scholarly journals Left ventricular diastolic dysfunction is directly associated with cerebral white matter lesions in elderly patients

2015 ◽  
Vol 15 ◽  
pp. 81-82
Author(s):  
Atsuya Shimizu ◽  
Manabu Kokubo ◽  
Toko Mitsui ◽  
Motohiro Miyagi ◽  
Kenichiro Nomoto ◽  
...  
Keyword(s):  
White Matter ◽  
Elderly Patients ◽  
Diastolic Dysfunction ◽  
White Matter Lesions ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions ◽  
Ventricular Diastolic Dysfunction

scholarly journals Connecting Cerebral White Matter Lesions and Hypertensive Target Organ Damage

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Cristina Sierra ◽  
Alfons López-Soto ◽  
Antonio Coca
Keyword(s):  
Risk Factor ◽  
White Matter ◽  
Brain Damage ◽  
White Matter Lesions ◽  
Organ Damage ◽  
Left Ventricular ◽  
Cerebral White Matter ◽  
Chronic Hypertension ◽  
Cerebral White Matter Lesions ◽  
The Brain

Chronic hypertension leads to concomitant remodeling of the cardiac and vascular systems and various organs, especially the brain, kidney, and retina. The brain is an early target of organ damage due to high blood pressure, which is the major modifiable risk factor for stroke and small vessel disease. Stroke is the second leading cause of death and the number one cause of disability worldwide and over 80% of strokes occur in the elderly. Preclinical hypertensive lesions in most target organs are clearly identified: left ventricular hypertrophy for the heart, microalbuminuria for the kidney, fundus abnormalities for the eye, and intima-media thickness and pulse wave velocity for the vessels. However, early hypertensive brain damage is not fully studied due to difficulties in access and the expense of techniques. After age, hypertension is the most-important risk factor for cerebral white matter lesions, which are an important prognostic factor for stroke, cognitive impairment, dementia, and death. Studies have shown an association between white matter lesions and a number of extracranial systems affected by high BP and also suggest that correct antihypertensive treatment could slow white matter lesions progression. There is strong evidence that cerebral white matter lesions in hypertensive patients should be considered a silent early marker of brain damage.

scholarly journals The relationship between left ventricular diastolic function and the autonomic nervous function in elderly patients with mild-to-moderate essential hypertension

2018 ◽  
Vol 5 (3) ◽  
pp. 8
Author(s):  
Qunwei Liu ◽  
Xin Lin ◽  
Lei Dong ◽  
Limin Han ◽  
Feng Chang
Keyword(s):  
Essential Hypertension ◽  
Elderly Patients ◽  
Diastolic Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Moderate Essential Hypertension ◽  
Autonomic Nervous Function ◽  
Autonomic Nervous ◽  
Ventricular Diastolic Dysfunction ◽  
Nervous Function

Objective: To investigate the relationship between left ventricular diastolic function (LVDF) and autonomic nervous function in elderly patients with mild-to-moderate essential hypertension.Design: A total of 146 elderly patients with mild-to-moderate essential hypertension were enrolled in our hospital from January, 2015 to October, 2017. Blood pressure was recorded, and biochemical indexes and the N-terminal pro-brain natriuretic preptide (NT-proBNP) were investigated. 2-dimensional echocadiolography was used to measure the parameters of LVDF. Based on the classification standard of LVDF, all subjects were divided into two groups: normal LVDF group (n = 72), left ventricular diastolic dysfunction group (n = 74). At the same time, the dynamic electrocardiogram were investigated for all subjects to monitor the indexes of time on heart rate variability (HRV).Results: (1) The level of NT-proBNP, left ventricular mass index (LVMI), interventricular septal thickness (IVST) and LVPWT increased significantly (p < .05 for all), while the level of PNN50, rMSSD, SDANN and SDNN decreased significantly (p < .05 for all) in left ventricular diastolic dysfunction group (abnormal LVDF group) compared with that in normal LVDF group (normal LVDF group); (2) The partial correlation analysis showed that rMSSD, PNN50 and triangle index were negatively correlated with peak A (r = -0.208, -0.219, -0.211, p < .05 for all), and positive correlated with the ratio of peak E to peak A (E/A) (r = 0.179, 0.184, 0.181, p < .05); SDNN were negatively correlated with NT-proBNP and E/E’ (r = -0.183, -0.181, p < .05 for all), positive correlated with E’ (r = 0.178, p < .05); (3) Multiple stepwise regression analysis showed that peak A and E/A were independent influencing factors for PNN50 (β = -0.261, p = .004; β = 0.179, p = .016); E/E’ and NT-proBNP were independent influencing factor for SDNN (β = -0.163, p = .018; β = -0.172, p = .022).Conclusions: Left ventricular diastolic dysfunction is closely related to impaired autonomic nervous function in elderly patients with mild-to-moderate essential hypertension.  

