scholarly journals Preparation of blueberry anthocyanin liposomes and changes of vesicle properties, physicochemical properties, in vitro release, and antioxidant activity before and after chitosan modification

2021 ◽  
Author(s):  
Lei Wang ◽  
Lulu Wang ◽  
Xi Wang ◽  
Baojun Lu ◽  
Jing Zhang
Keyword(s):  
Antioxidant Activity ◽  
Physicochemical Properties ◽  
In Vitro Release ◽  
Before And After ◽  
Vitro Release

scholarly journals Evaluation of physicochemical and antioxidant properties of nanosized copolymeric micelles loaded with kaempferol

Pharmacia ◽  
2020 ◽  
Vol 67 (2) ◽  
pp. 49-54
Author(s):  
Krassimira Yoncheva ◽  
Nadia Hristova-Avakumova ◽  
Vera Hadjimitova ◽  
Trayko Traykov ◽  
Petar Petrov
Keyword(s):  
Antioxidant Activity ◽  
Propylene Oxide ◽  
Encapsulation Efficiency ◽  
Antioxidant Properties ◽  
In Vitro Release ◽  
Before And After ◽  
Poly Propylene ◽  
Vitro Release

The study was focused on the evaluation of two copolymers as micellar carriers for kaempferol delivery. The copolymers comprised identical hydrophilic blocks of poly(2-(dimethylamino)ethyl methacrylate and different hydrophobic blocks of either poly(ε-caprolactone) (PDMAEMA9-b-PCL70-b-PDMAEMA9) or poly(propylene oxide) (PDMAEMA13-b-PPO69-b-PDMAEMA13). The calculation of Flory-Huggins parameters and determination of encapsulation efficiency showed that PDMAEMA-b-PCL-b-PDMAEMA copolymer possessed higher capacity for kaempferol loading. The diameter of the micelles before and after lyophilization was not changed, suggesting that the micelles could be lyophilized and redispersed before administration. The in vitro release of kaempferol from PDMAEMA-b-PPO-b-PDMAEMA micelles was faster than the release from PDMAEMA-b-PCL-b-PDMAEMA micelles, probably due to the higher affinity of kaempferol to this copolymer. Further, the higher affinity resulted in a retention of antioxidant activity of kaempferol in the presence of DPPH and KO2 radicals. Thus, PDMAEMA-PCL-PDMAEMA was considered more appropriate carrier because of the higher encapsulation efficiency and preservation of antioxidant activity of the drug.

Physicochemical properties and in-vitro release study of CFLE-chitosan microsphere beads

2019 ◽  
Vol 26 (12) ◽  
Author(s):  
Vandana Suryavanshi ◽  
Preeti K. Suresh ◽  
Chayan Das ◽  
Tungabidya Maharana
Keyword(s):  
Physicochemical Properties ◽  
In Vitro Release ◽  
Chitosan Microsphere ◽  
Release Study ◽  
Vitro Release

Structural comparison, physicochemical properties, and in vitro release profile of curcumin-loaded lyotropic liquid crystalline nanoparticle: Influence of hydrotrope as interface stabilizers

2020 ◽  
Vol 306 ◽  
pp. 112861 ◽  
Author(s):  
Juliana Ferreira de Souza ◽  
Katiusca da Silva Pontes ◽  
Thais Francine Ribeiro Alves ◽  
Cecilia Torqueti de Barros ◽  
Venancio Alves Amaral ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Liquid Crystalline ◽  
In Vitro Release ◽  
Release Profile ◽  
Structural Comparison ◽  
Vitro Release

Fabrication of curcumin-loaded whey protein microgels: Structural properties, antioxidant activity, and in vitro release behavior

LWT ◽  
2019 ◽  
Vol 103 ◽  
pp. 94-100 ◽  
Author(s):  
Mehdi Mohammadian ◽  
Maryam Salami ◽  
Shima Momen ◽  
Farhad Alavi ◽  
Zahra Emam-Djomeh
Keyword(s):  
Antioxidant Activity ◽  
Whey Protein ◽  
Structural Properties ◽  
In Vitro Release ◽  
Release Behavior ◽  
Vitro Release

scholarly journals Physicochemical properties, in vitro release and in vivo evaluation of tramadol hydrochloride rectal suppository and rectal gel

2011 ◽  
Vol 5 (2) ◽  
pp. 269-275 ◽  
Author(s):  
Wantana Reanmongkol ◽  
Nattha Kaewnopparat ◽  
Chaveewan Ratanajamit
Keyword(s):  
Polyethylene Glycol ◽  
Physicochemical Properties ◽  
Analgesic Effect ◽  
In Vitro Release ◽  
Tramadol Hydrochloride ◽  
Suppository Base ◽  
Rectal Suppository ◽  
Vitro Release

