scholarly journals The Clinicopathological Factors Associated with Multicentricity in Papillary Thyroid Cancer

2016 ◽  
Vol 7 (4) ◽  
Author(s):  
Murat Ozgur Kilic
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Clinicopathological Factors ◽  
Papillary Thyroid ◽  
Factors Associated

Male Patients With Papillary Thyroid Cancer Have a Higher Risk of Extranodal Extension

2021 ◽  
Author(s):  
Hu Hei ◽  
Bin Zhou ◽  
Wenbo Gong ◽  
Chen Zheng ◽  
Jianwu Qin
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Multivariable Analysis ◽  
Underlying Mechanism ◽  
Clinicopathological Factors ◽  
Papillary Thyroid ◽  
Extranodal Extension ◽  
Increased Risk ◽  
Male Patients ◽  
Male Sex

Abstract Purpose: There is a sex disparity in papillary thyroid cancer (PTC). Male sex is associated with a higher likelihood of advanced stage disease. This study aimed to examine the significance of sex for extranodal extension (ENE) in PTC. Patients and Methods: We reviewed the data of PTC patients who had undergone initial surgical resection from July 2012 to December 2014 (N = 1531). The effects of sex and other clinicopathological factors on ENE were investigated.Results: Of 1531 patients identified, 377 (24.6%) were male, 816 (53.3%) had positive nodes, and 256 (16.7%) had ENE. Compared with female patients, male patients had a higher risk of ENE (P < 0.001). Multivariable analysis of clinicopathological factors revealed that male sex (odds ratio [OR], 1.98; 95% confidence interval [CI], 1.37 - 2.87; P < 0.001), age older than 60 years (OR, 1.93; 95% CI, 1.08 - 3.35; P = 0.023), extrathyroidal extension (OR, 3.52; 95% CI, 2.42 - 5.14; P < 0.001), bilateral multifocality (OR, 2.18; 95% CI, 1.53 - 3.13; P < 0.001), and more positive nodes were significantly associated with increased risk of ENE. Patients with 6-10 positive nodes were 16.45-fold higher to have ENE than patients with 5 positive nodes or less (95% CI, 11.07 - 24.68; P < 0.001).Conclusion: Male PTC patients had a higher risk of ENE than female. Sex was an independent predictor of ENE. The underlying mechanism needs to be investigated further.

scholarly journals Risk Factor Stratification of Lung Metastasis in Children and Adolescent Papillary Thyroid Cancer

2021 ◽  
Author(s):  
Liying Wang ◽  
Feng Liu ◽  
Lingyun Zhang ◽  
Shu Rui ◽  
Yang Liu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Lung Metastasis ◽  
Independent Risk Factor ◽  
Significant Risk ◽  
Response To Therapy ◽  
Papillary Thyroid ◽  
Children And Adolescent ◽  
Factors Associated

Abstract Background: Lung metastasis (LM) in pediatric papillary thyroid cancer (pPTC) is significantly higher than in adults. While spare information about pPTC and LM hampers to formulate specific guideline. Hence, we retrospectively analyzed the whole pPTCs in our center to investigate factors associated with LM and therapy outcomes.Materials and Methods: PTCs with age＜20 years who received initial operations in ourcenterfrom December 2008 to December 2018 were retrospectively reviewed. Clinicopathological information, treatment pipelineand outcomes were analyzed retrospectively.Results:Totally, 114 pPTC patients were enrolled in our study, LM was observed in 17 (14.9 %) cases. Significant risk factors associated with LM were age, sex, tumor size, multifocality, extrathyroidal extension, lymph node metastasis, number of metastatic lymph nodes (NMLNs)and postoperative stimulated thyroglobulin (sTg). NMLNs ＞14 was identified as an independent risk factor for LM by multivariate analysis (OR 25.166, 95% CI 2.814 - 225.009, p = 0.004) with a sensitivity of 86.7% and specificity of 81.1% for LM, which was verified by integrated meta-analysis. In terms ofresponse to radioiodine treatment in LM, 2 cases reached ‘‘excellent’’ response. ‘‘Biochemically incomplete’’, ‘‘structurally incomplete’’ and “indeterminate” were in 3,12, 2 of 17 patients respectively. Postoperative sTg was correlated with the response to therapy of LM in pPTCs(p = 0.003).Conclusion: LM was frequently observed in pPTCs. NMLNs ＞14 was an independent risk factor for LM in our study and other cohorts, and postoperative sTg was a potential predictor for the therapy outcome of LM in pPTCs.

The relationship between clinicopathological factors and recurrence risk of papillary thyroid cancer

2020 ◽  
Author(s):  
Raimonda Klimaite ◽  
Dalia Dauksiene ◽  
Albertas Dauksa ◽  
Valdas Sarauskas ◽  
Rasa Verkauskiene ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Recurrence Risk ◽  
Clinicopathological Factors ◽  
Papillary Thyroid ◽  
The Relationship

Correlation between obesity and clinicopathological factors in patients with papillary thyroid cancer

Surgery Today ◽  
2014 ◽  
Vol 45 (6) ◽  
pp. 723-729 ◽  
Author(s):  
Shin-Hyuk Kim ◽  
Hyung Seok Park ◽  
Ki-Ho Kim ◽  
Ho Yoo ◽  
Byung-Joo Chae ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Clinicopathological Factors ◽  
Papillary Thyroid

Factors associated with receipt of adjuvant radioactive iodine in node-negative versus node-positive papillary thyroid cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e17695-e17695
Author(s):  
Ryaz Chagpar ◽  
Eren Berber ◽  
Jamie Mitchell ◽  
Joyce Shin ◽  
Judy Jin ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Radioactive Iodine ◽  
Papillary Thyroid ◽  
Node Negative ◽  
Factors Associated ◽  
Node Positive ◽  
Versus Node

scholarly journals Preoperative Factors Associated with Extrathyroidal Extension in Papillary Thyroid Cancer

2020 ◽  
Vol 9 (5) ◽  
pp. 256-262 ◽  
Author(s):  
Chi-Yu Kuo ◽  
Po-Sheng Yang ◽  
Ming-Nan Chien ◽  
Shih-Ping Cheng
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Tumor Size ◽  
Braf Mutation ◽  
Extrathyroidal Extension ◽  
Additive Models ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Factors Associated ◽  
Preoperative Factors

Objective: Extrathyroidal extension may not be accurately recognized during thyroidectomy and can increase the risk of positive margins and even recurrence. This study aimed to investigate the preoperative factors associated with extrathyroidal extension. Methods: We analyzed 887 patients with papillary thyroid cancer (PTC) who underwent surgery in the period of 2005–2017. Binary logistic regression analyses and generalized additive models were used to identify associations. Results: Minimal extrathyroidal extension was present in 233 (26%) patients and advanced extrathyroidal extension was found in 60 (7%) patients. Age, BMI, and tumor size were independent predictors of all or advanced extrathyroidal extension. Among the 493 patients whose BRAF mutation status was available, age (OR = 1.025), BMI (OR = 1.091), tumor size (OR = 1.544), and BRAF V600E mutation (OR = 2.311) were independently associated with extrathyroidal extension. Conclusions: Older age, a greater BMI, a larger tumor size, and presence of the BRAF mutation were predictive of extrathyroidal extension. These factors should be taken into consideration in decision-making before surgery is performed.

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