Effectiveness of CPP‐ACP and Fluoride Products in Tooth Remineralization.

2021 ◽  
Author(s):  
Patrícia Regina Almeida de Oliveira ◽  
Luísa Schubach da Costa Barreto ◽  
Mônica Almeida Tostes
Keyword(s):  
Tooth Remineralization

scholarly journals O Uso de Partículas Remineralizantes em Odontologia: uma Alternativa na Abordagem Minimamente Invasiva

2018 ◽  
Vol 19 (5) ◽  
pp. 166
Author(s):  
M S C Sales ◽  
V F Passos ◽  
R G L A Ferreira ◽  
N J C Sena ◽  
W A Morais
Keyword(s):  
Dental Enamel ◽  
Tooth Remineralization

O objetivo deste trabalho foi, por meio de uma revisão de literatura, avaliar a utilização de partículas remineralizantes no combate a desmineralização e a capacidade delas de promover uma abordagem minimamente invasiva. Para isto, foi realizada uma pesquisa nas bases de dados Pubmed, Scielo e Science Direct, com os descritores “tooth remineralization”, “dentin” e “dental enamel”. Foram encontrados 95 artigos em inglês, publicados entre 2008 e 2017. A partir disso, foram selecionados 13 artigos, excluindo   os de revisão de literatura e os incompatíveis com a temática em pesquisa. Segundo estudo, nanopartículas de hidroxiapatita (HA) atuam remineralizando as lesões cariosas, tendo efeito 2,7 vezes maior em dentina do que em esmalte. A utilização de fosfato de cálcio amorfo-fosfopepitídeo caseína (CPP-ACP) tem potencial para prevenir a desmineralização e para aumentar a remineralização em esmalte, pois aumenta a concentração de íons cálcio e fosfato, levando a um estado supersaturado. Além disso, o fosfosilicato de cálcio e sódio (CSP) é um biovidro que, em contato com fluidos, libera íons que resultam em formação de HA e é efetivo na remineralização de dentina. Portanto, a utilização de materiais biofuncionais que propiciem íons cálcio e fosfato tem sido eficiente como remineralizantes, permitindo uma abordagem mais conservadora em odontologia. Sendo então, a aplicação dessas partículas, vantajosa e promissora para prevenir e tratar a desmineralização dentária, possibilitando a remoção parcial do tecido cariado passível de remineralização.Palavras-chave: Remineralização Dentária. Dentina. Esmalte Dentário.

scholarly journals Determination of chemical elements and cross-section hardness of sclerotic darkened human dentin

2017 ◽  
Vol 20 (3) ◽  
Author(s):  
Mauricio Yugo Souza ◽  
Laura Celia Fernandes Meirelles ◽  
Isabela Roberta Vieira Duque ◽  
Mariane Cintra Mailart ◽  
Taciana Marco Ferraz Caneppele ◽  
...  
Keyword(s):  
Cross Section ◽  
Chemical Elements ◽  
Human Teeth ◽  
Significance Level ◽  
X Ray ◽  
Tooth Remineralization ◽  
Human Dentin ◽  
Knoop Microhardness ◽  
Mg Content

<p><strong>Objective</strong>: The aim of this study was to assess the amount of chemical elements (Ca, O, C, P, Fe, and Mg) and the cross-section hardness of sclerotic darkened dentin in human teeth. <strong>Material</strong> <strong>and</strong> <strong>Methods</strong>: The study was approved by the local IRB and ten extracted teeth (five sound and five presenting sclerotic darkened dentin) were used. Tooth was sectioned mesiodistally and each half was used for each test. Amount of chemical elements (%w) was determined by energy dispersive X-ray spectroscopy (EDS) in three different dentin areas (shallow, medium, or deep sound or sclerotic dentin). Knoop microhardness was determined at the same EDS areas. Data were analyzed by two-way ANOVA and multiple comparison tests, with significance level at 5%. <strong>Results</strong>: No difference on microhardness was detected between sound and sclerotic dentin (p = 0.743) and also among dentin depths (p = 0.837). Lower Ca (p = 0.024) and higher C (p = 0.015) amounts were found at superficial sclerotic dentin. Increased Mg content (p &lt; 0.001) was detected in sound dentin. <strong>Conclusion</strong>: It was concluded darkened sclerotic dentin presents similar cross-section microhardness to sound dentin. The assessed chemical elements were similarly present in sound or sclerotic dentin, except for Mg, which was present higher concentration in sound dentin. Ca and P were lower in superficial sclerotic dentin.</p><p> </p><p><strong>Keywords: </strong>Dentin; Hardness; Minerals; Tooth Remineralization.</p>

scholarly journals Sugar Alcohols, Caries Incidence, and Remineralization of Caries Lesions: A Literature Review

