Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys

2018 ◽  
Vol 91 ◽  
pp. 125-135 ◽  
Author(s):  
Adriana María Belén Abiuso ◽  
María Luisa Varela ◽  
Luis Haro Durand ◽  
Marcos Besio Moreno ◽  
Alejandra Marcos ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Therapeutic Target ◽  
Histamine H4 Receptor ◽  
Prepubertal Boys ◽  
H4 Receptor ◽  
Leydig Cell Tumours ◽  
Novel Therapeutic

Histamine H4 Receptor: A Novel Therapeutic Target for Immune and Allergic Responses

2010 ◽  
Vol 10 (14) ◽  
pp. 1293-1308 ◽  
Author(s):  
H. G. Bhatt ◽  
Y. K. Agrawal ◽  
H. G. Raval ◽  
K. Manna ◽  
P. R. Desai
Keyword(s):  
Therapeutic Target ◽  
Histamine H4 Receptor ◽  
H4 Receptor ◽  
Novel Therapeutic

Atypical presentation of Leydig cell tumour in three prepubertal patients: diagnosis, treatment and outcomes

2019 ◽  
Vol 32 (4) ◽  
pp. 369-374 ◽  
Author(s):  
Miriam García González ◽  
Isabel Casal-Beloy ◽  
Iván Somoza Argibay ◽  
Teresa Dargallo Carbonell
Keyword(s):  
Leydig Cell ◽  
Tumour Size ◽  
Atypical Presentation ◽  
Key Factors ◽  
Precocious Pseudopuberty ◽  
Leydig Cell Tumour ◽  
Prepubertal Boys ◽  
Hormonal Action ◽  
Leydig Cell Tumours

Abstract Background Testicular tumours are uncommon in children, accounting for only 1% of all childhood tumours. Prepubertal Leydig cell tumours actively secrete testosterone and as a result, patients typically present with isosexual precocious pseudopuberty, this being the first cause of consultation. We present three cases of Leydig cell tumours in prepubertal patients with an atypical presentation. Methods We studied three cases of Leydig cell tumours in prepubertal boys, who either consulted for testicular asymmetry or were incidentally found to have the tumour in the absence of systemic signs of systemic hyperandrogenism or precocious puberty. In all cases, a well-circumscribed testicular mass was found by testicular ultrasound. The diagnosis was confirmed by histology. In all three cases, testicular enucleation was performed with satisfactory follow-up. Results Following the surgical procedure, during the follow-up, all patients showed a normal testicular volume in comparison with the contralateral testis. No complications were seen during follow-up. Conclusions A testicular ultrasound in children developing asymptomatic testicular asymmetry might be recommended due to its possible hormonal action locally. An early testicular ultrasound, testicular swelling discrepancies, tumour size and androgen production are key factors in the prognosis and management of this type of tumour.

scholarly journals H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells

2014 ◽  
Vol 223 (3) ◽  
pp. 241-253 ◽  
Author(s):  
Adriana María Belén Abiuso ◽  
Esperanza Berensztein ◽  
Romina María Pagotto ◽  
Elba Nora Pereyra ◽  
Vanina Medina ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Leydig Cells ◽  
Cell Function ◽  
Scientific Publications ◽  
Histamine H4 Receptor ◽  
Proliferative Effect ◽  
Male Gametes ◽  
Specific Localization ◽  
Normal Rat ◽  
H4 Receptor

