Associative role of HLA-DRB1 SNP genotypes as risk factors for susceptibility and severity of rheumatoid arthritis: A North-east Indian population-based study

2017 ◽  
Vol 45 (1) ◽  
pp. 1-7 ◽  
Author(s):  
S. Das ◽  
C. Baruah ◽  
A. K. Saikia ◽  
S. Bose
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Indian Population ◽  
Population Based ◽  
Population Based Study ◽  
East Indian ◽  
North East

Autoimmune hepatitis: the role of environmental risk factors: a population-based study

2013 ◽  
Vol 7 (3) ◽  
pp. 869-875 ◽  
Author(s):  
Jing H. Ngu ◽  
Richard B. Gearry ◽  
Chris M. Frampton ◽  
Catherine A. M. Stedman
Keyword(s):  
Risk Factors ◽  
Autoimmune Hepatitis ◽  
Environmental Risk ◽  
Population Based ◽  
Environmental Risk Factors ◽  
Population Based Study

Prevalence and Relationship Between Diabetic Retinopathy and Nephropathy, and its Risk Factors in the North-East of Spain, a Population-Based Study

2010 ◽  
Vol 17 (4) ◽  
pp. 251-265 ◽  
Author(s):  
Romero-Aroca Pedro ◽  
Sagarra-Alamo Ramon ◽  
Baget-Bernaldiz Marc ◽  
Fernández-Ballart Juan ◽  
Méndez-Marin Isabel
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Population Based ◽  
Population Based Study ◽  
North East ◽  
The North

scholarly journals Occurrence and Effect of Lower Extremity Ulcer in Rheumatoid Arthritis — A Population-based Study

2014 ◽  
Vol 41 (3) ◽  
pp. 437-443 ◽  
Author(s):  
Adlene J. Jebakumar ◽  
Prabhu D. Udayakumar ◽  
Cynthia S. Crowson ◽  
Sherine E. Gabriel ◽  
Eric L. Matteson
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Lower Extremity ◽  
Cumulative Incidence ◽  
Premature Mortality ◽  
Population Based ◽  
Olmsted County ◽  
Population Based Study ◽  
Rheumatoid Nodules ◽  
American College Of Rheumatology

Objective.To assess the occurrence, risk factors, morbidity, and mortality associated with lower extremity (LE) ulcers in patients with rheumatoid arthritis (RA).Methods.Retrospective review of Olmsted County, Minnesota, USA, residents who first fulfilled the 1987 American College of Rheumatology criteria for RA in 1980–2007 with followup to death, migration, or April 2012. Only LE ulcers that developed after the diagnosis of RA were included.Results.The study included 813 patients with 9771 total person-years of followup. Of them, 125 developed LE ulcers (total of 171 episodes), corresponding to a rate of occurrence of 1.8 episodes per 100 person-years (95% CI: 1.5, 2.0 per 100 person-yrs). The cumulative incidence of first LE ulcers was 4.8% at 5 years after diagnosis of RA and increased to 26.2% by 25 years. Median time for the LE ulcer to heal was 30 days. Ten of 171 episodes (6%) led to amputation. LE ulcers in RA were associated with increased mortality (HR 2.42; 95% CI 1.71, 3.42), adjusted for age, sex, and calendar year. Risk factors for LE ulcers included age (HR 1.73 per 10-yr increase; 95% CI 1.47, 2.04), rheumatoid factor positivity (HR 1.63; 95% CI 1.05, 2.53), presence of rheumatoid nodules (HR 2.14; 95% CI 1.39, 3.31), and venous thromboembolism (HR 2.16; 95% CI 1.07, 4.36).Conclusion.LE ulcers are common among patients with RA. The cumulative incidence increased by 1% per year. A significant number require amputation. Patients with RA who have LE ulcers are at a 2-fold risk for premature mortality.

scholarly journals The Impact of Immunization and Use of Oseltamivir on Influenza-Related Hospitalizations: A Population-Based Study

2021 ◽  
Vol 12 ◽  
pp. 215013272110059
Author(s):  
Vassilis Athanassoglou ◽  
Lauren A. Wilson ◽  
Jiabin Liu ◽  
Jashvant Poeran ◽  
Haoyan Zhong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Influenza Vaccination ◽  
Logistic Regression Model ◽  
Population Based ◽  
Multivariable Logistic Regression Model ◽  
Population Based Study ◽  
Lower Odds ◽  
Flu Vaccination ◽  
The Impact

Background As the COVID-19 pandemic continues into flu season, it is critical to minimize hospitalizations to maximize capacity and preserve critical care resources. We sought to identify risk factors for influenza-related hospitalization, specifically the role of immunization and oseltamivir prescriptions. Methods Patients with influenza diagnoses were identified from the MarketScan database (2014-2018). Primary risk factors of interest were an influenza vaccination within 6 months prior to infection and oseltamivir prescriptions (filled on the day diagnosis, the following day, or 2-5 days). A multivariable logistic regression model was run to identify risk factors for influenza-related hospitalizations within 30 days of diagnosis. Results Among 2 395 498 influenza infections, 0.27% were hospitalized. Of those prescribed oseltamivir the day of diagnosis, 0.13% were later hospitalized, compared to 0.67% among those who filled prescriptions the following day and 11.8% when filled within 2 to 5 days. Upon adjustment, oseltamivir prescriptions filled on the day of diagnosis were associated with significantly decreased odds of hospitalization (OR 0.51 CI 0.48-0.55). Prescriptions filled within 1 to 5 days of diagnosis were associated with significantly increased odds of hospitalization (1 day OR 2.01 CI 1.81-2.24; 2-5 days OR 34.1 CI 31.7-36.6). Flu vaccination was associated with a lower odds for hospitalization (OR 0.84 CI 0.74-0.95). Conclusions We recommend oseltamivir be prescribed to patients when they first present with influenza-like symptoms to reduce the burden on the healthcare system. We also identified reduced odds of hospitalization associated with influenza vaccination, which is already well established, but particularly important this coming flu season.

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