Clinicopathological factors associated withBRAF‐V600E mutation in colorectal serrated adenomas

2019 ◽  
Vol 75 (2) ◽  
pp. 160-173 ◽  
Author(s):  
Antonio Travaglino ◽  
Francesco P D'Armiento ◽  
Gianluca Cassese ◽  
Maria R Campanino ◽  
Giorgio Borrelli ◽  
...  
2021 ◽  
Author(s):  
Francesca Magnoni ◽  
Giovanni Corso ◽  
Laura Gilardi ◽  
Eleonora Pagan ◽  
Giulia Massari ◽  
...  

Aims: The clinical significance of nonvisualized sentinel lymph nodes (non-vSLNs) is unknown. The authors sought to determine the incidence of non-vSLNs on lymphoscintigraphy, the identification rate during surgery, factors associated with non-vSLNs and related axillary management. Patients & methods: A total of 30,508 consecutive SLN procedures performed at a single institution from 2000 to 2017 were retrospectively studied. Associations between clinicopathological factors and the identification of SLNs during surgery were assessed. Results: Non-vSLN occurred in 525 of the procedures (1.7%). In 73.3%, at least one SLN was identified intraoperatively. Nodal involvement was only significantly associated with SLN nonidentification (p < 0.001). Conclusion: Patients with non-vSLN had an increased risk for SLN metastasis. The detection rate during surgery was consistent, reducing the amount of unnecessary axillary dissection.


Medicine ◽  
2018 ◽  
Vol 97 (34) ◽  
pp. e11999 ◽  
Author(s):  
Zengwei Tang ◽  
Yuan Yang ◽  
Zhonghong Zhao ◽  
Kongyuan Wei ◽  
Wenbo Meng ◽  
...  

2019 ◽  
Vol 19 (7) ◽  
pp. 549-552
Author(s):  
Serric Suthesh Willeam Peter ◽  
Sharifah Syed Hassan ◽  
Victoria Phooi Khei Tan ◽  
Chin Fang Ngim ◽  
Nur Amelia Azreen Adnan ◽  
...  

2021 ◽  
Vol 37 (2) ◽  
pp. 33-41
Author(s):  
Jang Gyu Han ◽  
Seung-il Kim ◽  
Bumhee Park ◽  
Jeon Yeob Jang ◽  
Yoo Seob Shin ◽  
...  

Background/Objectives: Extra-nodal extension (ENE) is one of the strongest prognosticators in oral cancers. Here we tried to evaluate clinicopathological factors associated with the presence of ENE.Materials & Methods: We retrospectively analyzed clinical information of 120 patients who diagnosed with oral cancer and received curative surgery at our hospital from Mar 2012 to Apr 2020. We comparatively analyzed clinicopathological factors associated with the presence of lymph node (LN) metastasis and ENE, respectively.Results: Variable factors of primary tumor characteristics such as lymphovascular invasion, perineural invasion, largest diameter of tumor, depth of invasion and maximum standardized uptake value were significantly associated with the presence of cervical LN metastasis. The largest diameter of tumor was statistically significant also in multivariate analysis for predicting the LN metastasis. Meanwhile, the association between primary tumor characteristics and the presence of ENE were not statistically significant except the primary tumor size. Importantly, factors associated with LN characteristics including the maximum diameter and number of metastatic LNs were significantly associated with ENE.Conclusion: In this study, several factors affecting cervical LN metastasis and ENE in oral cancer patients were identified. The ENE seems to be influenced by the status of the metastatic LNs, such as the number of metastatic LNs, rather than the characteristics of the primary tumor itself.


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