The role of interleukin‐17 (IL‐17) in the pathogenesis of discoid lupus erythematosus and lichen planopilaris: is immunohistochemistry for IL‐17 a promising way to differentiate these entities?

2021 ◽  
Author(s):  
Mohammad Shahidi Dadras ◽  
Azadeh Rakhshan ◽  
Sahar Dadkhahfar ◽  
Tara Barat
Keyword(s):  
Lupus Erythematosus ◽  
Discoid Lupus Erythematosus ◽  
Interleukin 17 ◽  
Lichen Planopilaris

scholarly journals Focal alopecia in parietal area in adult women — assessment of usefulness of trichoscopy in making a proper diagnosis

2020 ◽  
Vol 3 (2) ◽  
pp. 86-96
Author(s):  
Dominik Mikiel ◽  
Adriana Polańska ◽  
Aleksandra Dańczak‑Pazdrowska ◽  
Ryszard Żaba ◽  
Zygmunt Adamski
Keyword(s):  
Hair Loss ◽  
Lupus Erythematosus ◽  
Diagnostic Method ◽  
Skin Surface ◽  
Control Group ◽  
Discoid Lupus Erythematosus ◽  
Adult Women ◽  
Lichen Planopilaris ◽  
Non Invasive ◽  
Parietal Area

Introduction. Focal alopecia in the parietal area is one of the types of hair loss that can be found in dermatological practice. Trichoscopy is a non-invasive and easily accessible diagnostic method widely used in scalp disorders.Aim. The aim of this study was to assess the usefulness of trichoscopy in the non-invasive diagnosis of focal hair loss in adult women.Material and Methods. The study included 40 adult women. The study group consisted of 30 patients including 10 patients with alopecia areata (AA), 10 patients with discoid lupus erythematosus (DLE) and 10 with classical form of lichen planopilaris (LPP). The control group consisted of 10 healthy volunteers. Four groups of structures observed in trichoscopic examination were evaluated: hair follicle openings, hair shafts, vessels, perifollicular and interfollicular skin surface. Results. Among patients with AA the most frequently observed trichoscopic structures were: yellow dots in 100% (10/10), broken hairs in 90% (9/10), hairs resembling exclamation marks in 90% (9/10). DLE patients most often presented white / white-pink structureless areas and prominent, interfollicular scaling in 100% (10/10) and 90% (9/10) of cases, respectively. On the other hand, in the group of patients with LPP, the most frequent findings were: fine perifollicular scaling in 100% (10/10) and linear, slightly branched vessels arranged concentrically around the follicular openings - both features observed also in 100% (10/10) of cases.Conclusion. Trichoscopy as a non-invasive diagnostic method may be helpful in differentiating non-scarring and scarring alopecia in the parietal area in women. Moreover, there are some trichoscopic features typical for AA, DLE and LPP, which allow for differentiation and facilitate the diagnosis of these entities.

scholarly journals Trichoscopy in common scalp alopecia: an observational study

2020 ◽  
Vol 6 (3) ◽  
pp. 361
Author(s):  
Krishnendra Varma ◽  
Ujjwal Singh ◽  
Manu Kataria
Keyword(s):  
Observational Study ◽  
Lupus Erythematosus ◽  
Seborrheic Dermatitis ◽  
Daily Practice ◽  
Common Finding ◽  
Discoid Lupus Erythematosus ◽  
Diagnostic Dilemma ◽  
Lichen Planopilaris ◽  
Medical College ◽  
One Year

<p class="abstract"><strong>Background:</strong> Many patients of alopecia are encountered in daily practice with diagnostic dilemma. Trichoscopy is a sensitive, non-invasive tool which aids in clinical diagnosis.</p><p class="abstract"><strong>Methods:</strong> An observational study performed in adult patients with alopecia attending R.D. Gardi Medical College, Ujjain, over a period of one year. Trichoscopy was performed using a Dinolite digital microscope with both polarized and non polarized modes.<strong></strong></p><p class="abstract"><strong>Results:</strong> 269 patients of alopecia (257 non cicatricial, 12 cicatricial) aged 18-50 years were enrolled. The diagnosis was made after detailed history and clinical examination. 173 (64.3%) males and 96 (35.7%) females. 45.4% patients were diagnosed to have alopecia areata in which yellow dots were the most common trichoscopic finding observed in 88.5% patients. 37.2% patients were diagnosed with androgenetic alopecia with hair diameter diversity &gt;20% observed in all the patients. 9.3% patients were diagnosed to have telogen effluvium with short vellus hair seen in 64% patients. 3.7% of the patients were diagnosed to have seborrheic dermatitis with arborizing vessels being the most common finding seen in 90% patients. 2.9% patients were diagnosed with lichen planopilaris in which loss of follicles and peritubular white casts were seen in all the cases. 0.9% patients were diagnosed to have discoid lupus erythematosus with hyperkeratotic follicular plugging seen in all the cases. Overall yellow dots were the most common trichoscopic findings seen in 61% cases.</p><p class="abstract"><strong>Conclusions:</strong> Trichoscopy is a reliable diagnostic tool in hair and scalp disorders. Hence trichoscopic evaluation should be done in every case of alopecia.  </p><p class="abstract"> </p>

scholarly journals Blocking IL-17: A Promising Strategy in the Treatment of Systemic Rheumatic Diseases

