Autoantibodies in Pediatric SLE: Cluster Analysis and Clinical Associations, a Single Centre Cohort Study

2020 ◽  
Author(s):  
Siva Vyasam ◽  
Anu Punnen ◽  
Visalakshi Jeyaseelan ◽  
John Jude Prakash ◽  
Sathish Kumar
Keyword(s):  
Cluster Analysis ◽  
Cohort Study ◽  
Single Centre ◽  
Clinical Associations ◽  
Pediatric Sle

COVID-19 in Patients with Hepatobiliary and Pancreatic Diseases in East London: A Single-Centre Cohort Study

2020 ◽  
Author(s):  
Abu Z. M. Dayem Ullah ◽  
Lavanya Sivapalan ◽  
Claude Chelala ◽  
Hemant M. Kocher
Keyword(s):  
Cohort Study ◽  
Single Centre ◽  
Pancreatic Diseases

scholarly journals Trends in mortality of hospitalised COVID-19 patients: A single centre observational cohort study from Spain

2021 ◽  
Vol 3 ◽  
pp. 100041
Author(s):  
Carolina Garcia-Vidal ◽  
Alberto Cózar-Llistó ◽  
Fernanda Meira ◽  
Gerard Dueñas ◽  
Pedro Puerta-Alcalde ◽  
...  
Keyword(s):  
Cohort Study ◽  
Observational Cohort Study ◽  
Single Centre ◽  
Observational Cohort

scholarly journals Relation between body composition and severe diarrhea in patients treated with preoperative chemoradiation with capecitabine for rectal cancer: a single-centre cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
J. M. van Rees ◽  
W. Hartman ◽  
J. J. M. E. Nuyttens ◽  
E. Oomen-de Hoop ◽  
J. L. A. van Vugt ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rectal Cancer ◽  
Body Composition ◽  
Logistic Regression ◽  
Cohort Study ◽  
Preoperative Chemoradiation ◽  
Regression Analyses ◽  
Single Centre ◽  
Severe Diarrhea ◽  
The Impact

Abstract Background Chemoradiation with capecitabine followed by surgery is standard care for locally advanced rectal cancer (LARC). Severe diarrhea is considered a dose-limiting toxicity of adding capecitabine to radiation therapy. The aim of this study was to describe the risk factors and the impact of body composition on severe diarrhea in patients with LARC during preoperative chemoradiation with capecitabine. Methods A single centre retrospective cohort study was conducted in a tertiary referral centre. All patients treated with preoperative chemoradiation with capecitabine for LARC from 2009 to 2015 were included. Patients with locally recurrent rectal cancer who received chemoradiation for the first time were included as well. Logistic regression analyses were performed to identify risk factors for severe diarrhea. Results A total of 746 patients were included. Median age was 64 years (interquartile range 57–71) and 477 patients (64%) were male. All patients received a radiation dosage of 25 × 2 Gy during a period of five weeks with either concomitant capecitabine administered on radiation days or continuously during radiotherapy. In this cohort 70 patients (9%) developed severe diarrhea. In multivariable logistic regression analyses female sex (OR: 4.42, 95% CI 2.54–7.91) and age ≥ 65 (OR: 3.25, 95% CI 1.85–5.87) were the only risk factors for severe diarrhea. Conclusions Female patients and patients aged sixty-five or older had an increased risk of developing severe diarrhea during preoperative chemoradiation therapy with capecitabine. No relation was found between body composition and severe diarrhea.

Sign in / Sign up

Export Citation Format

Share Document