scholarly journals The effects of human umbilical cord multipotent mesenchymal stromal cells on the behavior and oxidative stress in the brain of mice of different ages with a cuprizone-induced model of demyelination

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
I. Labunets ◽  
◽  
N. Utko ◽  
O. Toporova ◽  
T. Panteleimonova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Human Umbilical Cord ◽  
Different Ages ◽  
The Brain ◽  
And Oxidative Stress

scholarly journals Therapeutic effect of human umbilical cord-derived multipotent mesenchymal stromal cells in a patient with Crigler–Najjar syndrome type I

2019 ◽  
Vol 64 (4) ◽  
pp. 26-34
Author(s):  
G. T. Sukhikh ◽  
A. V. Degtyareva ◽  
D. N. Silachev ◽  
K. V. Gorunov ◽  
I. V. Dubrovina ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Human Umbilical Cord ◽  
Type I ◽  
Syndrome Type ◽  
Safe Level ◽  
Period 2

The article presents the results of intravenous transplantation of allogeneic multipotent mesenchymal stromal cells, derived from a human umbilical cord, to a child with Crigler–Najjarsyndrome type I during the first 2 years of life. The therapy is aimed at reduction of the duration of phototherapy while maintaining a safe level of serum bilirubin.In this study, a five-day-old child with the bilirubin level of 340 µmol/l was treated with phototherapy for 16–18 hours daily in the neonatal period. Then, phototherapy was reduced to 14–16 hours. The level of bilirubin varied from 329 to 407 μmol/l. At the age of 2 months, it was decided to use multipotent mesenchymal stromal cells with a significant decrease in the duration of phototherapy up to 2 hours a day. During the observation period (2 years at the time of writing this article) the child received 6 injections of multipotent mesenchymal stromal cells. A positive effect developed within 4–7 days after administration and persisted for 2–3 months. There were no side effects or complications during and after transplantation.Thus, intravenous transplantation of multipotent mesenchymal stromal cells is an effective treatment of Crigler–Najjar syndrome type I; it reducesthe need for phototherapy,significantly improvesthe quality of life of the patients and prolongstheir life with native liver. 

scholarly journals Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Camila Eleuterio Rodrigues ◽  
José Manuel Condor Capcha ◽  
Ana Carolina de Bragança ◽  
Talita Rojas Sanches ◽  
Priscila Queiroz Gouveia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Kidney Injury ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Kidney Injury ◽  
Human Umbilical Cord ◽  
Renal Senescence

scholarly journals The Effect of Human Umbilical Cord Mesenchymal Stromal Cells in Protection of Dopaminergic Neurons from Apoptosis by Reducing Oxidative Stress in the Early Stage of a 6-OHDA-Induced Parkinson’s Disease Model

2019 ◽  
Vol 28 (1_suppl) ◽  
pp. 87S-99S ◽  
Author(s):  
Heng Chi ◽  
Yunqian Guan ◽  
Fengyan Li ◽  
Zhiguo Chen
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Early Stage ◽  
Disease Model ◽  
Human Umbilical Cord ◽  
And Oxidative Stress ◽  
Neuron Apoptosis

Oxidative stress is an important cause of dopaminergic (DA) neuron apoptosis in Parkinson’s disease (PD). Mesenchymal stromal cells (MSCs) possess antioxidative features. In this study, we investigated whether MSCs could reduce oxidative stress and protect DA neurons from apoptosis by intravenous (I.V.) injection in the early stage of a 6-hydroxydopamine (6-OHDA)-induced PD model. MSCs were injected into the tail vein of mice, and behavioral tests, immunofluorescence staining, western blot, and oxidative stress levels were assessed at different time points. After 6-OHDA exposure, DA neuron apoptosis was detected, together with severe oxidative stress in brain and periphery. Compared with the non-transplanted sham controls, motor function in the 6-OHDA-lesioned group after I.V. injection of MSCs was significantly improved, and the levels of DA neuron apoptosis and oxidative stress decreased. The results demonstrate that MSCs can rescue DA neurons from ongoing apoptosis by reducing oxidative stress, and provide insights on developing new therapeutic strategies to offset the degenerative process of PD.

scholarly journals Parameters that influence the isolation of multipotent mesenchymal stromal cells from human umbilical cord blood

2013 ◽  
Vol 6 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Attiyeh Vasaghi ◽  
Atefeh Dehghani ◽  
Zeinab Khademalhosseini ◽  
Mohsen Khosravi Maharlooei ◽  
Ahmad Monabati ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Umbilical Cord Blood ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

Optimized Protocol for Isolation of Multipotent Mesenchymal Stromal Cells from Human Umbilical Cord

2015 ◽  
Vol 160 (1) ◽  
pp. 148-154 ◽  
Author(s):  
Yu. A. Romanov ◽  
E. E. Balashova ◽  
N. E. Volgina ◽  
N. V. Kabaeva ◽  
T. N. Dugina ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Human Umbilical Cord ◽  
Optimized Protocol

Isolation of Multipotent Mesenchymal Stromal Cells from Cryopreserved Human Umbilical Cord Tissue

2016 ◽  
Vol 160 (4) ◽  
pp. 530-534 ◽  
Author(s):  
Yu. A. Romanov ◽  
E. E. Balashova ◽  
N. E. Volgina ◽  
N. V. Kabaeva ◽  
T. N. Dugina ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Human Umbilical Cord ◽  
Umbilical Cord Tissue
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