2020 ◽  
Vol 21 (19) ◽  
pp. 7100
Author(s):  
Carlos Rafael-Vidal ◽  
Nair Pérez ◽  
Irene Altabás ◽  
Samuel Garcia ◽  
Jose M. Pego-Reigosa
Keyword(s):  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Therapeutic Option ◽  
Premature Mortality ◽  
Interleukin 17 ◽  
Multiple Organs ◽  
Systemic Rheumatic Diseases ◽  
Bacteria And Fungi ◽  
Potential Use

Systemic rheumatic diseases are a heterogeneous group of autoimmune disorders that affect the connective tissue, characterized by the involvement of multiple organs, leading to disability, organ failure and premature mortality. Despite the advances in recent years, the therapeutic options for these diseases are still limited and some patients do not respond to the current treatments. Interleukin-17 (IL-17) is a cytokine essential in the defense against extracellular bacteria and fungi. Disruption of IL-17 homeostasis has been associated with the development and progression of rheumatic diseases, and the approval of different biological therapies targeting IL-17 for the treatment of psoriatic arthritis (PsA) and ankylosing spondylitis (AS) has highlighted the key role of this cytokine. IL-17 has been also implicated in the pathogenesis of systemic rheumatic diseases, including systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS) and systemic sclerosis (SSc). The aim of this review is to summarize and discuss the most recent findings about the pathogenic role of IL-17 in systemic rheumatic and its potential use as a therapeutic option.

ROLE OF DERMATOSCOPY IN CHRONIC DERMATOSES DIAGNOSIS

2020 ◽  
pp. 53-56
Author(s):  
G. S. Chekhovska
Keyword(s):  
Differential Diagnosis ◽  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Seborrheic Dermatitis ◽  
Hair Follicles ◽  
Discoid Lupus Erythematosus ◽  
Non Invasive ◽  
Invasive Method ◽  
Vascular Structures

Dermatoscopy is a valuable auxiliary non−invasive method used in the diagnosis of inflammatory, parasitic and viral skin diseases. Treatment of dermatoses is based on the results of analysis of melanin, follicular−horny and vascular components. Diagnosis begins with polarized dermatoscopy and then progresses to non−polarized using immersion fluid. At dermatoscopic inspection of a psoriatic plaque the point vessels evenly distributed along all the surface (a symptom of "scattered red pepper") are noted. Eczema is characterized by focal accumulation of blood vessels in the form of dots, peeling, yellowish crusts. Examination of discoid lupus erythematosus foci often reveals individual linear or branched vessels, their location is random. Red herpes zoster is dermatoscopically characterized by vascular structures in the form of large granular horny plugs of whitish color with a pearly sheen. The most informative is dermatoscopy in the differential diagnosis of erythematous form of rosacea and seborrheic dermatitis. On the erythematous background, dilated vessels around the sebaceous hair follicles, large vascular polygons formed from vessels thicker than in healthy skin and seborrheic dermatitis are found. At inspection of the fresh centers of a sclero−atrophic lichen diffuse unstructured zones of white color with a peripheral erythematous corolla and with numerous light comedic structures on a surface are visualized. At dermatoscopy of the Little − Lassueur syndrome in follicular papules on skin gray, violet points located in the form of a circle are noted. Dermatoscopy is increasingly used in dermatology, especially in the differential diagnosis of dermatoses of inflammatory and parasitic nature.

scholarly journals Pseudopelade of Brocq: a clinico-therapeutic challenge!

2014 ◽  
Vol 11 (3) ◽  
pp. 273-275
Author(s):  
S Jain
Keyword(s):  
Lupus Erythematosus ◽  
Scalp Hair ◽  
Young Male ◽  
Clinical Syndrome ◽  
Definitive Diagnosis ◽  
Discoid Lupus Erythematosus ◽  
Pathological Features ◽  
Therapeutic Challenge ◽  
Lichen Planopilaris ◽  
Specific Disease

Pseudopelade of Brocq is a clinical syndrome comprising of scarring alopecia and fibrosis in which distinct pathological features are absent. It is not a specific disease, rather a pattern of cicatricial alopecia. However, if a definitive diagnosis of DLE (discoid lupus erythematosus), LPP (Lichen planopilaris) or any other condition can be made on the basis of clinical, histopathological or immunofluorescent features, then this term cannot be used. Here we report the case of a 20 year old young male who presented to us with complaints of loss of scalp hair for 2 years which were associated with mild itching. The condition is as such rare in prevalence and hence we report the same in view of its unique presentation. DOI: http://dx.doi.org/10.3126/hren.v11i3.9652 Health Renaissance 2013;11(3):273-275

scholarly journals Lichen planopilaris versus discoid lupus erythematosus: A trichoscopic perspective

2013 ◽  
Vol 5 (4) ◽  
pp. 204 ◽  
Author(s):  
BalachandraS Ankad ◽  
SavithaL Beergouder ◽  
VishnuM Moodalgiri
Keyword(s):  
Lupus Erythematosus ◽  
Discoid Lupus Erythematosus ◽  
Lichen Planopilaris

scholarly journals The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Xiang-Tian Meng ◽  
Yun-Yue Shi ◽  
Hong Zhang ◽  
Hong-Yan Zhou
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Lupus Erythematosus ◽  
Th17 Cells ◽  
Allergic Conjunctivitis ◽  
Interleukin 17 ◽  
Type I ◽  
T Helper ◽  
Th2 Immune Response

Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.

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