2010 ◽  
Vol 2010 ◽  
pp. 1-23 ◽  
Author(s):  
Kauko K. Mäkinen
Keyword(s):  
Clinical Trials ◽  
Dental Caries ◽  
Literature Review ◽  
Sugar Alcohol ◽  
Sugar Alcohols ◽  
Enamel Defects ◽  
Oh Groups ◽  
Tooth Remineralization ◽  
Dentin Caries ◽  
Caries Lesions

Remineralization of minor enamel defects is a normal physiological process that is well known to clinicians and researchers in dentistry and oral biology. This process can be facilitated by various dietary and oral hygiene procedures and may also concern dentin caries lesions. Dental caries is reversible if detected and treated sufficiently early. Habitual use of xylitol, a sugar alcohol of the pentitol type, can be associated with significant reduction in caries incidence and with tooth remineralization. Other dietary polyols that can remarkably lower the incidence of caries include erythritol which is a tetritol-type alditol. Based on known molecular parameters of simple dietary alditols, it is conceivable to predict that their efficacy in caries prevention will follow the homologous series, that is, that the number of OH-groups present in the alditol molecule will determine the efficacy as follows: . The possible difference between erythritol and xylitol must be confirmed in future clinical trials.

Tooth remineralization using bio-active glass - A novel approach

2011 ◽  
Vol 2 (2) ◽  
pp. 45-50 ◽  
Author(s):  
Natasha Madan ◽  
Neeraj Madan ◽  
Vikram Sharma ◽  
Deepak Pardal ◽  
Nidhi Madan
Keyword(s):  
Tooth Remineralization ◽  
Novel Approach

scholarly journals Remineralização de Esmalte Através da Incorporação de Nanopartículas em Materiais Resinosos: Revisão de Literatura

2018 ◽  
Vol 19 (5) ◽  
pp. 31
Author(s):  
A M Nascimento ◽  
D M De-Paula ◽  
N J C Sena ◽  
V P Feitosa ◽  
A C F Costa ◽  
...  
Keyword(s):  
Resin Cements ◽  
Tooth Remineralization

O objetivo deste trabalho é uma revisão da literatura sobre a remineralização de esmalte através da incorporação de nanopartículas (NP) em materiais resinosos (MR). Para isso, foi feita uma busca na base de dados Pubmed, utilizando os descritores “nanoparticles”, “tooth remineralization” e “resin cements”. Foram encontrados 133 artigos, nos anos de 2007 a 2017, sendo utilizados 25, a partir dos critérios de inclusão (artigos no idioma inglês e estudos com nanopartículas inclusas em MR) e de exclusão (artigos de revisão de literatura e sistemática). Os estudos analisados indicam que adesivo dental com NP de fosfato de cálcio amorfo (FCA) pode remineralizar e inibir cárie a longo prazo. Adição de cargas silanizadas em resinas compostas experimentais com FCA mostra melhoria na deposição mineral. Ionômero de vidro modificado por resina com NP mostrou apenas efeito protetor em relação ao desafio cariogênico. Adesivo com NP cristalinas de titânio promove propriedades remineralizante e bactericida fotocatalítica. Tratamento com nanohidroxiapatita de estrôncio indica um padrão de deposição de cristais melhorado em comparação com qualquer outra modalidade. Os resultados apresentados são promissores para futuras tecnologias dentais, mas precisam ser testados clinicamente.Palavras-chave: Nanoparticles. Tooth Remineralization. Resin Cements.

scholarly journals The Use of Resinous Infiltrants for the Management of Incipient Carious Lesions: a Literature Review

2019 ◽  
Vol 21 (4) ◽  
pp. 358
Author(s):  
Jéssica Delazari Ferreira ◽  
Mariana Dias Flor-Ribeiro ◽  
Giselle Maria Marchi ◽  
Flávia Bittencourt Pazinatto
Keyword(s):  
Dental Caries ◽  
Literature Review ◽  
Minimally Invasive ◽  
Scientific Evidence ◽  
Minimally Invasive Treatment ◽  
Invasive Treatment ◽  
Tooth Remineralization ◽  
Carious Lesions ◽  
Long Term Studies

