scholarly journals Membrane association of a model CD4 + T‐cell vaccine antigen confers enhanced yet incomplete protection against murid herpesvirus‐4 infection

2020 ◽  
Vol 98 (4) ◽  
pp. 332-343
Author(s):  
Joseph Yunis ◽  
Alec J Redwood ◽  
Gabrielle T Belz ◽  
Philip G Stevenson
Keyword(s):  
T Cell ◽  
Cd4 T Cell ◽  
Vaccine Antigen ◽  
Cell Vaccine ◽  
Membrane Association ◽  
T Cell Vaccine ◽  
Herpesvirus 4

Highly immunogenic virally vectored T cell vaccine against HCV are able to induce specific CD4+ T cell helper responses

2018 ◽  
Vol 68 ◽  
pp. S790-S791
Author(s):  
I. Esposito ◽  
F. Hartnell ◽  
L. Swadling ◽  
C. Phetsouphanh ◽  
A. Brown ◽  
...  
Keyword(s):  
T Cell ◽  
Cd4 T Cell ◽  
Cell Vaccine ◽  
T Cell Vaccine

scholarly journals Designing Peptide-Based HIV Vaccine for Chinese

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Jiayi Shu ◽  
Xiaojuan Fan ◽  
Jie Ping ◽  
Xia Jin ◽  
Pei Hao
Keyword(s):  
T Cell ◽  
Human Leukocyte ◽  
Hiv Vaccine ◽  
Cd4 T Cell ◽  
Cell Vaccine ◽  
Vaccine Research ◽  
Leukocyte Antigen ◽  
Cell Responses ◽  
T Cell Vaccine ◽  
Hla Dr

CD4+ T cells are central to the induction and maintenance of CD8+ T cell and antibody-producing B cell responses, and the latter are essential for the protection against disease in subjects with HIV infection. How to elicit HIV-specific CD4+ T cell responses in a given population using vaccines is one of the major areas of current HIV vaccine research. To design vaccine that targets specifically Chinese, we assembled a database that is comprised of sequences from 821 Chinese HIV isolates and 46 human leukocyte antigen (HLA) DR alleles identified in Chinese population. We then predicted 20 potential HIV epitopes using bioinformatics approaches. The combination of these 20 epitopes has a theoretical coverage of 98.1% of the population for both the prevalent HIV genotypes and also Chinese HLA-DR types. We suggest that testing this vaccine experimentally will facilitate the development of a CD4+ T cell vaccine especially catered for Chinese.

Can a T-Cell Vaccine Block Escape?

2013 ◽  
pp. 147-160
Author(s):  
W. David Wick ◽  
Otto O. Yang
Keyword(s):  
T Cell ◽  
Cell Vaccine ◽  
T Cell Vaccine

scholarly journals In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine

Gene Therapy ◽  
2007 ◽  
Vol 14 (20) ◽  
pp. 1481-1491
Author(s):  
S Cayeux ◽  
B Bukarica ◽  
C Buschow ◽  
J Charo ◽  
M Bunse ◽  
...  
Keyword(s):  
T Cell ◽  
Tumour Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Cell Vaccine ◽  
Systemic Immunity

Novel approaches in polyepitope T-cell vaccine development against HIV-1

2013 ◽  
Vol 13 (1) ◽  
pp. 155-173 ◽  
Author(s):  
Larisa I Karpenko ◽  
Sergei I Bazhan ◽  
Denis V Antonets ◽  
Igor M Belyakov
Keyword(s):  
T Cell ◽  
Vaccine Development ◽  
Cell Vaccine ◽  
T Cell Vaccine ◽  
Novel Approaches ◽  
Hiv 1

scholarly journals Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take?

2017 ◽  
Vol 10 (9) ◽  
pp. a028910 ◽  
Author(s):  
Lalit K. Beura ◽  
Stephen C. Jameson ◽  
David Masopust
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Vaccine ◽  
T Cell Vaccine

scholarly journals T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces

2009 ◽  
Vol 83 (17) ◽  
pp. 8300-8314 ◽  
Author(s):  
Bette T. Korber ◽  
Norman L. Letvin ◽  
Barton F. Haynes
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Cell Vaccine ◽  
T Cell Vaccine ◽  
Immunodeficiency Virus

scholarly journals Biopolymer encapsulated live influenza virus as a universal CD8+ T cell vaccine against influenza virus

Vaccine ◽  
2010 ◽  
Vol 29 (2) ◽  
pp. 314-322 ◽  
Author(s):  
Alina C. Boesteanu ◽  
Nadarajan S. Babu ◽  
Margaret Wheatley ◽  
Elisabeth S. Papazoglou ◽  
Peter D. Katsikis
Keyword(s):  
Influenza Virus ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cell Vaccine ◽  
T Cell Vaccine
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