Next‐generation sequencing of endoscopic ultrasound guided microbiopsies from pancreatic cystic neoplasms

2019 ◽  
Vol 75 (5) ◽  
pp. 767-771 ◽  
Author(s):  
Charlotte Vestrup Rift ◽  
Linea C Melchior ◽  
Bojan Kovacevic ◽  
Anders Toxværd ◽  
Pia Klausen ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Endoscopic Ultrasound ◽  
Next Generation ◽  
Ultrasound Guided ◽  
Cystic Neoplasms ◽  
Pancreatic Cystic Neoplasms ◽  
Generation Sequencing

Utility of Endoscopic Ultrasound-Guided Biopsy for Next-Generation Sequencing of Pancreatic Exocrine Malignancies

Pancreas ◽  
2018 ◽  
Vol 47 (8) ◽  
pp. 990-995 ◽  
Author(s):  
Brent K. Larson ◽  
Richard Tuli ◽  
Laith H. Jamil ◽  
Simon K. Lo ◽  
Nan Deng ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Endoscopic Ultrasound ◽  
Next Generation ◽  
Ultrasound Guided ◽  
Guided Biopsy ◽  
Pancreatic Exocrine ◽  
Generation Sequencing ◽  
Ultrasound Guided Biopsy

scholarly journals New Era of Endoscopic Ultrasound-Guided Tissue Acquisition: Next-Generation Sequencing by Endoscopic Ultrasound-Guided Sampling for Pancreatic Cancer

2019 ◽  
Vol 8 (8) ◽  
pp. 1173 ◽  
Author(s):  
Imaoka ◽  
Sasaki ◽  
Hashimoto ◽  
Watanabe ◽  
Ikeda
Keyword(s):  
Pancreatic Cancer ◽  
Next Generation Sequencing ◽  
Endoscopic Ultrasound ◽  
Next Generation ◽  
Ultrasound Guided ◽  
Tissue Samples ◽  
Genomic Biomarkers ◽  
Tissue Acquisition ◽  
Chemotherapy Patients ◽  
Generation Sequencing

Pancreatic cancer is a lethal cancer with an increasing incidence. Despite improvements in chemotherapy, patients with pancreatic cancer continue to face poor prognoses. Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is the primary method for obtaining tissue samples of pancreatic cancer. Due to advancements in next-generation sequencing (NGS) technologies, multiple parallel sequencing can be applied to EUS-TA samples. Genomic biomarkers for therapeutic stratification in pancreatic cancer are still lacking, however, NGS can unveil potential predictive genomic biomarkers of treatment response. Thus, the importance of NGS using EUS-TA samples is becoming recognized. In this review, we discuss the recent advances in EUS-TA application for NGS of pancreatic cancer.

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