AbstractThe objective of this work was to analyze scientific evidence from a literature review pertaining to the effectiveness of resinous infiltrants for minimally invasive treatment of incipient carious lesions. Studies published between 2002 and 2019 were queried from the following databases: Capes, PubMed, Medline, BBO, Lilacs and SciELO. The search keywords included "Dental Caries", "Tooth Remineralization", "Dental Leakage". Most of the studies found resin-infiltrating treatment to be a viable option for the minimally invasive treatment of incipient carious lesions; this treatment was able to fulfill the primary expected effects: inhibition of carious progression and the lesions esthetic improvement. However, some issues need to be clarified to improve the safety of this treatment because it can be recommended in clinical practice. In conclusion, the use of resinous infiltrants has been reported as promising for the treatment of incipient carious lesions. However, there is a need for long-term studies to confirm the effectiveness of this treatment to determine its applicability for clinical use. Keywords: Dental Caries. Dental Leakage. Tooth Remineralization. ResumoO objetivo desse trabalho foi analisar evidências científicas, por meio de uma revisão de literatura, sobre a eficácia do uso de infiltrantes resinosos para o tratamento minimamente invasivo de lesões cariosas incipientes. A seleção do material literário utilizado foi realizada por pesquisa sobre o tema nas bases de dados: portal de periódicos Capes, PubMed, Medline, BBO, Lilacs e SciELO, abrangendo prioritariamente, o período de 2002 a 2019. Para busca nas bases de dados foram utilizadas palavras-chave como “Cárie Dentária”, “Remineralização Dentária”, “Infiltração Dentária”, assim como suas correspondentes na língua inglesa.  A maioria dos estudos encontrados aponta o tratamento infiltrante resinoso como uma opção viável para o tratamento minimamente invasivo de lesões cariosas incipientes sendo capaz de cumprir os principais efeitos esperados: inibição da progressão cariosa e melhoria estética das lesões. Entretanto, alguns impasses necessitam ser esclarecidos para que o tratamento seja recomendado com mais segurança na prática clínica. Conclui-se que o uso de infiltrantes resinosos tem sido relatado como promissor para o tratamento de lesões cariosas incipientes, contudo há necessidade de novas pesquisas e estudos a longo prazo para confirmar sua eficácia em todos aspectos desejáveis para seu uso clínico. Palavras-chave: Cárie Dentária. Infiltração Dentária. Remineralização Dentária.

scholarly journals The effect of pasteurized milk and pure soy milk on enamel remineralization

2019 ◽  
Vol 31 (3) ◽  
pp. 202
Author(s):  
Annesha Metly ◽  
Dedi Sumantri ◽  
Fadil Oenzil
Keyword(s):  
Tooth Enamel ◽  
Hardness Test ◽  
Hardness Measurement ◽  
Control Group ◽  
P Value ◽  
Soy Milk ◽  
Control Group Design ◽  
Pasteurized Milk ◽  
Tooth Remineralization ◽  
Milk Tooth

Introduction: Tooth remineralization agent can be found in pasteurized milk and soy milk. Ca2+ and PO43- ions concentration in both products inhibited hydroxyapatite dissolution and enhanced remineralization. This study was aimed to investigate the effect of pasteurized milk and pure soy milk on tooth enamel remineralization. Methods: This study was an experimental laboratory with pre-test post-test control group design. Twenty-seven maxillary premolars were divided into 3 groups; 37% phosphoric acid used to demineralized the samples followed by initial enamel hardness measurement. All samples were immersed in aquadest, pasteurized milk, and pure soy milk for 14 days, 102 minutes per day. Final enamel hardness was measured with the Vickers hardness test. Results: Increasing enamel hardness was found in all groups. Two-way ANOVA test was used to compare the increase of enamel hardness in all group, which showed the p-value = 0.002. Post-hoc LSD test was then used to compare the increase of the enamel hardness in pasteurized milk and pure soy milk groups, which resulted in the p-value = 0.147. Conclusion: There was an effect of pasteurized milk and pure soy milk group on enamel remineralization. However, there was no difference in the increase of enamel hardness value between pasteurized milk and pure soy milk groups.Keywords: Pasteurized milk, pure soy milk, tooth enamel, remineralization.

