Zirconium modified calcium‐silicate‐based nanoceramics: An in vivo evaluation in a rabbit tibial defect model

2018 ◽  
Vol 16 (2) ◽  
pp. 431-437 ◽  
Author(s):  
Ali Doostmohammadi ◽  
Zahra Karimzadeh Esfahani ◽  
Abdolreza Ardeshirylajimi ◽  
Zahra Rahmati Dehkordi
Keyword(s):  
Calcium Silicate ◽  
Defect Model ◽  
In Vivo Evaluation ◽  
Tibial Defect

In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model

Biomaterials ◽  
2004 ◽  
Vol 25 (20) ◽  
pp. 5037-5044 ◽  
Author(s):  
D. Stubbs ◽  
M. Deakin ◽  
P. Chapman-Sheath ◽  
W. Bruce ◽  
J. Debes ◽  
...  
Keyword(s):  
Bone Graft ◽  
Defect Model ◽  
In Vivo Evaluation ◽  
Tibial Defect ◽  
Bone Graft Substitutes

Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model

2019 ◽  
Vol 108 (3) ◽  
pp. 1107-1116 ◽  
Author(s):  
Willams T. Barbosa ◽  
Katilayne V. Almeida ◽  
Gabriel G. Lima ◽  
Miguel A. Rodriguez ◽  
Marcos V. Lia Fook ◽  
...  
Keyword(s):  
Bone Repair ◽  
Defect Model ◽  
In Vivo Evaluation ◽  
Tibial Defect

Fabrication of hybrid scaffolds by polymer deposition system and its in-vivo evaluation with a rat tibial defect model

2014 ◽  
Vol 11 (6) ◽  
pp. 439-445 ◽  
Author(s):  
Min-Woo Sa ◽  
Sung Eun Kim ◽  
Young-Pil Yun ◽  
Hae-Ryong Song ◽  
Jong Young Kim
Keyword(s):  
Defect Model ◽  
In Vivo Evaluation ◽  
Tibial Defect ◽  
Polymer Deposition ◽  
Hybrid Scaffolds

scholarly journals In Vivo Evaluation of 3D-Printed Polycaprolactone Scaffold Implantation Combined with β-TCP Powder for Alveolar Bone Augmentation in a Beagle Defect Model

Materials ◽  
2018 ◽  
Vol 11 (2) ◽  
pp. 238 ◽  
Author(s):  
Su Park ◽  
Hyo-Jung Lee ◽  
Keun-Suh Kim ◽  
Sang Lee ◽  
Jung-Tae Lee ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Bone Augmentation ◽  
Defect Model ◽  
In Vivo Evaluation ◽  
3D Printed

In vivo evaluation of interactions between biphasic calcium phosphate (BCP)-niobium pentoxide (Nb2O5) nanocomposite and tissues using a rat critical-size calvarial defect model

2020 ◽  
Vol 31 (8) ◽  
Author(s):  
Helio de Jesus Kiyochi Junior ◽  
Aline Gabriela Candido ◽  
Taiana Gabriela Moretti Bonadio ◽  
José Adauto da Cruz ◽  
Mauro Luciano Baesso ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Critical Size ◽  
Niobium Pentoxide ◽  
Calvarial Defect ◽  
Defect Model ◽  
In Vivo Evaluation

scholarly journals In Vitro and In Vivo Evaluation of Commercially Available Fibrin Gel as a Carrier of Alendronate for Bone Tissue Engineering

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Beom Su Kim ◽  
Feride Shkembi ◽  
Jun Lee
Keyword(s):  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Release Kinetics ◽  
Human Mesenchymal Stem Cells ◽  
Calvarial Defect ◽  
Defect Model ◽  
Fibrin Gel ◽  
In Vivo Evaluation

Alendronate (ALN) is a bisphosphonate drug that is widely used for the treatment of osteoporosis. Furthermore, local delivery of ALN has the potential to improve the bone regeneration. This study was designed to investigate an ALN-containing fibrin (fibrin/ALN) gel and evaluate the effect of this gel on both in vitro cellular behavior using human mesenchymal stem cells (hMSCs) and in vivo bone regenerative capacity. Fibrin hydrogels were fabricated using various ALN concentrations (10−7–10−4 M) with fibrin glue and the morphology, mechanical properties, and ALN release kinetics were characterized. Proliferation and osteogenic differentiation of and cytotoxicity in fibrin/ALN gel-embedded hMSCs were examined. In vivo bone formation was evaluated using a rabbit calvarial defect model. The fabricated fibrin/ALN gel was transparent with Young’s modulus of ~13 kPa, and these properties were not affected by ALN concentration. The in vitro studies showed sustained release of ALN from the fibrin gel and revealed that hMSCs cultured in fibrin/ALN gel showed significantly increased proliferation and osteogenic differentiation. In addition, microcomputed tomography and histological analysis revealed that the newly formed bone was significantly enhanced by implantation of fibrin/ALN gel in a calvarial defect model. These results suggest that fibrin/ALN has the potential to improve bone regeneration.

