Prodromal dementia with Lewy bodies

2015 ◽  
Vol 15 (7) ◽  
pp. 817-826 ◽  
Author(s):  
Hiroshige Fujishiro ◽  
Shinichiro Nakamura ◽  
Kiyoshi Sato ◽  
Eizo Iseki
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Prodromal Dementia

Prodromal Dementia With Lewy Bodies: Evolution of Symptoms and Predictors of Dementia Onset

2021 ◽  
pp. 089198872110235
Author(s):  
Kathryn A. Wyman-Chick ◽  
Lauren R. O’Keefe ◽  
Daniel Weintraub ◽  
Melissa J. Armstrong ◽  
Michael Rosenbloom ◽  
...  
Keyword(s):  
Clinical Features ◽  
Dementia With Lewy Bodies ◽  
Clinical Symptoms ◽  
Neuropsychiatric Symptoms ◽  
Lewy Bodies ◽  
Rem Sleep Behavior Disorder ◽  
Data Set ◽  
Wide Range ◽  
Prodromal Dementia ◽  
Dementia Onset

Background: Research criteria for prodromal dementia with Lewy bodies (DLB) were published in 2020, but little is known regarding prodromal DLB in clinical settings. Methods: We identified non-demented participants without neurodegenerative disease from the National Alzheimer’s Coordinating Center Uniform Data Set who converted to DLB at a subsequent visit. Prevalence of neuropsychiatric and motor symptoms were examined up to 5 years prior to DLB diagnosis. Results: The sample included 116 participants clinically diagnosed with DLB and 348 age and sex-matched (1:3) Healthy Controls. Motor slowing was present in approximately 70% of participants 3 years prior to DLB diagnosis. In the prodromal phase, 50% of DLB participants demonstrated gait disorder, 70% had rigidity, 20% endorsed visual hallucinations, and over 50% of participants endorsed REM sleep behavior disorder. Apathy, depression, and anxiety were common prodromal neuropsychiatric symptoms. The presence of 1+ core clinical features of DLB in combination with apathy, depression, or anxiety resulted in the greatest AUC (0.815; 95% CI: 0.767, 0.865) for distinguishing HC from prodromal DLB 1 year prior to diagnosis. The presence of 2+ core clinical features was also accurate in differentiating between groups (AUC = 0.806; 95% CI: 0.756, 0.855). Conclusion: A wide range of motor, neuropsychiatric and other core clinical symptoms are common in prodromal DLB. A combination of core clinical features, neuropsychiatric symptoms and cognitive impairment can accurately differentiate DLB from normal aging prior to dementia onset.

P1-180: Prodromal and Non-Prodromal Dementia with Lewy Bodies and Alzheimer's Disease: A Multimodal Mri Approach

2016 ◽  
Vol 12 ◽  
pp. P473-P473
Author(s):  
Frederic Blanc ◽  
Daniel Roquet ◽  
Vincent Noblet ◽  
Benjamin Cretin ◽  
Julien Lamy ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Multimodal Mri ◽  
Prodromal Dementia

O5-03-03: PREVALENCE OF NEUROPSYCHIATRIC AND MOTOR SYMPTOMS IN PRODROMAL DEMENTIA WITH LEWY BODIES

2006 ◽  
Vol 14 (7S_Part_31) ◽  
pp. P1645-P1646
Author(s):  
Kathryn A. Wyman-Chick ◽  
Lauren O. Erickson ◽  
Michael H. Rosenbloom ◽  
Terry R. Barclay ◽  
Julia C. Johnson ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Motor Symptoms ◽  
Prodromal Dementia

Imaging in prodromal dementia with Lewy bodies: Where do we stand?

