scholarly journals The Efficacy of Berberine-Containing Quadruple Therapy on Helicobacter Pylori Eradication in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

2020 ◽  
Vol 10 ◽  
Author(s):  
Qian Hu ◽  
Ze Peng ◽  
Lingli Li ◽  
Xin Zou ◽  
Lijun Xu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Helicobacter Pylori ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Helicobacter Pylori Eradication ◽  
Quadruple Therapy

scholarly journals Análise da Revisão Cochrane: Erradicação da Helicobacter pylori na Prevenção do Cancro Gástrico. Cochrane Database Syst Rev. 2015;7:CD005583.

2015 ◽  
Vol 28 (6) ◽  
pp. 684
Author(s):  
Diogo Libânio ◽  
Luís Filipe Azevedo
Keyword(s):  
Gastric Cancer ◽  
Clinical Trials ◽  
Helicobacter Pylori ◽  
Gastric Adenocarcinoma ◽  
Cancer Incidence ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Helicobacter Pylori Eradication ◽  
Cochrane Database ◽  
Primary Prevention Strategy

Helicobacter pylori infection is a risk factor for gastric adenocarcinoma. Identification of individuals with this infection and its eradication may be considered as a primary prevention strategy to reduce the incidence of gastric adenocarcinoma; however, the magnitude of benefit and the effectiveness of this strategy are still unclear. A systematic review and meta-analysis of randomized clinical trials was conducted comparing the incidence of gastric adenocarcinoma in infected individuals submitted to Helicobacter pylori eradication and individuals not submitted to this therapy. The results of the six included randomized clinical trials (all conducted in countries with<br />high gastric cancer incidence) suggest that Helicobacter pylori eradication is associated with a relative risk reduction of 34% in gastric cancer incidence. However, generalization of the results to countries with lower gastric cancer incidence should be cautious and the cost-effectiveness of this strategy in this context remains uncertain.

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