In vitro release and antioxidant activity of Satsuma mandarin (Citrus reticulata Blanco cv. unshiu) peel flavonoids encapsulated by pectin nanoparticles

2017 ◽  
Vol 52 (11) ◽  
pp. 2362-2373 ◽  
Author(s):  
Yan Hu ◽  
Wenlin Zhang ◽  
Zunli Ke ◽  
Yan Li ◽  
Zhiqin Zhou
Keyword(s):  
Antioxidant Activity ◽  
In Vitro Release ◽  
Citrus Reticulata ◽  
Satsuma Mandarin ◽  
Citrus Reticulata Blanco ◽  
Vitro Release

Fabrication of curcumin-loaded whey protein microgels: Structural properties, antioxidant activity, and in vitro release behavior

LWT ◽  
2019 ◽  
Vol 103 ◽  
pp. 94-100 ◽  
Author(s):  
Mehdi Mohammadian ◽  
Maryam Salami ◽  
Shima Momen ◽  
Farhad Alavi ◽  
Zahra Emam-Djomeh
Keyword(s):  
Antioxidant Activity ◽  
Whey Protein ◽  
Structural Properties ◽  
In Vitro Release ◽  
Release Behavior ◽  
Vitro Release

scholarly journals Evaluation of physicochemical and antioxidant properties of nanosized copolymeric micelles loaded with kaempferol

Pharmacia ◽  
2020 ◽  
Vol 67 (2) ◽  
pp. 49-54
Author(s):  
Krassimira Yoncheva ◽  
Nadia Hristova-Avakumova ◽  
Vera Hadjimitova ◽  
Trayko Traykov ◽  
Petar Petrov
Keyword(s):  
Antioxidant Activity ◽  
Propylene Oxide ◽  
Encapsulation Efficiency ◽  
Antioxidant Properties ◽  
In Vitro Release ◽  
Before And After ◽  
Poly Propylene ◽  
Vitro Release

The study was focused on the evaluation of two copolymers as micellar carriers for kaempferol delivery. The copolymers comprised identical hydrophilic blocks of poly(2-(dimethylamino)ethyl methacrylate and different hydrophobic blocks of either poly(ε-caprolactone) (PDMAEMA9-b-PCL70-b-PDMAEMA9) or poly(propylene oxide) (PDMAEMA13-b-PPO69-b-PDMAEMA13). The calculation of Flory-Huggins parameters and determination of encapsulation efficiency showed that PDMAEMA-b-PCL-b-PDMAEMA copolymer possessed higher capacity for kaempferol loading. The diameter of the micelles before and after lyophilization was not changed, suggesting that the micelles could be lyophilized and redispersed before administration. The in vitro release of kaempferol from PDMAEMA-b-PPO-b-PDMAEMA micelles was faster than the release from PDMAEMA-b-PCL-b-PDMAEMA micelles, probably due to the higher affinity of kaempferol to this copolymer. Further, the higher affinity resulted in a retention of antioxidant activity of kaempferol in the presence of DPPH and KO2 radicals. Thus, PDMAEMA-PCL-PDMAEMA was considered more appropriate carrier because of the higher encapsulation efficiency and preservation of antioxidant activity of the drug.

scholarly journals Preparation, characterization, and evaluation of antioxidant activity and bioavailability of a self-nanoemulsifying drug delivery system (SNEDDS) for buckwheat flavonoids

2020 ◽  
Vol 52 (11) ◽  
pp. 1265-1274
Author(s):  
Zhijuan Zhao ◽  
Xiaodong Cui ◽  
Xiaoli Ma ◽  
Zhuanhua Wang
Keyword(s):  
Drug Delivery ◽  
Antioxidant Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
In Vitro Release ◽  
Scavenging Activity ◽  
Vitro Release

Abstract The self-nanoemulsifying drug delivery system has shown many advantages in drug delivery. In this study, a self-nanoemulsifying drug delivery system of buckwheat flavonoids was prepared for enhancing its antioxidant activity and oral bioavailability. A nanoemulsion of buckwheat flavonoids was developed and characterized, and its antioxidant, in vitro release, and in vivo bioavailability were determined. The nanoemulsion was optimized by the central composite design response surface experiment, and its particle size, polymer dispersity index (PDI), zeta potential, morphology, encapsulation efficiency, and stability were evaluated. The antioxidant activity was tested by measuring its 2,2-diphenyl-1-picrylhydrazyl scavenging activity, hydroxyl radical scavenging activity, and superoxide anion scavenging ability. In vitro release of buckwheat flavonoids nanoemulsion showed a higher cumulative release than the suspension, and the release fitting model followed the Ritger–Peppas and Weibull models. The effective concentration of the nanoemulsion was evaluated in vivo using a Wistar rat model, and the area under the plasma concentration-time curve of the buckwheat flavonoids nanoemulsion was 2.2-fold higher than that of the buckwheat flavonoid suspension. The Cmax of the nanoemulsion was 2.6-fold greater than that of the suspension. These results indicate that the nanoemulsion is a promising oral drug delivery system that can improve the oral bioavailability to satisfy the clinical requirements.

Thyme essential oil loaded in nanocochleates: Encapsulation efficiency, in vitro release study and antioxidant activity

LWT ◽  
2017 ◽  
Vol 77 ◽  
pp. 497-502 ◽  
Author(s):  
Martina Asprea ◽  
Isabella Leto ◽  
Maria Camilla Bergonzi ◽  
Anna Rita Bilia
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Encapsulation Efficiency ◽  
In Vitro Release ◽  
Thyme Essential Oil ◽  
Release Study ◽  
Vitro Release

Study on in vitro release patterns of fentanyl-loaded PLGA microspheres

2003 ◽  
Vol 20 (5) ◽  
pp. 569-579 ◽  
Author(s):  
S.-A. Seo ◽  
G. Khang ◽  
J. M. Rhee ◽  
J. Kim ◽  
H. B. Lee
Keyword(s):  
In Vitro Release ◽  
Plga Microspheres ◽  
Vitro Release
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