Risk factors and outcomes of hepatitis B virus reactivation in hepatitis B surface antigen negative patients with hematological malignancies

2015 ◽  
Vol 46 (7) ◽  
pp. 657-668 ◽  
Author(s):  
Ji Won Han ◽  
Hyun Yang ◽  
Hae Lim Lee ◽  
Si Hyun Bae ◽  
Jong Young Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hematological Malignancies ◽  
Hepatitis B Surface Antigen ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
B Virus

scholarly journals Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression

Hepatology ◽  
2015 ◽  
Vol 61 (3) ◽  
pp. 823-833 ◽  
Author(s):  
Romina Salpini ◽  
Luna Colagrossi ◽  
Maria Concetta Bellocchi ◽  
Matteo Surdo ◽  
Christina Becker ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Immune Escape ◽  
Hepatitis B Surface Antigen ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
Genetic Elements ◽  
B Virus

Hepatitis B virus reactivation during combined therapy with deferiprone and desferioxamine in a hepatitis B surface antigen thalassemic carrier

2008 ◽  
Vol 89 (2) ◽  
pp. 135-138 ◽  
Author(s):  
Paolo Ricchi ◽  
Patrizia Cinque ◽  
Alfonso Lanza Galeota ◽  
Tiziana Di Matola ◽  
Massimiliano Ammirabile ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Combined Therapy ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
B Virus

Increased risk of hepatitis B virus reactivation in systemic lupus erythematosus patients receiving immunosuppressants: a retrospective cohort study

Lupus ◽  
2017 ◽  
Vol 27 (1) ◽  
pp. 66-75 ◽  
Author(s):  
W T Lin ◽  
Y M Chen ◽  
D Y Chen ◽  
J L Lan ◽  
C S Chang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Lupus Erythematosus ◽  
Hepatitis B Surface Antigen ◽  
Virus Reactivation ◽  
Systemic Lupus ◽  
Hepatitis B Virus Reactivation ◽  
B Virus

Objective We aimed to investigate risk of hepatitis B virus reactivation in systemic lupus erythematosus patients with different hepatitis B virus infection statuses receiving immunosuppressive therapy. Methods We retrospectively analyzed systemic lupus erythematosus patients with positive hepatitis B surface antigen or anti-hepatitis B core IgG antibody who underwent immunosuppressive therapies from January 2001 to December 2012 at a medical center in Taiwan for evidence of hepatitis B virus reactivation. Results During this period, 906 out of 3125 patients who were diagnosed with systemic lupus erythematosus received screening tests for hepatitis B virus. Thirty-eight patients were identified as hepatitis B surface antigen-positive. Fifteen of 38 (39.5%) hepatitis B surface antigen-positive patients developed hepatitis B virus reactivation, and 53.3% of these patients experienced severe hepatitis flare. Three of 157 hepatitis B surface antigen-negative/anti-hepatitis B core IgG antibody-positive patients (1.9%) experienced hepatitis B surface antigen seroreversion after immunosuppressive therapy. Five patients received prophylactic or preemptive antiviral therapy and none of them developed hepatitis B virus flares. A daily dose of prednisolone greater than 5 mg was a risk factor for hepatitis B reactivation by multivariate logistic analysis. Conclusions The risk of hepatitis B virus reactivation is high in lupus patients receiving immunosuppressive therapy. Antiviral prophylaxis or preemption can effectively reduce the incidence of hepatitis B virus reactivation in lupus patients.

scholarly journals Prevalence and risk factors of hepatitis B virus transmission among children in Enugu, Nigeria

1970 ◽  
Vol 42 (3) ◽  
pp. 199-203
Author(s):  
ND Uleanya ◽  
EO Obidike
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Virus Transmission ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Cross Sectional ◽  
B Virus

Background: Hepatitis B Virus (HBV) infection has reached pandemic proportions all over the world with areas of highest prevalence being the sub- Saharan Africa and Southeast Asia. Most deaths related to HBV are due to complications from chronic infection. Acquisition of infection at a younger age is the most important predictor of chronicity. Eradication of HBV is an important but difficult tasks facing public health. HB immunization is the single most important factor in hepatitis B control and was commenced in 2004 in Nigeria.Objectives: To determine the prevalence of Hepatitis B surface antigen (HBsAg) among children in the era of HB immunization, the risk factors of transmission and knowledge of mothers about their HB status.Methods: A cross sectional study carried out on one hundred and forty children aged 18 months to 15 years at the children outpatient clinic (CHOP) of the University of Nigeria Teaching Hospital, Ituku. Hepatitis B surface antigen (HBsAg) was determined using Determine Test Kits and a structured interviewer administered questionnaire administered.Results: Six were positive for HBsAg, giving a prevalence rate of 4.3%. HBsAg was least prevalent among children 1-5 years (2%). None of the children ≤ 5 years who received HB vaccination was positive for HBsAg though one child > 5 years who received the vaccine was positive. Sharing of toothbrushes among siblings was found to be a significantly associated risk factor. Only 6.4% of mothers knew their hepatitis B status.Conclusion: There is a gradual fall in the prevalence of HBsAg in our environment due to HB immunization. Sharing of toothbrushes may be a potent means of transmission of HBV infection.Keywords: HBV, Prevalence, Children, Transmission, HB immunization

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