2019 ◽  
Vol 34 (5) ◽  
pp. 635-646 ◽  
Author(s):  
Rory Durcan ◽  
Paul Donaghy ◽  
Curtis Osborne ◽  
John‐Paul Taylor ◽  
Alan J. Thomas
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Prodromal Dementia

scholarly journals Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies

2018 ◽  
Vol 49 (3) ◽  
pp. 396-402 ◽  
Author(s):  
Alan J. Thomas ◽  
Paul Donaghy ◽  
Gemma Roberts ◽  
Sean J. Colloby ◽  
Nicky A. Barnett ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Lewy Body ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Lewy Body Disease ◽  
High Specificity ◽  
Diagnostic Confidence ◽  
Neuropsychological Assessments ◽  
Diagnostic Symptoms ◽  
Prodromal Dementia

AbstractBackgroundDopaminergic imaging has high diagnostic accuracy for dementia with Lewy bodies (DLB) at the dementia stage. We report the first investigation of dopaminergic imaging at the prodromal stage.MethodsWe recruited 75 patients over 60 with mild cognitive impairment (MCI), 33 with probable MCI with Lewy body disease (MCI-LB), 15 with possible MCI-LB and 27 with MCI with Alzheimer's disease. All underwent detailed clinical, neurological and neuropsychological assessments and FP-CIT [123I-N-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)] dopaminergic imaging. FP-CIT scans were blindly rated by a consensus panel and classified as normal or abnormal.ResultsThe sensitivity of visually rated FP-CIT imaging to detect combined possible or probable MCI-LB was 54.2% [95% confidence interval (CI) 39.2–68.6], with a specificity of 89.0% (95% CI 70.8–97.6) and a likelihood ratio for MCI-LB of 4.9, indicating that FP-CIT may be a clinically important test in MCI where any characteristic symptoms of Lewy body (LB) disease are present. The sensitivity in probable MCI-LB was 61.0% (95% CI 42.5–77.4) and in possible MCI-LB was 40.0% (95% CI 16.4–67.7).ConclusionsDopaminergic imaging had high specificity at the pre-dementia stage and gave a clinically important increase in diagnostic confidence and so should be considered in all patients with MCI who have any of the diagnostic symptoms of DLB. As expected, the sensitivity was lower in MCI-LB than in established DLB, although over 50% still had an abnormal scan. Accurate diagnosis of LB disease is important to enable early optimal treatment for LB symptoms.

scholarly journals Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression

2020 ◽  
Vol 35 (5) ◽  
pp. 859-867 ◽  
Author(s):  
Marleen Beek ◽  
Inger Steenoven ◽  
Jessica J. Zande ◽  
Frederik Barkhof ◽  
Charlotte E. Teunissen ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Prodromal Dementia

Low-dose zolpidem-induced visual hallucinations in prodromal dementia with Lewy bodies

2021 ◽  
pp. 102908
Author(s):  
Ryota Kobayashi ◽  
Daichi Morioka ◽  
Akihito Suzuki ◽  
Shinobu Kawakatsu ◽  
Koichi Otani
Keyword(s):  
Dementia With Lewy Bodies ◽  
Low Dose ◽  
Lewy Bodies ◽  
Visual Hallucinations ◽  
Prodromal Dementia

scholarly journals Research criteria for the diagnosis of prodromal dementia with Lewy bodies

Neurology ◽  
2020 ◽  
Vol 94 (17) ◽  
pp. 743-755 ◽  
Author(s):  
Ian G. McKeith ◽  
Tanis J. Ferman ◽  
Alan J. Thomas ◽  
Frédéric Blanc ◽  
Bradley F. Boeve ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Criteria ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Sufficient Information ◽  
Evidence Based ◽  
Prodromal Phase ◽  
Research Criteria ◽  
Prodromal Dementia

The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-based recommendations for the recognition of DLB at a predementia, symptomatic stage. We propose operationalized diagnostic criteria for probable and possible mild cognitive impairment with Lewy bodies, which are intended for use in research settings pending validation for use in clinical practice. They are compatible with current criteria for other prodromal neurodegenerative disorders including Alzheimer and Parkinson disease. Although there is still insufficient evidence to propose formal criteria for delirium-onset and psychiatric-onset presentations of DLB, we feel that it is important to characterize them, raising the index of diagnostic suspicion and prioritizing them for further investigation.

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