Analysis of hard tissue regeneration and Wnt signalling in dental pulp tissues after direct pulp capping with different materials

2019 ◽  
Vol 52 (11) ◽  
pp. 1605-1616 ◽  
Author(s):  
K. Yaemkleebbua ◽  
T. Osathanon ◽  
N. Nowwarote ◽  
C. N. Limjeerajarus ◽  
W. Sukarawan
Keyword(s):  
Tissue Regeneration ◽  
Dental Pulp ◽  
Wnt Signalling ◽  
Direct Pulp Capping ◽  
Hard Tissue ◽  
Pulp Capping

Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping

2012 ◽  
Vol 529-530 ◽  
pp. 543-546
Author(s):  
Mariko Nakamura ◽  
Yasuhiro Yoshida ◽  
Yoshihiro Ito
Keyword(s):  
Soft Tissue ◽  
Visible Light ◽  
Dental Pulp ◽  
Dental Materials ◽  
Direct Pulp Capping ◽  
Hard Tissue ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Dental Pulp Tissue

Direct pulp capping involves the application of dental materials to the exposed pulp in an attempt to act as a barrier, protect the dental pulp complex and preserve its vitality. The materials for direct pulp capping should ideally adhere to dental pulp tissue as soft tissue and dentin as hard tissue with tight sealing. We therefore developed visible light-induced crosslinkable gelatin which is capable of adhesive to soft tissue and hard tissue.

scholarly journals Dexamethasone - loaded polymeric porous sponge as a hard tissue regeneration agent

2020 ◽  
Author(s):  
Amjad Alagha
Keyword(s):  
Stem Cells ◽  
Inflammatory Response ◽  
Tissue Regeneration ◽  
Animal Experiment ◽  
Direct Pulp Capping ◽  
Hard Tissue ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Odontoblast Differentiation

Abstract Background : The aim of this study is to achieve the principles of tissue engineering using biopolymers to be applied in the field of vital endodontic treatment with the aim of stimulating stem cells and engineering and regeneration of dentin tissue. the blend was loaded with the steroidal anti-inflammatory drug, dexamethasone, and the porous drug-loaded bio-sponge was produced by lyophilization. Bio-sponge, as a direct pulp capping agent, was histologically studied compared to calcium hydroxide Ca(OH)2 in an animal experiment. Results: The results indicated the effectiveness of the bio-sponge as a direct pulp agent, where the dentin bridge was formed faster than Ca(OH)2 treated samples,. There was no inflammatory response in the pulp tissue throughout the follow-up period. Conclusions : The porous bio-sponge loaded with dexamethasone with a neutral pH resulted in enhancement the odontoblast differentiation from stem cells, resulted in the formation of a renewed dentin bridge without the slightest inflammatory response in the pulp.

scholarly journals Melatonin as an Agent for Direct Pulp-Capping Treatment

2020 ◽  
Vol 17 (3) ◽  
pp. 1043 ◽  
Author(s):  
Julia Guerrero-Gironés ◽  
Antonia Alcaina-Lorente ◽  
Clara Ortiz-Ruiz ◽  
Eduardo Ortiz-Ruiz ◽  
María P. Pecci-Lloret ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dental Pulp ◽  
Bone Growth ◽  
Study Groups ◽  
Histological Evaluation ◽  
Sprague Dawley ◽  
Direct Pulp Capping ◽  
Pulp Capping ◽  
Reparative Dentin ◽  
Pulp Inflammation

Melatonin plays an essential role in the regulation of bone growth. The actions that melatonin exerts on odontoblasts may be similar to its action on osteoblasts. This research aimed to evaluate the pulp response to melatonin used for direct pulp capping to evaluate the antioxidant effect of melatonin administered orally and its influence on dental pulp. Direct pulp capping was performed on the upper molars of Sprague Dawley rats using melatonin or Mineral Trioxide Aggregate (MTA). The study groups were: MTA; Melatonin; MTA + Melatonin administered orally; and Melatonin + Melatonin administered orally. In the latter two groups, the animals drank water dosed with melatonin ad libitum (10 mg/100 mL). After 30 days, the animals were sacrificed, and 5 ml of blood, the kidneys, and the liver were extracted in order to evaluate oxidative stress using thiobarbituric acid reactive substances testing (TBARS). Fragments of the maxilla containing the study molars were prepared for histological evaluation. The degree of pulp inflammation and pulp necrosis, the presence of reparative dentin and dentin bridging the pulp chamber, the presence and regularity of the odontoblastic layer, and the presence of pulp fibrosis were evaluated. No significant differences were found between the four study groups for any of the studied histological variables. The oral administration of melatonin did not modify the local effects of MTA or melatonin on dental pulp, or reduce basal-level oxidative stress. The effect of melatonin on pulp is similar to that of MTA and may be used as an agent for direct pulp capping.

scholarly journals Evaluation of β-catenin expression in dental pulp following direct pulp capping in dog teeth

2018 ◽  
Vol 64 (1) ◽  
pp. 745-752
Author(s):  
Dalia El-Baz ◽  
Maha El-Baz ◽  
Geraldine Ahmed ◽  
Alaa El-Baz
Keyword(s):  
Dental Pulp ◽  
Direct Pulp Capping ◽  
Pulp Capping

scholarly journals DEFENCE REACTION IN DENTAL PULP AFTER PULP CAPPING AND PARTIAL PULPECTOMY IN DOGS

2000 ◽  
Vol 48 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Z. Pavlica ◽  
M. Pogačnik ◽  
Polona Juntes
Keyword(s):  
Dental Pulp ◽  
Zinc Phosphate ◽  
Direct Pulp Capping ◽  
Defence Reaction ◽  
Pulp Capping ◽  
Single Root ◽  
Pulp Inflammation ◽  
Radical Method ◽  
Indirect Pulp Capping

The dental pulp was capped indirectly or directly, or partial vital pulpectomy was performed on the 12 functionally most important teeth of 24 beagle dogs. For pulp capping, calcium hydroxide was used, followed by zinc phosphate as a lining, and the preparation was restored with amalgam or composite material. Histological sections were prepared and examined for degree and type of pulp inflammation (hyperaemia, pulpitis, necrosis or gangrene). Degenerative changes of dental pulp (vacuolation, calcification, amyloid or hyaline changes) were also determined. For indirect pulp capping the width of predentine in crown and root dental pulp was measured, and for direct pulp capping and partial pulpectomy (vital pulpotomy) the width and quality of the dentinal bridge were graded. The radical method of partial vital pulpectomy of the coronal part of the dental pulp in dogs produced better quality and continuity of the dentinal bridge than the less radical method of direct pulp capping. This was particularly obvious in small single root teeth such as incisors.

scholarly journals Hard tissue formation after direct pulp capping with osteostatin and MTA in vivo

2021 ◽  
Vol 46 ◽  
Author(s):  
Ji-Hye Yoon ◽  
Sung-Hyeon Choi ◽  
Jeong-Tae Koh ◽  
Bin-Na Lee ◽  
Hoon-Sang Chang ◽  
...  
Keyword(s):  
Tissue Formation ◽  
Direct Pulp Capping ◽  
Hard Tissue ◽  
Pulp Capping
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