Treatment of recalcitrant subcorneal pustular dermatosis with guselkumab

2020 ◽  
Author(s):  
Yuichi Teraki ◽  
Sora Sugai
Keyword(s):  
Subcorneal Pustular Dermatosis

scholarly journals Pustular Rash in Crohn’s Patient on Ustekinumab Raises Concern for Drug-Induced Paradoxical Psoriasis

2021 ◽  
pp. 662-666
Author(s):  
Mitra Barahimi ◽  
Scott Lee ◽  
Kindra Clark-Snustad
Keyword(s):  
Side Effect ◽  
De Novo ◽  
Pustular Psoriasis ◽  
Initial Weight ◽  
Drug Induced ◽  
Clinical Recurrence ◽  
Potential Side Effect ◽  
First Case ◽  
Tnf Antagonist ◽  
Subcorneal Pustular Dermatosis

We report the case of a 51-year-old male with Crohn’s disease (CD) who developed a reproducible pustular rash after ustekinumab (UST) administration. The patient first presented with a pustular rash on his hands, body, extremities, and scalp starting 5 weeks after his initial weight-based UST induction. The rash resolved spontaneously, then recurred 4 weeks after his first subcutaneous maintenance dose of UST 90 mg. Biopsy of the affected area demonstrated subcorneal pustular dermatosis (SPD). UST was discontinued and the rash resolved. Unfortunately, the patient experienced clinical recurrence of CD, and given prior failure of multiple CD medications, UST was restarted with premedication. Two weeks after UST re-induction, the rash recurred, though less severe. Given improvement in CD symptoms, UST was continued and the rash managed with topical corticosteroids. This is the first case of drug-induced SPD associated with UST. One case report has previously described de novo pustular psoriasis associated with UST in a patient with CD and enteropathic arthritis. Notably, SPD and pustular psoriasis can be histologically indistinguishable. The development of a paradoxical psoriasiform rash is thought to be one of the few dose and duration dependent side effects of TNF-antagonist therapy but has not previously been established as a side effect of UST. This case demonstrates a new potential side effect of UST.

Subcorneal pustular dermatosis successfully treated with low‐dose doxycycline

2021 ◽  
Author(s):  
Francesco Borgia ◽  
Alessio Campitiello ◽  
Luca Di Bartolomeo ◽  
Roberta Cardia ◽  
Ilenia Marafioti ◽  
...  
Keyword(s):  
Low Dose ◽  
Subcorneal Pustular Dermatosis

Subcorneal Pustular Dermatosis Associated with Palmo-Plantar Pustular Psoriasis: Response to Colchicine Therapy

2004 ◽  
Vol 31 (11) ◽  
pp. 946-948 ◽  
Author(s):  
Christina Stefanaki ◽  
George Kontochristopoulos ◽  
Simeon Kedikoglou ◽  
Eutychia Hatziolou ◽  
Niki Zakopoulou
Keyword(s):  
Pustular Psoriasis ◽  
Subcorneal Pustular Dermatosis ◽  
Colchicine Therapy

Rapid response of IgA pemphigus of subcorneal pustular dermatosis type to treatment with isotretinoin

2000 ◽  
Vol 43 (5) ◽  
pp. 923-926 ◽  
Author(s):  
Claus Gruss ◽  
Detlef Zillikens ◽  
Takashi Hashimoto ◽  
Masayuki Amagai ◽  
Maximilian Kroiss ◽  
...  
Keyword(s):  
Rapid Response ◽  
Iga Pemphigus ◽  
Subcorneal Pustular Dermatosis

Successful treatment of subcorneal pustular dermatosis with maxacalcitol

2015 ◽  
Vol 41 (1) ◽  
pp. 102-103 ◽  
Author(s):  
D. Hoshina ◽  
M. Tsujiwaki ◽  
K. Furuya
Keyword(s):  
Successful Treatment ◽  
Subcorneal Pustular Dermatosis
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