Early diagnosis of prodromal dementia with Lewy bodies using clinical history of probable REM sleep behaviour disorder and cardiac 123 I‐MIBG scintigraphy in memory clinics

2021 ◽  
Author(s):  
Hiroshige Fujishiro ◽  
Kazumi Ota ◽  
Mayumi Yamagata ◽  
Tatsuya Ito ◽  
Sotaro Hieda ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Clinical History ◽  
Mibg Scintigraphy ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder ◽  
Memory Clinics ◽  
History Of ◽  
Prodromal Dementia

scholarly journals Tiapride for the Treatment of REM Sleep Behaviour Disorder in Dementia with Lewy Bodies: A Case Series

2019 ◽  
Vol 13 (1) ◽  
pp. 63-66
Author(s):  
Georg Adler ◽  
Angelika E. Mautes
Keyword(s):  
Rem Sleep ◽  
Dementia With Lewy Bodies ◽  
Case Series ◽  
Lewy Bodies ◽  
Dopamine Synthesis ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder ◽  
Presynaptic Dopamine Receptors ◽  
Low Dosage

Objective: REM sleep Behaviour Disorder (RBD) in Dementia with Lewy bodies (DLB) may be attributed to a decrease in dopaminergic neurotransmission. Thus, we studied the therapeutic efficacy of the pre and postsynaptic D2 and D3 receptor antagonist tiapride, which at a low dosage preferentially blocks presynaptic dopamine receptors and consequently leads to feedback activation of dopamine synthesis and to increased extracellular levels of dopamine. Methods: Six consecutive patients presenting at our memory clinic with RBD in DLB, in whom melatonin had been ineffective and clonazepam was found inappropriate for clinical reasons, were treated with triapride at dosages between 50 and 150 mg for twelve weeks. Results: Tiapride was well tolerated by all patients. Five of the six patients, reported was a decrease of the self-perceived frequency of bad dreams and the intensity and severity of motor and vocal enactments during sleep. In four of these six patients, this was also the case in the view of the patients’ bed partners. Conclusion: Tiapride may by an effective and well-tolerated treatment for RBD in patients with DLB.

scholarly journals Evolution of prodromal Parkinson’s disease and dementia with Lewy bodies: a prospective study

Brain ◽  
2019 ◽  
Vol 142 (7) ◽  
pp. 2051-2067 ◽  
Author(s):  
Seyed-Mohammad Fereshtehnejad ◽  
Chun Yao ◽  
Amelie Pelletier ◽  
Jacques Y Montplaisir ◽  
Jean-François Gagnon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rem Sleep ◽  
Colour Vision ◽  
Rating Scale ◽  
Lewy Bodies ◽  
Behaviour Disorder ◽  
Mixed Effect ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

Abstract Parkinson’s disease has a long prodromal stage with various subclinical motor and non-motor manifestations; however, their evolution in the years before Parkinson’s disease is diagnosed is unclear. We traced the evolution of early motor and non-motor manifestations of synucleinopathy from the stage of idiopathic rapid eye movement (REM) sleep behaviour disorder until defined neurodegenerative disease. During 2004–16, we recruited and then annually followed 154 polysomnography-proven patients with idiopathic REM sleep behaviour disorder, of whom 55 phenoconverted to defined parkinsonism or dementia. Longitudinal data on multiple prodromal features, including the Unified Parkinson’s Disease Rating Scale parts I–III, quantitative motor tests, olfaction, colour vision, cognition, and autonomic functions were gathered annually (average = five follow-up visits, range: 2–12 years). The same measures were also assessed in 102 age- and sex-matched healthy control subjects. By looking backward from the time of dementia or parkinsonism diagnosis, we examined trajectories of each prodromal feature using mixed effect models. Based on analysis, olfactory loss was first to develop, with predicted onset >20 years before phenoconversion. This was followed by impaired colour vision, constipation, and erectile dysfunction, starting 10–16 years prior to phenoconversion. At 7–9 years before phenoconversion, slight urinary dysfunction and subtle cognitive decline could be detected. Among motor symptoms altered handwriting, turning in bed, walking, salivation, speech, and facial expression began to be disrupted starting 7–11 years prior to parkinsonism diagnosis, but remained mild until soon before phenoconversion. Motor examination abnormalities began 5–7 years before phenoconversion, with the alternate tap test having the longest interval (8 years before phenoconversion). Among cardinal motor phenotypes, bradykinesia appeared first, ∼5–6 years prior to phenoconversion, followed by rigidity (Year −3) and tremor (Year −2). With direct prospective evaluation of an idiopathic REM sleep behaviour disorder cohort during phenoconversion, we documented an evolution of prodromal manifestations similar to that predicted by pathological staging models, with predicted prodromal intervals as long as 20 years.

scholarly journals Prodromal dementia with Lewy bodies

2014 ◽  
Vol 45 (2) ◽  
pp. 259-268 ◽  
Author(s):  
P. C. Donaghy ◽  
J. T. O'Brien ◽  
A. J. Thomas
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Disease Process ◽  
Original Data ◽  
Imaging Biomarkers ◽  
Therapeutic Approaches ◽  
Medline Search ◽  
Sleep Behaviour ◽  
Prodromal Alzheimer’S Disease ◽  
Prodromal Dementia

