Refining peripheral blood smear review rules for neonatal inpatients in a South African academic laboratory

2016 ◽  
Vol 38 (4) ◽  
pp. 347-351 ◽  
Author(s):  
J. Vaughan ◽  
N. Alli ◽  
K. Mannaru ◽  
Q. Sedick
Keyword(s):  
South African ◽  
Peripheral Blood ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Academic Laboratory ◽  
Blood Smear Review

scholarly journals And the Oscar goes to peripheral blood film for detection of lead poisoning in a complicated patient: A case report with review of laboratory clues

2020 ◽  
Author(s):  
Amir Zamani ◽  
Ehsan Sarraf Kazerooni ◽  
S Saeed Kasaee ◽  
Mohammad Hossein Anbardar ◽  
Sahand Mohammadzadeh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lead Poisoning ◽  
Peripheral Blood ◽  
Blood Smear ◽  
Lead Level ◽  
Peripheral Blood Smear ◽  
Blood Film ◽  
Short Period ◽  
Bone Marrow Study ◽  
Blood Smear Review

Abstract Background Peripheral blood smear examination is an invaluable laboratory test which provides the complete hematologic and/or non-hematologic picture of a case. In addition to verifying the results of automated cell counters, it has the potential to identify some pathologic morphologic changes that remain hidden using the cell counters alone. Case presentation A 40-year-old man with a 3 year history of alcohol intake and marijuana abuse presented with severe lower extremities bone pain and abdominal pain. Physical examination showed high blood pressure, high pulse rate and abdominal tenderness. He underwent extensive laboratory and imaging tests, and cholecystectomy and bone marrow study, without any definite diagnosis or improvement. Right after all these invasive, expensive and time consuming investigations during a month, finding a point on the peripheral blood smear by an expert led to the final diagnosis. The finding was coarse basophilic stippling in the red blood cells. Elevated blood lead level and the presence of ring sideroblast in the bone marrow study confirmed the diagnosis of lead poisoning and the patient responded well to chelator therapy in a short period. Conclusion This case clearly shows the value of peripheral blood smear review and its impact on the patient care. In order not to lose the cases, laboratories are recommended to design their own policy for peripheral blood smear review. Peripheral blood smear is the fastest, simplest, and most available screening test which could prevent many misdiagnoses and malpractices. It provides rich morphological information, among which basophilic stippling is highly suggestive of lead poisoning.

Sensitivity of Peripheral Blood Smear Review for the Diagnosis of Candida Fungemia

2007 ◽  
Vol 131 (1) ◽  
pp. 97-101
Author(s):  
John A. Branda ◽  
Mary Jane Ferraro ◽  
Alexander Kratz
Keyword(s):  
Peripheral Blood ◽  
Blood Smear ◽  
Case Reports ◽  
Peripheral Blood Smear ◽  
Technical Staff ◽  
Staff Members ◽  
Blood Smear Examination ◽  
Yeast Concentration ◽  
Peripheral Blood Smears ◽  
Blood Smear Review

Abstract Context.—Case reports have described detection of candidemia by examination of peripheral blood smears. It is unclear whether this method has wider applicability for early detection of fungemia. Objective.—To determine the sensitivity of smear review for detecting candidemia. Design.—Normal and cytopenic blood was spiked with increasing concentrations of yeast. Smears were prepared and reviewed by a pathologist and by technical staff. Staff members blinded to the purpose of the study first performed a routine slide review and then a targeted review for yeast. Results.—The pathologist detected isolated yeast forms at a concentration of 1 to 5 × 105 colony-forming units (CFU)/mL. When blinded to the purpose of the study, technical staff could detect Candida in most samples when the yeast concentration was 1 to 5 × 107 CFU/mL, but found it in only a small fraction of samples with lower concentrations. When asked to examine the smears specifically for yeast, they could detect it in most samples containing 1 to 5 × 106 CFU/mL. Conclusions.—Detection of candidemia by peripheral blood smear examination requires a yeast concentration of 1 to 5 × 105 CFU/mL or greater. This degree of fungemia is unusual; therefore, detection of candidemia by blood smear review will not be possible in most cases. Sensitivity of smear review for yeast detection is greatly increased if the microscopist is specifically directed to look for the presence of yeast.

scholarly journals Rapid Presumptive Diagnosis of Hantavirus Cardiopulmonary Syndrome by Peripheral Blood Smear Review

2001 ◽  
Vol 116 (5) ◽  
pp. 665-672 ◽  
Author(s):  
Frederick Koster ◽  
Kathryn Foucar ◽  
Brian Hjelle ◽  
Amy Scott ◽  
Yap-Yee Chong ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Presumptive Diagnosis ◽  
Blood Smear Review
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