Somatic tumour testing establishes that bilateral DICER1 ‐associated ovarian Sertoli–Leydig cell tumours represent independent primary neoplasms

2020 ◽  
Vol 77 (2) ◽  
pp. 223-230
Author(s):  
W Glenn McCluggage ◽  
Anne‐Laure Chong ◽  
Leanne Kock ◽  
William D Foulkes
Keyword(s):  
Leydig Cell ◽  
Primary Neoplasms ◽  
Leydig Cell Tumours

NEW VIEWS ON THE HORMONE-PRODUCING MESENCHYMOMAS OF THE OVARIES

1960 ◽  
Vol XXXV (IV) ◽  
pp. 513-517
Author(s):  
W. P. Plate
Keyword(s):  
Granulosa Cell ◽  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Tumour ◽  
Theca Cell ◽  
Granulosa Cell Tumour ◽  
Sertoli Cell Tumours ◽  
Leydig Cell Tumours

ABSTRACT The hormone-producing mesenchymomas of the ovaries can be divided into androblastomas and gynaecoblastomas. The former are derived from »male« elements, and consist of Sertoli-cell tumours and Leydig-cell tumours. The latter arise from »female« elements and consist of granulosacell tumours and theca-cell tumours. Sertoli-cell tumours and granulosacell tumours produce oestrogens, while Leydig-cell tumours and theca-cell tumours produce oestrogens or androgens. Histologically, androblastomas and gynaecoblastomas are often difficult to distinguish. Since no »female« elements occur in a testicle, a granulosa-cell tumour in a testicle is improbable. Gynandroblastomas, therefore, can only be found in an ovary.

Spermatogenesis and testicular tumours in ageing dogs

Reproduction ◽  
2000 ◽  
pp. 443-452 ◽  
Author(s):  
MA Peters ◽  
DG de Rooij ◽  
KJ Teerds ◽  
I van Der Gaag ◽  
FJ van Sluijs
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Seminiferous Tubules ◽  
Score System ◽  
Testicular Tumours ◽  
Severe Impairment ◽  
Per Se ◽  
Testicular Disease ◽  
Sertoli Cell Tumours ◽  
Leydig Cell Tumours

Spermatogenesis was examined in testes from 74 dogs of various breeds without clinically detected testicular disease. A modified Johnsen score system was used to determine whether spermatogenesis deteriorates with ageing. The diameter of seminiferous tubules was measured in dogs without testicular disease to examine other possible effects of ageing on tubular performance. There appeared to be no relation between age and these variables. The influence of testicular tumours on spermatogenesis was also investigated in both affected and unaffected testes. The testes of 28 dogs with clinically palpable tumours and 21 dogs with clinically non-palpable tumours were investigated. In cases of unilateral occurrence of a tumour, impairment of spermatogenesis was observed only in the affected testis of dogs with clinically detected tumours. Bilateral occurrence of tumours, whether detected clinically or non-clinically, was associated with severe impairment of spermatogenesis. The prevalence of tumours increased during ageing. Eighty-six per cent of the clinically detected and 57% of the non-clinically detected tumours were found in old dogs. Multiple types of tumour and bilateral occurrence were very common. Seminomas and Leydig cell tumours were more frequent than Sertoli cell tumours. It was concluded that spermatogenesis per se did not decrease during ageing in dogs but the occurrence of testicular tumours increased with ageing and affected spermatogenesis significantly, as reflected by a lower Johnsen score.

Leydig Cell Tumours: a Case Series from a Single Irish Centre

2021 ◽  
Author(s):  
Hailey K. Carroll ◽  
Tom Nolis ◽  
Waseem Darwish ◽  
Michele Harrison ◽  
John A. McCaffrey
Keyword(s):  
Leydig Cell ◽  
Case Series ◽  
Leydig Cell Tumours

scholarly journals Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
B. Wormald ◽  
S. Elorbany ◽  
H. Hanson ◽  
J. W. Williams ◽  
S. Heenan ◽  
...  
Keyword(s):  
Case Report ◽  
Gene Mutation ◽  
Leydig Cell ◽  
Autosomal Dominant ◽  
Review Of The Literature ◽  
Autosomal Dominant Fashion ◽  
Rare Tumours ◽  
Leydig Cell Tumour ◽  
Underlying Pathology ◽  
Leydig Cell Tumours

Sertoli-Leydig cell tumours of the ovary (SLCT) are rare tumours predominantly caused by mutations in the DICER1 gene. We present a patient with a unilateral SLCT who had an underlying germline DICER1 gene mutation. We discuss the underlying pathology, risks, and screening opportunities available to those with a mutation in this gene as SLCT is only one of a multitude of other tumours encompassing DICER1 syndrome. The condition is inherited in an autosomal dominant fashion. As such, genetic counselling is a key component of the management of women with SLCT.

Diagnostic pitfalls in ovarian androgen-secreting (Leydig cell) tumours: case series

2018 ◽  
Vol 39 (3) ◽  
pp. 359-364
Author(s):  
M. Fanta ◽  
D. Fischerová ◽  
T. Indrielle-Kelly ◽  
P. Koliba ◽  
A. Zdeňková ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Case Series ◽  
Diagnostic Pitfalls ◽  
Leydig Cell Tumours

Loss of gender difference in serum leptin levels and its slow recovery after successful surgery for Leydig cell tumours in two virilized females

2001 ◽  
Vol 54 (5) ◽  
pp. 693-697 ◽  
Author(s):  
S. Pekic ◽  
S. Vujovic ◽  
S. Spremovic-Radjenovic ◽  
M. Petakov ◽  
M. Djurovic ◽  
...  
Keyword(s):  
Gender Difference ◽  
Leydig Cell ◽  
Slow Recovery ◽  
Serum Leptin ◽  
Leydig Cell Tumours

Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys

2018 ◽  
Vol 91 ◽  
pp. 125-135 ◽  
Author(s):  
Adriana María Belén Abiuso ◽  
María Luisa Varela ◽  
Luis Haro Durand ◽  
Marcos Besio Moreno ◽  
Alejandra Marcos ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Therapeutic Target ◽  
Histamine H4 Receptor ◽  
Prepubertal Boys ◽  
H4 Receptor ◽  
Leydig Cell Tumours ◽  
Novel Therapeutic

scholarly journals Non-tumoural parenchyma in Leydig cell tumours: pathogenetic considerations

2008 ◽  
Vol 31 (3) ◽  
pp. 331-336 ◽  
Author(s):  
M. M. Cajaiba ◽  
M. Reyes-Múgica ◽  
J. C. S. Rios ◽  
M. Nistal
Keyword(s):  
Leydig Cell ◽  
Pathogenetic Considerations ◽  
Leydig Cell Tumours
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