BackgroundThe clinical condition of dementia is now recognized as a diagnosis that can only be applied too late in the disease process to be useful for therapeutic approaches centring on disease modification. As a result, in recent years increasing attention has been given to mild cognitive impairment (MCI) and the diagnosis of prodromal dementia. This paper reviews the evidence for the clinical presentation of prodromal dementia with Lewy bodies (DLB).MethodA Medline search was carried out to identify articles with original data on the prodromal presentation of DLB.ResultsIn MCI cohorts that progress to dementia, the proportion diagnosed with DLB is similar to that reported in dementia cohorts. Prodromal DLB may present as any MCI subtype, although visuospatial and executive domains may be most commonly affected. Rapid eye movement (REM) sleep behaviour disorder (RBD), autonomic symptoms, hyposmia, hallucinations and motor symptoms seem to be more common in prodromal DLB than in prodromal Alzheimer's disease (AD). Some of these symptoms can precede the diagnosis of DLB by several years. There has been little research into the use of biomarkers in prodromal DLB, although in RBD cohorts, clinical and imaging biomarkers have been associated with the development of DLB.ConclusionsThe evidence available suggests that prodromal DLB may be differentiated from other dementia prodromes in most cases. Further research is needed to confirm this, and to assess the utility of biomarkers such as 123I-FP-CIT and 123I-MIBG imaging.

Prodromal Dementia With Lewy Bodies: Evolution of Symptoms and Predictors of Dementia Onset

2021 ◽  
pp. 089198872110235
Author(s):  
Kathryn A. Wyman-Chick ◽  
Lauren R. O’Keefe ◽  
Daniel Weintraub ◽  
Melissa J. Armstrong ◽  
Michael Rosenbloom ◽  
...  
Keyword(s):  
Clinical Features ◽  
Dementia With Lewy Bodies ◽  
Clinical Symptoms ◽  
Neuropsychiatric Symptoms ◽  
Lewy Bodies ◽  
Rem Sleep Behavior Disorder ◽  
Data Set ◽  
Wide Range ◽  
Prodromal Dementia ◽  
Dementia Onset

Background: Research criteria for prodromal dementia with Lewy bodies (DLB) were published in 2020, but little is known regarding prodromal DLB in clinical settings. Methods: We identified non-demented participants without neurodegenerative disease from the National Alzheimer’s Coordinating Center Uniform Data Set who converted to DLB at a subsequent visit. Prevalence of neuropsychiatric and motor symptoms were examined up to 5 years prior to DLB diagnosis. Results: The sample included 116 participants clinically diagnosed with DLB and 348 age and sex-matched (1:3) Healthy Controls. Motor slowing was present in approximately 70% of participants 3 years prior to DLB diagnosis. In the prodromal phase, 50% of DLB participants demonstrated gait disorder, 70% had rigidity, 20% endorsed visual hallucinations, and over 50% of participants endorsed REM sleep behavior disorder. Apathy, depression, and anxiety were common prodromal neuropsychiatric symptoms. The presence of 1+ core clinical features of DLB in combination with apathy, depression, or anxiety resulted in the greatest AUC (0.815; 95% CI: 0.767, 0.865) for distinguishing HC from prodromal DLB 1 year prior to diagnosis. The presence of 2+ core clinical features was also accurate in differentiating between groups (AUC = 0.806; 95% CI: 0.756, 0.855). Conclusion: A wide range of motor, neuropsychiatric and other core clinical symptoms are common in prodromal DLB. A combination of core clinical features, neuropsychiatric symptoms and cognitive impairment can accurately differentiate DLB from normal aging prior to dementia onset.

Cognitive performance in REM sleep behaviour disorder: a possible early marker of neurodegenerative disease?

2008 ◽  
Vol 9 (4) ◽  
pp. 343-351 ◽  
Author(s):  
Michele Terzaghi ◽  
Elena Sinforiani ◽  
Chiara Zucchella ◽  
Elena Zambrelli ◽  
Chiara Pasotti ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Cognitive Performance ◽  
Rem Sleep ◽  
Behaviour Disorder ◽  
Early Marker ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

scholarly journals REM Sleep Behaviour Disorder in a Child with Tourette's Syndrome

2004 ◽  
Vol 31 (4) ◽  
pp. 572-575 ◽  
Author(s):  
Nikola N. Trajanovic ◽  
Inna Voloh ◽  
Colin M. Shapiro ◽  
Paul Sandor
Keyword(s):  
Eye Movement ◽  
Single Case ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Single Case Study ◽  
Rapid Eye Movement Sleep ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

Purpose:To describe an association of Tourette's syndrome with rapid eye movement sleep behaviour disorder (RBD) in a prepubescent boy.Methods:A four year longitudinal single-case study.Results:The co-existence of Tourette's syndrome and RBD was confirmed after polysomnographic studies using the standard criteria. The authors propose possible overlap in the pathophysiological mechanisms underlying the two disorders.

REM sleep Behaviour Disorder

2016 ◽  
Vol 22 ◽  
pp. S69-S72 ◽  
Author(s):  
Luigi Ferini-Strambi ◽  
Fabrizio Rinaldi ◽  
Enrico Giora ◽  
Sara Marelli ◽  
Andrea Galbiati
Keyword(s):  
Rem Sleep ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder
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