VITAMIN D DEFICIENCY IN ELDERLY WITH ARTERIAL HYPERTENSION AND LEFT VENTRICULAR DIASTOLIC DYSFUNCTION

2021 ◽  
pp. 566-571
Author(s):  
О.А. Осипова ◽  
Е.В. Гостева ◽  
Ю.В. Татаринцева ◽  
Н.И. Жернакова ◽  
Е.В. Екушева ◽  
...  
Keyword(s):  
Vitamin D ◽  
Elderly Patients ◽  
Arterial Hypertension ◽  
Diastolic Dysfunction ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Serum Vitamin D ◽  
Ventricular Diastolic Dysfunction

Цель работы - оценка связи дефицита витамина D в сыворотке крови и риска диастолической дисфункции у пожилых пациентов с артериальной гипертензией (АГ). В исследование включены 162 больных пожилого возраста (средний возраст - 65,4±5,2 года) с АГ: 1-ю группу составили 67 пациентов с АГ без дефицита витамина D; 2-ю - 95 пациентов с АГ при наличии дефицита. Выявлено, что при дефиците витамина D в сыворотке крови больные были достоверно старше (Δ7,3 %, р<0,05), имели более высокий ИМТ (Δ9,6 %, р<0,05), меньшую дистанцию при тесте шестиминутной ходьбы (Δ10,4 %, р<0,05), чаще (72,6 %) имели диастолическую дисфункцию ЛЖ (ДД ЛЖ). Больные АГ с ДД ЛЖ при дефиците витамина D в сыворотке имели худший метаболический профиль - у них установлены более высокие значения общего холестерина (Δ15,7 %, р<0,05), триглицеридов (Δ15,2 %, р<0,05), индекса НОМА-IR (Δ12 %, р<0,05) и более низкие значения ЛПВП (Δ11,9 %, р<0,05). У больных АГ с ДД ЛЖ при дефиците витамина D качество жизни ниже, чем у больных с адекватным его уровнем. Больные пожилого возраста с АГ имели незначительную разницу по частоте встречаемости ДД ЛЖ между изучаемыми группами с разным статусом витамина D. Тем не менее, пожилые больные АГ при дефиците витамина D в сыворотке имели более выраженные нарушения диастолической дисфункции ЛЖ, липидного и углеводного обмена. Качество жизни по опроснику SF-36 у пожилых больных АГ при дефиците витамина D в сыворотке крови было достоверно ниже, чем в группе с адекватным его содержанием. The aim of the study was to evaluate the relationship between serum vitamin D deficiency and the risk of diastolic dysfunction in elderly patients with arterial hypertension. The study included 162 elderly patients (mean age 65,4±5,2 years) with arterial hypertension. The first group consisted of 67 patients with hypertension without vitamin D deficiency, the second-95 patients with hypertension with deficiency. It was revealed that the patients with vitamin D deficiency in the blood serum were significantly older (Δ7,3 %, p<0,05), had a higher body mass index (Δ9,6 %, p<0,05), a shorter distance in the 6-minute walk test (Δ10,4 %, p<0,05), and more often (72,6 %) had left ventricular diastolic dysfunction (LV DD). Patients with hypertension with LV DD in the presence of vitamin D deficiency in serum had a worse metabolic profile - they had higher values of total cholesterol (Δ15,7 %, p<0,05), triglycerides (Δ15,2 %, p<0,05), the НOMA-IR index (Δ12 %, p<0,05) and lower HDL values (Δ11,9 %, p<0,05). In patients with hypertension with LV DD in the presence of vitamin D deficiency, the quality of life is lower than in patients with adequate levels of it. Conclusions. Elderly patients with hypertension had a slight difference in the incidence of LV DD between the study groups with different vitamin D status. However, elderly patients with hypertension with serum vitamin D deficiency had more pronounced disorders of LV diastolic dysfunction, lipid and carbohydrate metabolism. The quality of life according to the SF-36 questionnaire in elderly patients with hypertension with vitamin D deficiency in the blood serum was significantly lower than in the group with adequate vitamin D content.

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