IN VIVO EVALUATION OF A NEW β-TRICALCIUM PHOSPHATE BONE SUBSTITUTE IN A RABBIT FEMUR DEFECT MODEL

2015 ◽  
Vol 27 (03) ◽  
pp. 1550028 ◽  
Author(s):  
Kam-Kong Chan ◽  
Chia-Hsien Chen ◽  
Lien-Chen Wu ◽  
Yi-Jie Kuo ◽  
Chun-Jen Liao ◽  
...  
Keyword(s):  
Bone Graft ◽  
Tricalcium Phosphate ◽  
Bone Substitute ◽  
Zealand White Rabbit ◽  
Bone Substitutes ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
In Vivo Evaluation ◽  
Rabbit Femur

Calcium phosphate ceramics, of a similar composition to that of mineral bone, and which possess the properties of bioactivity and osteoconductivity, have been widely used as substitutes for bone graft in orthopedic, plastic and craniofacial surgeries. A synthetic β-tricalcium phosphate, Osteocera™, a recently developed bone graft substitute, has been used in this study. To evaluate the affinity and efficacy of Osteocera™ as bone defect implant, we used a New Zealand white rabbit femur defect model to test the osteoconductivity of this new bone substitute. Alternative commercially available bone substitutes, Triosite® and ProOsteon500, were used as the control materials. These three bone substitutes show good biocompatibility, and no abnormal inflammation either infection was seen at the implantation sites. In the histological and histomorphometric images, newly formed bone grew into the peripheral pores in the bone substitutes. After six months implantation, the volume of bone formation was found to be 20.5 ± 5.2%, 29.8 ± 6.5% and 75.5 ± 4.9% of the potential total cavity offered by ProOsteon500, Triosite® and Osteocera™, respectively. The newly formed bone area within the femur defect section for Osteocera™ was significantly larger than ProOsteon500 and Triosite®. We concluded that Osteocera™ shows better bioresorbability, biocompatibility and osteoconductivity in the rabbit femur defect model.

In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats

2015 ◽  
Vol 124 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Kadriye Demirkaya ◽  
Birsen Can Demirdöğen ◽  
Zeynep Öncel Torun ◽  
Onur Erdem ◽  
Serdar Çetinkaya ◽  
...  
Keyword(s):  
Calcium Silicate ◽  
In Vivo Evaluation

scholarly journals In vivo efficacy and toxicity of synthesized nano-β-tricalcium phosphate in a rabbit tibial defect model

2018 ◽  
Vol 2 ◽  
pp. 239784731881949
Author(s):  
Jer Ping Ooi ◽  
Shah Rizal Kasim ◽  
Rumaizi Bin Shaari ◽  
Nor Aini Saidin
Keyword(s):  
Inflammatory Response ◽  
Tricalcium Phosphate ◽  
Histopathological Examination ◽  
Healing Process ◽  
Control Group ◽  
Precipitation Process ◽  
Defect Model ◽  
Defect Site ◽  
Tibial Defect

Previous studies of the biocompatibility of β-tricalcium phosphate (β-TCP) focused on bulk-sized β-TCP, and little is known about the biocompatibility of nano β-TCP particles (nβ-TCP). The objectives of this study were to synthesize nβ-TCP particles and determine their efficacy in a rabbit tibial defect model. The nβ-TCP particles were first synthesized using a wet chemical precipitation process. The particles were then implanted in the left tibia of New Zealand white rabbits, and the defect site healing was evaluated for a period of 16 weeks using radiography, computed tomography, and histology. Data were compared with those of a sham (empty) control. Results showed that the defect site treated with nβ-TCP particles did not heal completely after 16 weeks, whereas full cortical bone recovery was observed in the sham control group of rabbits. Histopathological examination showed that the nβ-TCP particles caused an excessive and prolonged inflammatory response by the host. The nano-scaled size and biodegradability of the synthesized nβ-TCP particles may have been responsible for this progressive and extended inflammatory response, which delayed the bone healing process. The underlying mechanism for this effect remains unclear and warrants further investigation.

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