Stress Ulcer Prophylaxis in Critically Ill Adult Patients with Sepsis at Risk of Gastrointestinal Bleeding: A Retrospective Cohort Study

2021 ◽  
Author(s):  
Minqiang Huang ◽  
Ming Han ◽  
Zhi Song ◽  
Lei Kuang
Keyword(s):  
At Risk ◽  
Cohort Study ◽  
Gastrointestinal Bleeding ◽  
Critically Ill ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Stress Ulcer ◽  
Stress Ulcer Prophylaxis ◽  
Adult Patients ◽  
Ulcer Prophylaxis

scholarly journals Proton pump inhibitors versus histamine-2 receptor blockers for stress ulcer prophylaxis in patients with sepsis: a retrospective cohort study

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110251
Author(s):  
Minqiang Huang ◽  
Ming Han ◽  
Wei Han ◽  
Lei Kuang
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Hospital Mortality ◽  
Critically Ill ◽  
Proton Pump ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Stress Ulcer ◽  
Increased Risk ◽  
Ulcer Prophylaxis

Objective We aimed to compare the efficacy and risks of proton pump inhibitor (PPI) versus histamine-2 receptor blocker (H2B) use for stress ulcer prophylaxis (SUP) in critically ill patients with sepsis and risk factors for gastrointestinal bleeding (GIB). Methods In this retrospective cohort study, we used the Medical Information Mart for Intensive Care III Clinical Database to identify critically ill adult patients with sepsis who had at least one risk factor for GIB and received either an H2B or PPI for ≥48 hours. Propensity score matching (PSM) was conducted to balance baseline characteristics. The primary outcome was in-hospital mortality. Results After 1:1 PSM, 1056 patients were included in the H2B and PPI groups. The PPI group had higher in-hospital mortality (23.8% vs. 17.5%), GIB (8.9% vs. 1.6%), and pneumonia (49.6% vs. 41.6%) rates than the H2B group. After adjusting for risk factors of GIB and pneumonia, PPI use was associated with a 1.28-times increased risk of in-hospital mortality, 5.89-times increased risk of GIB, and 1.32-times increased risk of pneumonia. Conclusions Among critically ill adult patients with sepsis at risk for GIB, SUP with PPIs was associated with higher in-hospital mortality and higher risk of GIB and pneumonia than H2Bs.

scholarly journals A single-centered, retrospective cohort study of critically ill COVID-19 patients: Is the heart at risk?

2020 ◽  
Vol 27 (2) ◽  
pp. 1-6
Author(s):  
Annie Loraine E. Khan ◽  
Glenn Rose B. Advincula ◽  
Francis Charles L. Fernandez ◽  
Simonette Kristine T. Sawit
Keyword(s):  
At Risk ◽  
Cohort Study ◽  
Critically Ill ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort

Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis

2003 ◽  
Vol 29 (8) ◽  
pp. 1306-1313 ◽  
Author(s):  
Christophe Faisy ◽  
Emmanuel Guerot ◽  
Jean-Luc Diehl ◽  
Eléonore Iftimovici ◽  
Jean-Yves Fagon
Keyword(s):  
Gastrointestinal Bleeding ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Stress Ulcer ◽  
Stress Ulcer Prophylaxis ◽  
Clinically Significant ◽  
Ulcer Prophylaxis

scholarly journals Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Myung Jin Song ◽  
Seok Kim ◽  
Dachung Boo ◽  
Changhyun Park ◽  
Sooyoung Yoo ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Adverse Events ◽  
Gastrointestinal Bleeding ◽  
Critically Ill ◽  
Proton Pump ◽  
Critically Ill Patients ◽  
Stress Ulcer ◽  
Stress Ulcer Prophylaxis ◽  
Ulcer Prophylaxis

AbstractProton pump inhibitors (PPIs), followed by histamine 2 receptor antagonists (H2RAs), are the most commonly used drugs to prevent gastrointestinal bleeding in critically ill patients through stress ulcer prophylaxis. The relative efficacy and drug-related adverse events of PPIs and H2RAs remain unclear. In this retrospective, observational, comparative cohort study, PPIs and H2RAs for stress ulcer prophylaxis in critically ill patients were compared using a common data model. After propensity matching, 935 patients from each treatment group (PPI or H2RA) were selected. The PPI group had a significantly higher 90-day mortality than the H2RA group (relative risk: 1.28; P = 0.01). However, no significant inter-group differences in the risk of clinically important gastrointestinal bleeding were observed. Moreover, there were no significant differences between the groups concerning the risk of pneumonia or Clostridioides difficile infection, which are known potential adverse events related to these drugs. Subgroup analysis of patients with high disease severity were consistent with those of the total propensity score-matched population. These findings do not support the current recommendations, which prefer PPIs for gastrointestinal bleeding prophylaxis in the intensive care unit.

scholarly journals Adherence to a stress ulcer prophylaxis protocol by critically ill patients: a prospective cohort study

2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Yuri de Albuquerque Pessoa dos Santos ◽  
Mauricio Staib Younes-Ibrahim ◽  
Lucas Lonardoni Crozatti ◽  
Dante Raglione ◽  
Luis Carlos Maia Cardozo Junior ◽  
...  
Keyword(s):  
Cohort Study ◽  
Critically Ill ◽  
Prospective Cohort Study ◽  
Critically Ill Patients ◽  
Prospective Cohort ◽  
Stress Ulcer ◽  
Stress Ulcer Prophylaxis ◽  
Ulcer Prophylaxis

scholarly journals Prognostic significance of infections in critically ill adult patients with acute liver injury: a retrospective cohort study

2016 ◽  
Vol 36 (8) ◽  
pp. 1143-1150 ◽  
Author(s):  
Alexander D. Zider ◽  
Radhika Zopey ◽  
Ronak Garg ◽  
Xiaoyan Wang ◽  
Tisha S. Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Injury ◽  
Critically Ill ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Acute Liver Injury ◽  
Prognostic Significance ◽  
Adult Patients
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