. Buechel ◽  
Lisa Y. Beppu ◽  
Bingxian Xie ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Regulatory T Cell ◽  
Transcriptional Regulator ◽  
T Cell Differentiation ◽  
And Function

scholarly journals T cell differentiation stages identified by molecular and immunologic analysis of the T cell receptor complex in childhood lymphoblastic leukemia

Blood ◽  
1987 ◽  
Vol 69 (3) ◽  
pp. 908-912 ◽  
Author(s):  
J Jr Mirro ◽  
G Kitchingman ◽  
FG Behm ◽  
SB Murphy ◽  
RM Goorha
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Receptor ◽  
Lymphoblastic Leukemia ◽  
Cell Receptor ◽  
T Cell Differentiation ◽  
Receptor Complex ◽  
Beta Chain ◽  
Alpha Chain ◽  
Beta Chain Genes

Abstract T cell differentiation was investigated by determining the relationship of T cell receptor (Ti) gene rearrangement and transcription to the expression of surface and cytoplasmic T3 antigen using blast cells from five children with acute lymphoblastic leukemia of thymic origin. Patterns of monoclonal antibody (MoAb) reactivity indicated that these cases were representative of the three recognized stages (I, II, III) of human thymocyte development. The T3 antigen, which becomes linked to the Ti to form a functional T cell receptor complex on mature thymocytes, was expressed on the cell surface in two cases (stage III). However, in the remaining three cases that were surface T3 negative (stages I and II), large amounts of T3 were identified in the cytoplasm by immunoperoxidase staining and flow cytometry. Leukemic blasts from all five patients showed rearranged genes encoding the beta-chain portion of the Ti heterodimer. RNA transcripts of Ti beta-chain genes were also evident in lymphoblasts from all five cases, but transcripts coding for the alpha-chain portion of Ti were found only in cases that expressed T3 on the cell surface. Thus the absence of surface T3 (and presumably Ti) coincides with the absence of Ti alpha-chain RNA, suggesting that transcription of alpha-chain genes is a critical regulatory event in the surface expression of the Ti-T3 complex. Leukemic T cells that rearrange and express Ti beta-chain genes but lack Ti alpha-chain messenger RNA (mRNA) may represent a stage of differentiation analogous to pre-B cells, where heavy-chain immunoglobulin (Ig) genes are rearranged and expressed but light-chain Ig genes are not expressed.

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