Zinc deficiency predicts overt hepatic encephalopathy and mortality in liver cirrhosis patients with minimal hepatic encephalopathy

2020 ◽  
Author(s):  
Takao Miwa ◽  
Tatsunori Hanai ◽  
Toshihide Maeda ◽  
Yui Ogiso ◽  
Kenji Imai ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Encephalopathy ◽  
Zinc Deficiency ◽  
Minimal Hepatic Encephalopathy ◽  
Overt Hepatic Encephalopathy

scholarly journals Role of probiotics in the treatment of minimal hepatic encephalopathy in patients with HBV-induced liver cirrhosis

2018 ◽  
Vol 46 (9) ◽  
pp. 3596-3604 ◽  
Author(s):  
Xiaoxue Xia ◽  
Jiang Chen ◽  
Jiayun Xia ◽  
Bin Wang ◽  
Hua Liu ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Encephalopathy ◽  
Minimal Hepatic Encephalopathy ◽  
Treated Group ◽  
Mucosal Barrier ◽  
Overt Hepatic Encephalopathy ◽  
Probiotic Treatment ◽  
B Virus ◽  
Number Connection Test

Objective This study was performed to investigate the role of probiotics ( Clostridium butyricum combined with Bifidobacterium infantis) in the treatment of minimal hepatic encephalopathy (MHE) in patients with hepatitis B virus (HBV)-induced liver cirrhosis. Methods Sixty-seven consecutive patients with HBV-induced cirrhosis without overt hepatic encephalopathy were screened using the number connection test and digit symbol test. The patients were randomized to receive probiotics (n = 30) or no probiotics (n = 37) for 3 months. At the end of the trial, changes in cognition, intestinal microbiota, venous ammonia, and intestinal mucosal barriers were analyzed using recommended systems biology techniques. Results The patients’ cognition was significantly improved after probiotic treatment. The predominant bacteria ( Clostridium cluster I and Bifidobacterium) were significantly enriched in the probiotics-treated group, while Enterococcus and Enterobacteriaceae were significantly decreased. Probiotic treatment was also associated with an obvious reduction in venous ammonia. Additionally, the parameters of the intestinal mucosal barrier were obviously improved after probiotic treatment, which might have contributed to the improved cognition and the decreased ammonia levels. Conclusion Treatment with probiotics containing C. butyricum and B. infantis represents a new adjuvant therapy for the management of MHE in patients with HBV-induced cirrhosis.

scholarly journals L-Carnitine for the Treatment of Overt Hepatic Encephalopathy in Patients with Advanced Liver Cirrhosis

2018 ◽  
Vol 64 (5) ◽  
pp. 321-328 ◽  
Author(s):  
Kazuto TAJIRI ◽  
Yuka FUTSUKAICHI ◽  
Saito KOBAYASHI ◽  
Satoshi YASUMURA ◽  
Terumi TAKAHARA ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Encephalopathy ◽  
Overt Hepatic Encephalopathy ◽  
Advanced Liver Cirrhosis

Sarcopenia predicts minimal hepatic encephalopathy in patients with liver cirrhosis

2017 ◽  
Vol 47 (13) ◽  
pp. 1359-1367 ◽  
Author(s):  
Tatsunori Hanai ◽  
Makoto Shiraki ◽  
Satoshi Watanabe ◽  
Takahiro Kochi ◽  
Kenji Imai ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Encephalopathy ◽  
Minimal Hepatic Encephalopathy

scholarly journals The Role of L-ornithine-L-aspartate in the Management of Minimal Hepatic Encephalopathy among Patients with Liver cirrhosis: a Systemic review and Meta-analysis

2018 ◽  
Vol 52 (1) ◽  
Author(s):  
Henry Winston C. Li ◽  
Maria Ana Louise M. Naidas ◽  
Karen Anjela M. Mondragon ◽  
Ruter M. Maralit
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Encephalopathy ◽  
Meta Analysis ◽  
Block Design ◽  
Cochrane Collaboration ◽  
Minimal Hepatic Encephalopathy ◽  
Systemic Review ◽  
Cochrane Library ◽  
P Value ◽  
Picture Completion

Objective. To evaluate the efficacy of L-ornithine-L-aspartate (LOLA) in improving minimal hepatic encephalopathy in adult patients with liver cirrhosis. Methods. A search in PubMed, Cochrane Library, Google Scholar, and Medline was made obtaining four qualified randomized controlled trials. Studies included adult cirrhotic patients with minimal hepatic encephalopathy measured by the number connection test (NCT-A, B), figure connection test (FCT-A, B), picture completion, block design test, and critical flicker frequency (CFF) testing with a cut-off score of <39Hz. Methodologic assessment of studies was performed using Cochrane Collaboration Risk of Bias Tool and Review Manager (RevMan) version 5.3 for statistical analysis. Results. Of the 29 studies identified, 4 fulfilled the inclusion criteria, which entailed analysis of 238 participants (LOLA: 116, Control: 122). Three out of the four studies were used in meta-analysis and one study was analyzed separately due to a difference in the neuropsychometric measure. The metaanalysis favored experimental group (LOLA), with a mean difference of 2.29 (95% CI 0.72 – 3.86), p-value = 0.004, and an I2 of 18%. Conclusion. LOLA provided great potential in managing encephalopathy since treating earlier related to better survival and prevention of disease progression. The results of our study supported such evidence and its use may be encouraged.

Overt hepatic encephalopathy precipitated by zinc deficiency

1991 ◽  
Vol 100 (4) ◽  
pp. 1114-1118 ◽  
Author(s):  
Carin C.D. Van Der Rijt ◽  
Solko W. Schalm ◽  
Han Schat ◽  
Karen Foeken ◽  
Gosse De Jong
Keyword(s):  
Hepatic Encephalopathy ◽  
Zinc Deficiency ◽  
Overt Hepatic Encephalopathy

scholarly journals Muscle Alterations Are Associated With Minimal and Overt Hepatic Encephalopathy in Patients With Liver Cirrhosis

Hepatology ◽  
2019 ◽  
Vol 70 (5) ◽  
pp. 1704-1713 ◽  
Author(s):  
Silvia Nardelli ◽  
Barbara Lattanzi ◽  
Manuela Merli ◽  
Alessio Farcomeni ◽  
Stefania Gioia ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Encephalopathy ◽  
Overt Hepatic Encephalopathy

scholarly journals Being an informal caregiver for a relative with liver cirrhosis and overt hepatic encephalopathy: a phenomenological study

2016 ◽  
Vol 25 (17-18) ◽  
pp. 2559-2568 ◽  
Author(s):  
Patrizia Künzler-Heule ◽  
Sonja Beckmann ◽  
Romy Mahrer-Imhof ◽  
David Semela ◽  
Daniela Händler-Schuster
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Encephalopathy ◽  
Phenomenological Study ◽  
Informal Caregiver ◽  
Overt Hepatic Encephalopathy
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