scholarly journals Angiotensin‐converting enzyme inhibitory activity of hydrolysates generated from whey protein fortified with salal fruits ( Galtheria shallon ) by enzymatic treatment with Pronase from Streptomyces griseus

2019 ◽  
Vol 54 (11) ◽  
pp. 2975-2982 ◽  
Author(s):  
Vassilios Raikos ◽  
Helen Hays ◽  
David Stead ◽  
He Ni
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Whey Protein ◽  
Inhibitory Activity ◽  
Streptomyces Griseus ◽  
Enzymatic Treatment ◽  
Converting Enzyme

Use of Different Proteases to Obtain Whey Protein Concentrate Hydrolysates with Inhibitory Activity toward Angiotensin-Converting Enzyme

2013 ◽  
Vol 38 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Harriman A. Morais ◽  
Marialice P.C. Silvestre ◽  
Larissa L. Amorin ◽  
Viviane D.M. Silva ◽  
Mauro R. Silva ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Whey Protein ◽  
Inhibitory Activity ◽  
Whey Protein Concentrate ◽  
Protein Concentrate ◽  
Converting Enzyme

Production of whey protein hydrolysates with angiotensin-converting enzyme-inhibitory activity using three new sources of plant proteases

2020 ◽  
Vol 28 ◽  
pp. 101724
Author(s):  
Miguel A. Mazorra-Manzano ◽  
Wendy G. Mora-Cortes ◽  
María M. Leandro-Roldan ◽  
Daniel A. González-Velázquez ◽  
María J. Torres-Llanez ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Whey Protein ◽  
Inhibitory Activity ◽  
Protein Hydrolysates ◽  
Converting Enzyme ◽  
Whey Protein Hydrolysates ◽  
Plant Proteases

Screening of Strains with fibrinolytic activity and angiotensin-converting enzyme inhibitory activity from doenjang

2012 ◽  
Vol 21 (2) ◽  
pp. 581-585 ◽  
Author(s):  
Tae-Woon Kim ◽  
Young-Hoon Kim ◽  
Hyun-Ji Jung ◽  
Cheon-Seok Park ◽  
Hae-Yeong Kim
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Inhibitory Activity ◽  
Fibrinolytic Activity ◽  
Converting Enzyme

scholarly journals Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside

2014 ◽  
Vol 11 ◽  
pp. 557-562 ◽  
Author(s):  
Arunee Simaratanamongkol ◽  
Kaoru Umehara ◽  
Hiroki Niki ◽  
Hiroshi Noguchi ◽  
Pharkphoom Panichayupakaranant
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Inhibitory Activity ◽  
Methyl Salicylate ◽  
Converting Enzyme ◽  
Ace Inhibitory Activity ◽  
Solanum Torvum ◽  
Ace Inhibitory

scholarly journals ANGIOTENSIN CONVERTING ENZYME INHIBITORY ACTIVITY OF MELINJO (GNETUM GNEMON L.) SEED EXTRACTS AND MOLECULAR DOCKING OF ITS STILBENE CONSTITUENTS

2017 ◽  
Vol 10 (3) ◽  
pp. 243
Author(s):  
Abdul Mun'im ◽  
Muhammad Ashar Munadhil ◽  
Nuraini Puspitasari ◽  
Azminah . ◽  
Arry Yanuar
Keyword(s):  
Molecular Docking ◽  
Angiotensin Converting Enzyme ◽  
Ethyl Acetate ◽  
Inhibitory Activity ◽  
Phenolic Content ◽  
Ethyl Acetate Extract ◽  
Total Phenolic ◽  
Converting Enzyme ◽  
Gnetum Gnemon ◽  
Ace Inhibitory

ABSTRACTObjectives: To evaluate the angiotensin converting enzyme (ACE) inhibitory activity of melinjo (Gnetum gnemon) seed extract and to study moleculardocking of stilbene contained in melinjo seeds.Methods: Melinjo seed powders were extracted with n-hexane, dichloromethane, ethyl acetate, methanol, and water successively. The extracts wereevaluated ACE inhibitory activities using ACE kit-Wist and the phenolic content using Folin–Ciocalteu method. The extract demonstrated the highestACE inhibitory activity was subjected to liquid chromatography-mass spectrometry (LC-MS) to know its stilbene constituent. The stilbene constituentsin melinjo seed were performed molecular docking using AutoDock Vina, and ligand-receptor Interactions were processed using Ligand Scout.Results: The ethyl acetate extract demonstrated the highest ACE inhibition activity with inhibitory concentration 50% value of 9.77 × 10−8 μg/mLand the highest total phenolic content (575.9 mg gallic acid equivalent/g). Ultra-performance LC-MS analysis of ethyl acetate extract has detected theexistency of resveratrol, gnetin C, ε-viniferin, and gnemonoside A/B. These compounds displayed similar physiochemical properties to lisinopril (ACEinhibitor), as in silico molecular docking studies demonstrated that they fit into the lisinopril receptors.Conclusion: In vitro analysis ethyl acetate extract from melinjo seeds demonstrated the highest ACE inhibitory activity. Molecular docking analysisindicated that resveratrol dimers, gnetin C and gnemonoside A can be considered ACE inhibitor.Keywords: Angiotensin converting enzyme inhibitor, Gnetum gnemon, Melinjo, Total phenolic, Antihypertension, Molecular docking.

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