Helicobacter pylori eradication with bismuth quadruple therapy leads to dysbiosis of gut microbiota with an increased relative abundance of Proteobacteria and decreased relative abundances of Bacteroidetes and Actinobacteria

Helicobacter ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. e12498 ◽  
Author(s):  
Ping-I Hsu ◽  
Chao-Yu Pan ◽  
John Y. Kao ◽  
Feng-Woei Tsay ◽  
Nan-Jing Peng ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gut Microbiota ◽  
Relative Abundance ◽  
Helicobacter Pylori Eradication ◽  
Quadruple Therapy ◽  
Relative Abundances

EFFICACY OF MODIFIED BISMUTH QUADRUPLE THERAPY (RBMA) AS FIRST-LINE THERAPY FOR ERADICATION OF HELICOBACTER PYLORI IN PATIENTS WITH CHRONIC GASTRITIS

2019 ◽  
pp. 28-32
Author(s):  
Van Huy Tran
Keyword(s):  
Helicobacter Pylori ◽  
Adverse Effects ◽  
Chronic Gastritis ◽  
Eradication Rate ◽  
High Rate ◽  
First Line ◽  
Helicobacter Pylori Eradication ◽  
Quadruple Therapy ◽  
First Line Therapy ◽  
Line Therapy

Background and aims: Efficacy with substitution of tetracycline with amoxicillin, an antibiotics having a very low resistance rate and a high tolerability, in bismuth quadruple therapy (BQT) have not been studied in Vietnam. Our study aimed to evaluate the efficacy and tolerability of modified BQT vs. standard BQT for first-line Helicobacter pylori eradication. Patients and methods: This is a randomized, prospective study. 120 patients with H.pylori positive-chronic gastritis were randomly divided into two groups. The RBMA group containing rabeprazole 20 mg, bismuth subsalicylic 524mg, metronidazole 500mg, amoxicillin 1000mg, all 2 times a day, for 14 days. The RBMT group received rabeprazole, bismuth subsalicylic, metronidazole and tetracycline. Evaluation for compliance and drug-related side effects were evaluated at the end of two weeks. 4-6 weeks after the end of treatment, the H.pylori eradication rate was determined by the C13urease breath test. Results: Eradication rate was not statistically significative different between the RBMA and the RBMT: 91.2%; 95% confidence interval, 78.2% - 96.7%) vs. 90%; 95% CI, 81.6% - 96.3%) by per-protocol analysis (p = 0.42) and 86.7% (95%CI, 75.84% - 93.09%) vs. 75% (95%CI, 62.1% - 85.3%) by intention-to-treat analysis (ITT, p = 0.06). Adverse effects were significant higher in the RBMT group than in the RBMA group (48.3% vs. 26.7%; p = 0.071) and rate of good compliance was significantly higher in RBMA group than in RBMT group (p < 0.05). Conclusion: The modified BQT including rabeprazole, bismuth, metronidazole and amoxicillin achieved a fairly high rate of H.pylori infection eradication with a higher compliance and lower rate of adverse effects compared to the BQT in patients with chronic gastritis. Further studies need to conduct to confirm this new regimens as a first-line therapy in our country. Key words: Modified bismuth quadruple therapy, BQT, Helicobacter pylori eradication

scholarly journals High dose dual therapy versus bismuth quadruple therapy for Helicobacter pylori eradication treatment

Medicine ◽  
2019 ◽  
Vol 98 (7) ◽  
pp. e14396 ◽  
Author(s):  
Xue Yang ◽  
Jin-Xia Wang ◽  
Sheng-Xi Han ◽  
Cai-Ping Gao
Keyword(s):  
Helicobacter Pylori ◽  
Dual Therapy ◽  
High Dose ◽  
Helicobacter Pylori Eradication ◽  
Quadruple Therapy

Tu1350 Helicobacter pylori Eradication Rates and Related Factors by Second-Line Bismuth-Based Quadruple Therapy

2016 ◽  
Vol 150 (4) ◽  
pp. S881 ◽  
Author(s):  
Sung Eun Kim ◽  
Moo In Park ◽  
Seun Ja Park ◽  
Won Moon ◽  
Jun Yeob Lee ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Second Line ◽  
Related Factors ◽  
Helicobacter Pylori Eradication ◽  
Quadruple Therapy

Second-line Helicobacter pylori Eradication: A Randomized Comparison of 1-week or 2-week Bismuth-containing Quadruple Therapy

Helicobacter ◽  
2011 ◽  
Vol 16 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Jun-Won Chung ◽  
Jeong Hoon Lee ◽  
Hwoon-Yong Jung ◽  
Sung-Cheol Yun ◽  
Tae-Hoon Oh ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Second Line ◽  
Helicobacter Pylori Eradication ◽  
Quadruple Therapy
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