The associations between orthostatic blood pressure changes and extracellular volume in hemodialysis patients

2021 ◽  
Author(s):  
Haekyung Jeon‐Slaughter ◽  
Lucile Parker Gregg ◽  
Michael Concepcion ◽  
Swati Lederer ◽  
Jeffrey Penfield ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Extracellular Volume ◽  
Hemodialysis Patients ◽  
Orthostatic Blood Pressure ◽  
Pressure Changes

scholarly journals Clinical Epidemiology of Systolic and Diastolic Orthostatic Hypotension in Patients on Peritoneal Dialysis

2021 ◽  
Vol 10 (14) ◽  
pp. 3075
Author(s):  
Claudia Torino ◽  
Rocco Tripepi ◽  
Maria Carmela Versace ◽  
Antonio Vilasi ◽  
Giovanni Tripepi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Peritoneal Dialysis ◽  
Orthostatic Hypotension ◽  
Clinical Epidemiology ◽  
Hemodialysis Patients ◽  
Excess Death ◽  
Death Risk ◽  
Standardized Protocol ◽  
Pressure Changes ◽  
The Impact

Blood pressure changes upon standing reflect a hemodynamic response, which depends on the baroreflex system and euvolemia. Dysautonomia and fluctuations in blood volume are hallmarks in kidney failure requiring replacement therapy. Orthostatic hypotension has been associated with mortality in hemodialysis patients, but neither this relationship nor the impact of changes in blood pressure has been tested in patients on peritoneal dialysis. We investigated both these relationships in a cohort of 137 PD patients. The response to orthostasis was assessed according to a standardized protocol. Twenty-five patients (18%) had systolic orthostatic hypotension, and 17 patients (12%) had diastolic hypotension. The magnitude of systolic and diastolic BP changes was inversely related to the value of the corresponding supine BP component (r = −0.16, p = 0.056 (systolic) and r = −0.25, p = 0.003 (diastolic), respectively). Orthostatic changes in diastolic, but not in systolic, BP were linearly related to the death risk (HR (1 mmHg reduction): 1.04, 95% CI 1.01–1.07, p = 0.006), and this was also true for CV death (HR: 1.08, 95% CI 1.03–1.12, p = 0.001). The strength of this association was not affected by further data adjustment (p ≤ 0.05). These findings suggest that independent of the formal diagnosis of orthostatic hypotension, even minor orthostatic reductions in diastolic BP bear an excess death risk in this population.

Orthostatic blood pressure changes and physical, functional and cognitive performance: the MELoR study

2019 ◽  
Vol 30 (2) ◽  
pp. 129-137 ◽  
Author(s):  
Nor Izzati Saedon ◽  
◽  
James Frith ◽  
Choon-Hian Goh ◽  
Wan Azman Wan Ahmad ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cognitive Performance ◽  
Orthostatic Blood Pressure ◽  
Pressure Changes

Orthostatic Blood Pressure Changes on Prolonged Standing in Elderly Hospital In-Patients

1997 ◽  
Vol 6 (6) ◽  
pp. 343-348 ◽  
Author(s):  
Martin Fotherby ◽  
Pervaiz Iqbal ◽  
John Potter
Keyword(s):  
Blood Pressure ◽  
Prolonged Standing ◽  
Orthostatic Blood Pressure ◽  
Pressure Changes
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