The interleukin 6 receptor alpha gene polymorphisms are associated with clinical manifestations of systemic lupus erythematosus in Koreans

2013 ◽  
Vol 40 (5) ◽  
pp. 356-360 ◽  
Author(s):  
J. Y. Jeon ◽  
K. Y. Kim ◽  
H. A. Kim ◽  
C. H. Suh
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Receptor Alpha ◽  
Interleukin 6 Receptor ◽  
Alpha Gene

scholarly journals Interleukin‐6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus

2016 ◽  
Vol 25 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Peter Birner ◽  
Susanne Heider ◽  
Peter Petzelbauer ◽  
Peter Wolf ◽  
Christoph Kornauth ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Murine Model ◽  
Lupus Erythematosus ◽  
Interleukin 6 ◽  
Skin Lesions ◽  
Systemic Lupus ◽  
Receptor Alpha ◽  
Interleukin 6 Receptor ◽  
Alpha Blockade

Vitamin D receptor (VDR) gene polymorphisms and susceptibility to systemic lupus erythematosus clinical manifestations

Lupus ◽  
2013 ◽  
Vol 22 (11) ◽  
pp. 1110-1117 ◽  
Author(s):  
J de Azevêdo Silva ◽  
K Monteiro Fernandes ◽  
JA Trés Pancotto ◽  
T Sotero Fragoso ◽  
EA Donadi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Lupus Erythematosus ◽  
Gene Polymorphisms ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms

Estrogen receptor alpha gene polymorphism and systemic lupus erythematosus: a possible risk?

Lupus ◽  
2005 ◽  
Vol 14 (5) ◽  
pp. 391-398 ◽  
Author(s):  
E Kassi ◽  
P G Vlachoyiannopoulos ◽  
A Kominakis ◽  
H Kiaris ◽  
H M Moutsopoulos ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Estrogen Receptor ◽  
Gene Polymorphism ◽  
Lupus Erythematosus ◽  
Estrogen Receptor Alpha ◽  
Systemic Lupus ◽  
Receptor Alpha ◽  
Estrogen Receptor Alpha Gene ◽  
Alpha Gene

scholarly journals Correlation between serum interleukin-6 with glomerular filtration rate in systemic lupus erythematosus

2019 ◽  
Vol 3 (1) ◽  
pp. 22-25
Author(s):  
Gede Kambayana ◽  
Meryl Pulcheria ◽  
I Gde Raka Widiana
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Lupus Erythematosus ◽  
Interleukin 6 ◽  
Filtration Rate ◽  
Pearson Correlation ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Pearson Correlation Test

Background: Systemic lupus erythematosus (SLE) is characterized by remarkable heterogeneity in clinical manifestations with underlying autoimmune mechanisms. The pleiotropic cytokine interleukin-6 (IL-6) is known to be involved in SLE immunopathogenesis and significantly related to disease activity as well as its complications. Additionally, IL-6 has been demonstrated to underlie important roles in lupus nephritis. Objective: To determine the correlation between Interleukin 6 (IL-6) Serum and Glomelular Filtration Rate (GFR) in SLE. Methods: In this study we investigated the correlation of serum IL-6 with glomerular filtration rate (GFR) to assess kidney damage in 67 premenopausal patients aged between 17-50 years with inactive SLE. The study variables including age, duration of illness, cumulative corticosteroid dose, MEX-SLEDAI score, serum creatinine, and GFR were obtained through interview and medical record review; whilst serum level of IL-6 was measured using ELISA. Results: Median level of IL-6 was found to be 2.71 (0.332-10.000) pg/ml. Pearson correlation test showed significant correlation between serum IL-6 and GFR (r = 0.288, P = 0.018). Conclusion: This study result shows that there was positive correlation observed between serum IL-6 and GFR in inactive SLE.

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