Pleomorphic giant cell carcinoma of the urinary bladder: an extreme form of tumour de-differentiation

2015 ◽  
Vol 68 (4) ◽  
pp. 533-540 ◽  
Author(s):  
Hemamali Samaratunga ◽  
Brett Delahunt ◽  
Lars Egevad ◽  
Michael Adamson ◽  
David Hussey ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Giant Cell Carcinoma ◽  
Extreme Form ◽  
Pleomorphic Giant Cell Carcinoma

Pleomorphic giant cell carcinoma of the urinary bladder

2009 ◽  
Vol 40 (10) ◽  
pp. 1461-1466 ◽  
Author(s):  
Antonio Lopez-Beltran ◽  
Ana Blanca ◽  
Rodolfo Montironi ◽  
Liang Cheng ◽  
Juan C. Regueiro
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Giant Cell Carcinoma ◽  
Pleomorphic Giant Cell Carcinoma

scholarly journals Pleomorphic Giant Cell Carcinoma of Urinary Bladder with Brain Metastases Despite Initial Response to Cisplatin and Gemcitabine: A Case Report

2020 ◽  
Vol 4 (3) ◽  
pp. 46-50
Author(s):  
Antonio Vega Vega ◽  
◽  
Fraser Simpson ◽  
Hemali Samaratunga ◽  
Antonio J. Vega-Garcia ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Brain Metastases ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Primary Tumour ◽  
Initial Response ◽  
Giant Cell Carcinoma ◽  
Carcinoma Of The Bladder ◽  
Pleomorphic Giant Cell Carcinoma

A 59-year-old male presented with haematuria and was diagnosed with pleomorphic giant cell carcinoma of the urinary bladder, a very rare variant of urothelial carcinoma. The tumour was staged at pT2N3M1 and the primary tumour was removed by transurethral resection, and nodal metastases were treated with the standard systemic cisplatin and gemcitabine for urothelial cell carcinoma of the bladder. This treatment rendered the tumour clinically undetectable. Despite this treatment the patient developed brain metastases which were not found until the patient presented with neurological symptoms. This is the first recorded case of brain metastases from pleomorphic giant cell carcinoma of the urinary bladder recorded in the literature. CT imaging of the brain should be considered in the follow-up in patients with this tumour.

Polyomavirus (BK)-associated pleomorphic giant cell carcinoma of the urinary bladder: a case report

2013 ◽  
Vol 209 (4) ◽  
pp. 255-259 ◽  
Author(s):  
Borislav A. Alexiev ◽  
John C. Papadimitriou ◽  
Toby C. Chai ◽  
Emilio Ramos ◽  
Paul N. Staats ◽  
...  
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Giant Cell Carcinoma ◽  
Polyomavirus Bk ◽  
Pleomorphic Giant Cell Carcinoma

Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features

2021 ◽  
Vol 52 ◽  
pp. 151719
Author(s):  
Ziad M. El-Zaatari ◽  
Jessica S. Thomas ◽  
Mukul K. Divatia ◽  
Steven S. Shen ◽  
Alberto G. Ayala ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Giant Cell ◽  
Rare Tumor ◽  
Giant Cell Carcinoma ◽  
Molecular Features ◽  
Pleomorphic Giant Cell Carcinoma

scholarly journals Pleomorphic Giant Cell Carcinoma of the Pancreas with Hepatic Metastases—Initially Presenting as a Benign Serous Cystadenoma: A Case Report and Review of the Literature

HPB Surgery ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Petrou Athanasios ◽  
Papalambros Alexandros ◽  
Brennan Nicholas ◽  
Karles Dimitrios ◽  
Bramis Kostantinos ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Pancreatic Neoplasm ◽  
Hepatic Metastases ◽  
Surgical Excision ◽  
Serous Cystadenoma ◽  
Giant Cell Carcinoma ◽  
Laparoscopic Biopsy ◽  
Pleomorphic Giant Cell Carcinoma

Introduction. Pleomorphic giant cell pancreatic cancer is a very rare and aggressive pancreatic neoplasm. A case of pleomorphic giant cell pancreatic cancer presenting as a cystic lesion and in association with a serous cystadenoma presents a unique case which has not been described before. Case Presentation. A 44-year-old alcoholic man presented with abdominal pain, vomiting, and weight loss. Initially, imaging suspected a pancreatic pseudocyst measuring 4.2 cm. Endoscopic ultrasound- (EUS-) guided fine-needle aspiration revealed a serous cystadenoma. With conservative intervention only (fluid resuscitation, analgesia, and antiemetics) the patient improved and was discharged under close observation. Follow-up scan at four months revealed minimal change. Three months later, he was admitted acutely. Repeat scans demonstrated mild cyst enlargement with new liver lesions. Laparoscopic biopsy revealed pleomorphic giant cell carcinoma with the organ of origin the pancreas. Conclusion. This unusual case highlights the challenges in managing pancreatic cystic lesions and emphasizes the importance of considering less common forms of pancreatic cystic masses when the findings are atypical for the presentation. Surgical excision in these cases over conservative steps may be the most appropriate management.

Abnormal Nuclear Structures (Micronuclei, Nucleoplasmic Bridges, and Nuclear Buds) in a Pleomorphic Giant Cell Carcinoma of the Stomach

2008 ◽  
Vol 32 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Rosario Alberto Caruso ◽  
Francesco Fedele ◽  
Pierluigi Consolo ◽  
Carmelo Luigiano ◽  
Antonio Venuti ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Giant Cell ◽  
Carcinoma Of The Stomach ◽  
Giant Cell Carcinoma ◽  
Nuclear Structures ◽  
Pleomorphic Giant Cell Carcinoma
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