Polydopamine-Induced Tooth Remineralization

2012 ◽  
Vol 4 (12) ◽  
pp. 6901-6910 ◽  
Author(s):  
Yun-Zhi Zhou ◽  
Ying Cao ◽  
Wei Liu ◽  
Chun Hung Chu ◽  
Quan-Li Li
Keyword(s):  
Tooth Remineralization

Characterization and Preparation of Calcium Phosphate Model Toothpaste for Tooth Enamel Remineralization

2016 ◽  
Vol 721 ◽  
pp. 213-218 ◽  
Author(s):  
Vita Zalite ◽  
Janis Locs
Keyword(s):  
Calcium Phosphate ◽  
Tooth Enamel ◽  
Calcium Phosphates ◽  
Tooth Remineralization ◽  
Calcium Phosphate Layer ◽  
Thixotropic Behaviour ◽  
Water Viscosity ◽  
S Model ◽  
Surface Changes

Calcium phosphates are excellent biomaterial for hard tissue regeneration and replacement. Recently, nanohydroxylapatite (HAp) has been intensively studied as remineralization agent for tooth enamel protection and remineralization. In this research, we developed model toothpaste composition, determined viscosity and investigated weather different processed – spray-dried (spCDHAp), lyophilized (lyoCDHAp), wet precipitated (paste-like consistence, pCDHAp) – calcium deficient hydroxyapatite (CDHAp) affect bovine tooth enamel remineralization. Model toothpastes components were CDHAp, 2-hydroxyethylcelluloce, glycerol and water. Viscosity varied from 2.5 to 40 Pa∙s. Model toothpastes with 20 wt% CDHAp showed thixotropic behaviour, thereby we examined them as potential tooth remineralization pastes. After in vitro remineralization enamel surface changes were detected, the texture of demineralized surface and bundles of HAp crystals were not observed. It was suggested, that new calcium phosphate layer was formed on the enamel. In conclusion, CDHAp is very promising material for enamel regeneration, but different pretreatment of CDHAp (resulting as different morphology of agglomerates) did not give distinctive remineralization results.

scholarly journals Rehardening of Eroded Enamel with CPP-ACFP Paste and CO2 Laser Treatment

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Shahin Kasraei ◽  
Parmis Kasraei ◽  
Sara Valizadeh ◽  
Mohadeseh Azarsina
Keyword(s):  
Laser Irradiation ◽  
Co2 Laser ◽  
Surface Hardness ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Treatment Modalities ◽  
Control Group ◽  
Tooth Remineralization

Background. Diet and lifestyle can destroy tooth structure due to the dissolution of enamel by acidic beverages. The present study evaluated the effect of CO2 laser irradiation and CPP-ACFP (casein phosphopeptide and amorphous calcium phosphate with fluoride) paste on the remineralization of enamel eroded by carbonated soft drinks. Methods. In the present in vitro study, 46 human sound premolar teeth were sectioned mesiodistally to achieve 84 samples. Fourteen samples were assigned to the positive control group (G1), and the remaining samples were immersed in 500 mL of cola drink for 2 minutes, followed by rinsing with distilled water for 10 seconds. This procedure was carried out three times to create erosive lesions. Then, the 60 eroded samples were randomly assigned to five groups of G2 to G6 in terms of the treatment as follows: negative control (G2), CO2 laser irradiation (G3), CPP-ACFP paste (G4), CO2 laser irradiation followed by CPP-ACFP paste application (G5), and CPP-ACFP paste application followed by CO2 laser irradiation (G6). The mean surface microhardness of the enamel surface was evaluated and determined at three points for each sample. Data were analyzed with one-way ANOVA and Tukey HSD tests ( α = 0.05 ). Results. The highest and the lowest hardness values were recorded in the G1 ( 314 ± 12  kg/mm2) and G2 ( 213.7 ± 12  kg/mm2) groups, respectively. ANOVA revealed significant differences between the study groups ( P < 0.001 ). Two-by-two comparisons showed significant differences between the G2 group and the other groups, indicating the efficacy of all the treatment modalities in tooth remineralization and rehardening procedures ( P < 0.05 ). Only in group G6, the enamel microhardness was not significantly different from the G1 positive control group ( P > 0.05 ). Conclusion. Considering the parameters used in the present study, CO2 laser irradiation or CPP-ACFP paste application alone increased eroded enamel’s surface hardness; however, their sequential application was more effective in rehardening the eroded enamel’s surface to near-normal levels.

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