p16 Immunoexpression in sinonasal and nasopharyngeal adenoid cystic carcinomas: a potential pitfall in ruling out HPV‐related multiphenotypic sinonasal carcinoma

2020 ◽  
Vol 77 (6) ◽  
pp. 989-993 ◽  
Author(s):  
Vijay M Antony ◽  
Aanchal Kakkar ◽  
Kapil Sikka ◽  
Alok Thakar ◽  
Suryanarayan V S Deo ◽  
...  
Keyword(s):  
Potential Pitfall ◽  
Sinonasal Carcinoma ◽  
Adenoid Cystic ◽  
Multiphenotypic Sinonasal Carcinoma

HPV-Related Multiphenotypic Sinonasal Carcinoma: A Unique Case

2019 ◽  
Vol 27 (8) ◽  
pp. 888-892 ◽  
Author(s):  
Daniel Ching ◽  
Shadi Pirasteh ◽  
Chanh Ly
Keyword(s):  
Salivary Gland ◽  
Human Papillomavirus ◽  
High Grade ◽  
Salivary Gland Carcinoma ◽  
Unique Case ◽  
Sinonasal Carcinoma ◽  
Adenoid Cystic ◽  
Gland Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma ◽  
High Risk Hpv

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a recently described neoplasm that presents only in the sinonasal tract, displays features of both a surface-derived carcinoma and a salivary gland carcinoma, and is associated with high-risk HPV, specifically HPV type 33. Majority of the cases display high-grade histologic features, but HMSC paradoxically behaves in a relatively indolent fashion. Distinguishing HMSC from other histologic mimickers is essential as the management and prognosis are significantly different. In this article, we present a unique case of HMSC and review the literature.

HPV-Related Multi-Phenotypic Sinonasal Carcinoma with Aggressive Clinical Behavior; A Rare Case

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S82-S83
Author(s):  
L Ha ◽  
Q Sadiq ◽  
J Singh ◽  
F Khan
Keyword(s):  
High Risk ◽  
Adenoid Cystic Carcinoma ◽  
Nerve Fibers ◽  
Sinonasal Carcinoma ◽  
Adenoid Cystic ◽  
Architectural Patterns ◽  
Sinonasal Mass ◽  
Multiphenotypic Sinonasal Carcinoma ◽  
High Risk Hpv

Abstract Introduction/Objective Human Papilloma Virus (HPV)-related multiphenotypic sinonasal carcinoma, previously known as HPV-related sinonasal carcinoma with adenoid cystic carcinoma-like features, is a rare type of sinonasal carcinoma with both epithelial-derived and salivary gland-type morphologic features. It is associated with high-risk HPV, but lacks MYB gene rearrangements. Methods/Case Report We report a case of a 59-year-old male who presented with a rapidly growing sinonasal mass. On MRI, a left nasal cavity lesion was identified growing laterally along the frontal process of the maxilla, extending into the middle meatus and into the maxillary sinus. Patient underwent a complex left medial maxillectomy, spheno- ethmoidectomy, and sinusotomy. On gross evaluation, the left inferior turbinate and sidewall demonstrated a 4 cm unremarkable turbinate with attached friable soft tissue. Microscopic examination revealed sections of carcinoma with various architectural patterns comprised of foci with adenoid cystic carcinoma-like morphology, basaloid squamous cell carcinoma and adenocarcinoma. The tumor showed positive immunostaining for P40, but focal reactivity to S100 and rare scattered reactivity with CD117. INI-1 immunostain was retained in tumor cells. P16 immunostain was strong and diffuse and high-risk cocktail HPV RNA ISH was positive. However, MYB FISH testing was equivocal. Morphologic and immunophenotypic findings were consistent with HPV-related multiphenotypic sinonasal carcinoma. The tumor involved the olfactory nerve fibers requiring a skull base resection and showed extension into the dura mater. Results (if a Case Study enter NA) NA Conclusion HPV related multiphenotypic sinonasal carcinoma is a recently described entity that can pose significant diagnostic challenge. It typically has an indolent clinical course with potential for late recurrences. This case study highlights the potential aggressive nature of this type of sinonasal carcinoma, despite association with high-risk HPV, and use of ancillary testing in aiding diagnosis.

scholarly journals HPV-related Multiphenotypic Sinonasal Carcinoma

2017 ◽  
Vol 41 (12) ◽  
pp. 1690-1701 ◽  
Author(s):  
Justin A. Bishop ◽  
Simon Andreasen ◽  
Jen-Fan Hang ◽  
Martin J. Bullock ◽  
Tiffany Y. Chen ◽  
...  
Keyword(s):  
Sinonasal Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma

Human papillomavirus-related multiphenotypic sinonasal carcinoma

2021 ◽  
Author(s):  
Yohei Morishita ◽  
Shingo Sakashita ◽  
Toshifumi Tomioka ◽  
Wataru Okano ◽  
Takeshi Shinozaki ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Sinonasal Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma

scholarly journals Human papillomavirus-related multiphenotypic sinonasal carcinoma: a clinico-pathological dilemma case report

2021 ◽  
Vol 39 ◽  
Author(s):  
Nouha Ben Abdeljelil ◽  
Samiha Mabrouk ◽  
Souheil Khalfaoui ◽  
Mahdi Farjaoui ◽  
Ahlem Bellalah ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Case Report ◽  
Sinonasal Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma

scholarly journals Human Papillomavirus–Related Carcinoma With Adenoid Cystic–like Features of the Sinonasal Tract (Also Known as Human Papillomavirus–Related Multiphenotypic Sinonasal Carcinoma)

2019 ◽  
Vol 143 (11) ◽  
pp. 1420-1424 ◽  
Author(s):  
Chia-Chi Chen ◽  
Sheau-Fang Yang
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Hpv Infection ◽  
Myoepithelial Cells ◽  
Sinonasal Tract ◽  
Surface Epithelium ◽  
Ductal Cells ◽  
Adenoid Cystic ◽  
Multiphenotypic Sinonasal Carcinoma ◽  
High Risk Hpv

Human papillomavirus (HPV)–related carcinoma with adenoid cystic–like features is a rare, recently recognized entity restricted to the sinonasal tract. By definition, it is associated with high-risk HPV infection, particularly with HPV type 33. In most cases, tumors are composed of dual cell populations, including predominant basaloid myoepithelial cells and usually inconspicuous ductal cells. Solid components with focal cribriform or tubular patterns, abrupt keratinization within tumor nests, and squamous dysplasia of the surface epithelium are characteristics of HPV-related carcinoma with adenoid cystic–like features. The immunohistochemistry of p16 followed by high-risk HPV testing may help in the differential diagnosis. Recent studies have demonstrated that the morphologic features of this entity are more diverse than initially believed. Surgical resection is the prime alternative for treatment. According to the limited data, the prognosis of this disease may be better than that of other sinonasal carcinomas.

HPV‐Related Multiphenotypic Sinonasal Carcinoma: A Case Report and Literature Review

2020 ◽  
Vol 131 (1) ◽  
pp. 106-110
Author(s):  
Matthew L. Ward ◽  
Mikelle Kernig ◽  
Thomas J. Willson
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Sinonasal Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma
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