Asynchronous glands in secretory pattern endometrium: clinical associations and immunohistological changes

2015 ◽  
Vol 67 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Colin J R Stewart ◽  
Chrianna Bharat ◽  
Robyn Leake
Keyword(s):  
Clinical Associations ◽  
Secretory Pattern

Clinically significant cognitive dysfunction in OEF/OIF/OND veterans: Prevalence and clinical associations.

2019 ◽  
Vol 33 (4) ◽  
pp. 534-546 ◽  
Author(s):  
Elizabeth Riley ◽  
Alex Mitko ◽  
Anna Stumps ◽  
Meghan Robinson ◽  
William Milberg ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Clinical Associations ◽  
Clinically Significant

Concommitant secretory pattern of prolactin and LH during the menstrual cycle

1988 ◽  
Vol 117 (4_Suppl) ◽  
pp. S80-S81 ◽  
Author(s):  
K. A. BRENSING ◽  
L. WILDT ◽  
G. LEYENDECKER
Keyword(s):  
Menstrual Cycle ◽  
Secretory Pattern

Autoantibodies in Pediatric SLE: Cluster Analysis and Clinical Associations, a Single Centre Cohort Study

2020 ◽  
Author(s):  
Siva Vyasam ◽  
Anu Punnen ◽  
Visalakshi Jeyaseelan ◽  
John Jude Prakash ◽  
Sathish Kumar
Keyword(s):  
Cluster Analysis ◽  
Cohort Study ◽  
Single Centre ◽  
Clinical Associations ◽  
Pediatric Sle

scholarly journals Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro

2021 ◽  
Vol 22 (2) ◽  
pp. 958
Author(s):  
Luca Tamò ◽  
Kleanthis Fytianos ◽  
Fabienne Caldana ◽  
Cedric Simillion ◽  
Anis Feki ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Critical Role ◽  
Organ Injury ◽  
Macrophage Phenotype ◽  
Gene Interaction Network ◽  
Tissue Repair And Regeneration ◽  
Secretory Pattern

Induced pluripotent stem cell secretome (iPSC-CM) mitigate organ injury and help in repair. Macrophages play a critical role in tissue repair and regeneration and can be directed to promote tissue repair by iPSC-CM, although the exact mechanisms are not known. In the current investigative study, we evaluated the possible mechanism by which iPSC-CM regulates the phenotype and secretory pattern of macrophages in vitro. Macrophages were obtained from human peripheral blood mononuclear cells and differentiated to various subpopulations and treated with either iPSC-CM or control media in vitro. Macrophage phenotype was assessed by flow cytometry, gene expression changes by qRT PCR and secretory pattern by multiplex protein analysis. The protein and gene interaction network revealed the involvement of Amyloid precursor protein (APP) and ELAV-like protein 1 (ELAVL-1) both present in the iPSC-CM to play an important role in regulating the macrophage phenotype and their secretory pattern. This exploratory study reveals, in part, the possible mechanism and identifies two potential targets by which iPSC-CM regulate macrophages and help in repair and regeneration.

scholarly journals Primary tumors from mucosal barrier organs drive unique eosinophil infiltration patterns and clinical associations

2020 ◽  
Vol 10 (1) ◽  
pp. 1859732
Author(s):  
Sharon Grisaru-Tal ◽  
Michal Itan ◽  
Daniel G Grass ◽  
Javier Torres-Roca ◽  
Steven A Eschrich ◽  
...  
Keyword(s):  
Mucosal Barrier ◽  
Eosinophil Infiltration ◽  
Primary Tumors ◽  
Clinical Associations

Can We Decrease Epicardial and Pericardial Fat in Patients With Diabetes?

2021 ◽  
pp. 107424842110069
Author(s):  
Emir M. Muzurović ◽  
Snežana Vujošević ◽  
Dimitri P. Mikhailidis
Keyword(s):  
Myocardial Dysfunction ◽  
Biologically Active ◽  
Therapeutic Interventions ◽  
Cvd Risk ◽  
Fat Deposits ◽  
Patients With Diabetes ◽  
Calorie Diet ◽  
Cv Disease ◽  
Secretory Pattern

Diabetes mellitus (DM) is a chronic and complex metabolic disorder and also an important cause of cardiovascular (CV) disease (CVD). Patients with type 2 DM (T2DM) and obesity show a greater propensity for visceral fat deposition (and excessive fat deposits elsewhere) and the link between adiposity and CVD risk is greater for visceral than for subcutaneous (SC) adipose tissue (AT). There is growing evidence that epicardial AT (EAT) and pericardial AT (PAT) play a role in the development of DM-related atherosclerosis, atrial fibrillation (AF), myocardial dysfunction, and heart failure (HF). In this review, we will highlight the importance of PAT and EAT in patients with DM. We also consider therapeutic interventions that could have a beneficial effect in terms of reducing the amount of AT and thus CV risk. EAT is biologically active and a likely determinant of CV morbidity and mortality in patients with DM, given its anatomical characteristics and proinflammatory secretory pattern. Consequently, modification of EAT/PAT may become a therapeutic target to reduce the CV burden. In patients with DM, a low calorie diet, exercise, antidiabetics and statins may change the quantity of EAT, PAT or both, alter the secretory pattern of EAT, improve the metabolic profile, and reduce inflammation. However, well-designed studies are needed to clearly define CV benefits and a therapeutic approach to EAT/PAT in patients with DM.

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