The histamine H4 receptor (HRH4), discovered only 13 years ago, is considered a promising drug target for allergy, inflammation, autoimmune disorders and cancer, as reflected by a steadily growing number of scientific publications and patent applications. Although the presence of HRH4 has been evidenced in the testis, its specific localization or its role has not been established. Herein, we sought to identify the possible involvement of HRH4 in the regulation of Leydig cell function. We first evaluated its expression in MA-10 Leydig tumor cells and then assessed the effects of two HRH4 agonists on steroidogenesis and proliferation. We found that HRH4 is functionally expressed in MA-10 cells, and that its activation leads to the inhibition of LH/human chorionic gonadotropin-induced cAMP production and StAR protein expression. Furthermore, we observed decreased cell proliferation after a 24-h HRH4 agonist treatment. We then detected for the sites of HRH4 expression in the normal rat testis, and detected HRH4 immunostaining in the Leydig cells of rats aged 7–240 days, while 21-day-old rats also presented HRH4 expression in male gametes. Finally, we evaluated the effect of HRH4 activation on the proliferation of normal progenitor and immature rat Leydig cell culture, and both proved to be susceptible to the anti-proliferative effect of HRH4 agonists. Given the importance of histamine (2-(1H-imidazol-4-yl)ethanamine) in human (patho)physiology, continued efforts are directed at elucidating the emerging properties of HRH4 and its ligands. This study reveals new sites of HRH4 expression, and should be considered in the design of selective HRH4 agonists for therapeutic purposes.

NEW VIEWS ON THE HORMONE-PRODUCING MESENCHYMOMAS OF THE OVARIES

1960 ◽  
Vol XXXV (IV) ◽  
pp. 513-517
Author(s):  
W. P. Plate
Keyword(s):  
Granulosa Cell ◽  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Tumour ◽  
Theca Cell ◽  
Granulosa Cell Tumour ◽  
Sertoli Cell Tumours ◽  
Leydig Cell Tumours

ABSTRACT The hormone-producing mesenchymomas of the ovaries can be divided into androblastomas and gynaecoblastomas. The former are derived from »male« elements, and consist of Sertoli-cell tumours and Leydig-cell tumours. The latter arise from »female« elements and consist of granulosacell tumours and theca-cell tumours. Sertoli-cell tumours and granulosacell tumours produce oestrogens, while Leydig-cell tumours and theca-cell tumours produce oestrogens or androgens. Histologically, androblastomas and gynaecoblastomas are often difficult to distinguish. Since no »female« elements occur in a testicle, a granulosa-cell tumour in a testicle is improbable. Gynandroblastomas, therefore, can only be found in an ovary.

Spermatogenesis and testicular tumours in ageing dogs

Reproduction ◽  
2000 ◽  
pp. 443-452 ◽  
Author(s):  
MA Peters ◽  
DG de Rooij ◽  
KJ Teerds ◽  
I van Der Gaag ◽  
FJ van Sluijs
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Seminiferous Tubules ◽  
Score System ◽  
Testicular Tumours ◽  
Severe Impairment ◽  
Per Se ◽  
Testicular Disease ◽  
Sertoli Cell Tumours ◽  
Leydig Cell Tumours

Spermatogenesis was examined in testes from 74 dogs of various breeds without clinically detected testicular disease. A modified Johnsen score system was used to determine whether spermatogenesis deteriorates with ageing. The diameter of seminiferous tubules was measured in dogs without testicular disease to examine other possible effects of ageing on tubular performance. There appeared to be no relation between age and these variables. The influence of testicular tumours on spermatogenesis was also investigated in both affected and unaffected testes. The testes of 28 dogs with clinically palpable tumours and 21 dogs with clinically non-palpable tumours were investigated. In cases of unilateral occurrence of a tumour, impairment of spermatogenesis was observed only in the affected testis of dogs with clinically detected tumours. Bilateral occurrence of tumours, whether detected clinically or non-clinically, was associated with severe impairment of spermatogenesis. The prevalence of tumours increased during ageing. Eighty-six per cent of the clinically detected and 57% of the non-clinically detected tumours were found in old dogs. Multiple types of tumour and bilateral occurrence were very common. Seminomas and Leydig cell tumours were more frequent than Sertoli cell tumours. It was concluded that spermatogenesis per se did not decrease during ageing in dogs but the occurrence of testicular tumours increased with ageing and affected spermatogenesis significantly, as reflected by a lower Johnsen score.

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