Abstract Background: Tramadol is a centrally acting analgesic drug. Rectal administration of tramadol is useful in the treatment of post-operative pain or malignant pain in cases where it cannot be administered orally. In Thailand, tramadol is available only as a capsule for oral use and as a solution for injection. Objective: Develop tramadol hydrochloride rectal suppositories and rectal gel preparations. Methods: Tramadol rectal suppository and rectal gel were prepared. Physicochemical properties (viscosity, gel strength, mucoadhesive force) and the in vitro release of tramadol hydrochloride were investigated from different bases (Witepsol H15, polyethylene glycol, poloxamer, and hydroxyethylcellulose). The analgesic activity of rectal tramadol hydrochloride using the hot plate test was evaluated in rats. Results: Tramadol hydrochloride rectal gel using poloxamer was more mucoadhesive to the rectal mucous membrane than was the gel with the hydroxyethylcellulose base. Tramadol hydrochloride was released rapidly in vitro from both the Witepsol H15 and polyethylene glycol bases. It was completely released from the polyethylene glycol suppository base within 15 minutes. The amount of tramadol hydrochloride release from the Witepsol H15 suppository base was about 93% at 120 minutes. When using poloxamer or hydroxyethylcellulose as a rectal base, tramadol hydrochloride was released from both bases rapidly and completely released within 15 minutes. Administration of a tramadol hydrochloride suppository in rats exhibited a more pronounced analgesic effect with the polyethylene glycol base than with the Witepsol H15-based suppositories. The rectal gel had a less pronounced analgesic effect when made with the hydroxyethylcellulose base than with the poloxamer base. Conclusion: Tramadol hydrochloride suppositories and rectal gels with different bases showed rapid and almost complete drug release from the bases, prolonging the latency of a nociceptive response in in vivo experiments.

Investigation on the In Vitro Degradation and Release Behaviors of Calcium Phosphate Containing Chinese Medicine

2005 ◽  
Vol 284-286 ◽  
pp. 395-398 ◽  
Author(s):  
X.H. Yu ◽  
Shao Xing Qu ◽  
Y.R. Liu ◽  
R. Shen ◽  
Xiao Hong Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Calcium Phosphate ◽  
Salvia Miltiorrhiza ◽  
In Vitro Release ◽  
In Vitro Degradation ◽  
Vis Spectroscopy ◽  
Controllable Release ◽  
Before And After ◽  
Vitro Release

The purpose of this study was to investigate the in vitro degradation and release behaviors of calcium phosphate powders (Ca/P) containing Chinese Medicine for bone graft. Two kinds of Ca/P powders, one with the Chinese Medicine, Salvia Miltiorrhiza Bunge (SMB) and the other with Polyacrylic Acid (PAA) and SMB, were soaked in simulated body fluid (SBF) for up to 150h. The in vitro release of SMB was measured by UV-VIS spectroscopy. The Ca2+ concentrations and pH of SBF soaked Ca/P powders were measured by AAS and pH meter. TA and XRD were employed to analyze various Ca/P powders before and after soaked in SBF, respectively. The results demonstrated that a faster SMB release occurred during the first 24 hours, while a slow release was sustained up to150h. Furthermore, the released of SMB in Ca/P-PAA-SMB was faster than that of Ca/P-SMB. It was concluded that a controllable release of Chinese Medicine from Calcium phosphate may be carried out by the addition of suitable surfactant. Accordingly, calcium ions were released into SBF, which was benefit for bone tissue repairing and reconstructing. Additionally, the TA results showed that there was 1.66% SMB released from Ca/P-SMB-PAA powders. XRD confirmed that various Ca/P powders possessed poorer crystallinity and smaller grain size.

Optimization of PLGA nanoparticles for delivery of Novel anticancer CK-10 peptide

2021 ◽  
pp. 5371-5379
Author(s):  
Girgis Samuel ◽  
Uddin Nazim ◽  
Ahmed S.G. Srag El-Din
Keyword(s):  
Physicochemical Properties ◽  
Water Absorption ◽  
In Vitro Release ◽  
Plga Nanoparticles ◽  
Tumour Tissue ◽  
The Novel ◽  
Loading Efficiency ◽  
Electron Microscopes ◽  
Vitro Release

The main objective of this project was to formulate novel amphiphilic PLGA nanoparticles having better physicochemical properties for the delivery of the novel peptide (CK-10) to be used for targeting the cancerous/tumour tissue. Double emulsion/Solvent evaporation and novel microfluidic techniques were used to formulate the nanoparticles. Loading efficiency and in-vitro release were measured by a modified Lowry assay. Size and zeta potential were characterized by dynamic light scattering, tuneable pore resistive sensing, and laser obscuration time. Images were scanned by scanning, transmission electron microscopes, and laser obscuration time. Stability was checked by high-performance liquid chromatography and capillary zone electrophoresis. Water absorption and its associated changes in the physicochemical properties were measured by various titration techniques. PLGA/Poloxomer nanoparticles had the highest peptide loading efficiency by 56.13 % for the novel microfluidic technique as well as the highest in-vitro release and water absorption values. It also had the smallest size with the lowest PDI (208.90 nm, 0.11) which are vital parameters for targeting cancer/tumour tissue. The successful development of better physicochemical properties for the CK-10 loaded PLGA nanoparticles could improve the RAN blocking by CK-10.

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