Role of hepatosteatosis in HBsAg seroconversion in HBeAg‐negative chronic hepatitis B patients

2021 ◽  
Author(s):  
Ferhat Bacaksız ◽  
Hale Gökcan ◽  
Meral Akdoğan ◽  
Dilara Turan Gökçe ◽  
Derya Arı ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hbsag Seroconversion ◽  
Negative Chronic Hepatitis

scholarly journals Role of quantitative hepatitis B surface antigen in predicting inactive carriers and HBsAg seroclearance in HBeAg-negative chronic hepatitis B patients

Medicine ◽  
2017 ◽  
Vol 96 (13) ◽  
pp. e6554 ◽  
Author(s):  
Teerapat Ungtrakul ◽  
Tassanee Sriprayoon ◽  
Pattama Kusuman ◽  
Pitchayachuda Chunnuan ◽  
Kamonwan Soonklang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Hbsag Seroclearance ◽  
Negative Chronic Hepatitis

scholarly journals The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Malihe Moradzadeh ◽  
Sirous Tayebi ◽  
Hossein Poustchi ◽  
Kourosh Sayehmiri ◽  
Parisa Shahnazari ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Direct Sequencing ◽  
Innate Immune ◽  
Enzyme Linked Immunosorbent Assay ◽  
B Virus ◽  
Toll Like Receptor 2 ◽  
Negative Chronic Hepatitis

Recognition mechanisms of innate immune response help to improve immunotherapeutic strategies in HBeAg-negative chronic hepatitis B (CHB). Toll-like receptor 2 (TLR2) is an important component of innate immunity. In this study, the frequency of precore mutations of the hepatitis B virus (HBV) and serum TLR2 were evaluated in CHB patients. Fifty-one patients with chronic hepatitis B, negative for HBeAg and detectable HBV DNA, were examined for the presence of mutations in pre-core region of HBV genome by direct sequencing. Serum TLR2 was measured by enzyme-linked immunosorbent assay. Interactions of truncated HBeAg and TLR2 proteins were evaluated with molecular docking software. The G1896A pre-core mutation were detected in 29 (57%) which was significantly associated with higher concentration of serum TLR2 in comparison with patients without this mutation (4.8±2.9 versus 3.4±2.2 ng/mL,P=0.03). There was also a significant correlation between serum ALT and TLR-2 (r=0.46;P=0.01). Docking results illustrated residues within the N-terminus of truncated HBeAg and TLR2, which might facilitate the interaction of these proteins. These findings showed the dominance of G1896A pre-core mutation of HBV variants in this community which was correlated with serum TLR2. Moreover TLR2 is critical for induction of inflammatory cytokines and therefore ALT elevation.

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