scholarly journals Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression

2017 ◽  
Vol 16 (7) ◽  
pp. 699-708 ◽  
Author(s):  
H. Chen ◽  
D. He ◽  
A. W. Lasek
Keyword(s):  
Gene Expression ◽  
Ventral Tegmental Area ◽  
Ethanol Intake ◽  
Ventral Tegmental ◽  
Ccl2 Gene

scholarly journals Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area

2021 ◽  
Author(s):  
Rianne R. Campbell ◽  
Siwei Chen ◽  
Joy H. Beardwood ◽  
Alberto J. López ◽  
Lilyana V. Pham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ventral Tegmental Area ◽  
Home Cage ◽  
Expression Patterns ◽  
Energy Regulation ◽  
Biological Processes ◽  
Cocaine Exposure ◽  
Self Administration ◽  
Drug Reinforcement ◽  
Ventral Tegmental

AbstractDuring the initial stages of drug use, cocaine-induced neuroadaptations within the ventral tegmental area (VTA) are critical for drug-associated cue learning and drug reinforcement processes. These neuroadaptations occur, in part, from alterations to the transcriptome. Although cocaine-induced transcriptional mechanisms within the VTA have been examined, various regimens and paradigms have been employed to examine candidate target genes. In order to identify key genes and biological processes regulating cocaine-induced processes, we employed genome-wide RNA-sequencing to analyze transcriptional profiles within the VTA from male mice that underwent one of four commonly used paradigms: acute home cage injections of cocaine, chronic home cage injections of cocaine, cocaine-conditioning, or intravenous-self administration of cocaine. We found that cocaine alters distinct sets of VTA genes within each exposure paradigm. Using behavioral measures from cocaine self-administering mice, we also found several genes whose expression patterns corelate with cocaine intake. In addition to overall gene expression levels, we identified several predicted upstream regulators of cocaine-induced transcription shared across all paradigms. Although distinct gene sets were altered across cocaine exposure paradigms, we found, from Gene Ontology (GO) term analysis, that biological processes important for energy regulation and synaptic plasticity were affected across all cocaine paradigms. Coexpression analysis also identified gene networks that are altered by cocaine. These data indicate that cocaine alters networks enriched with glial cell markers of the VTA that are involved in gene regulation and synaptic processes. Our analyses demonstrate that transcriptional changes within the VTA depend on the route, dose and context of cocaine exposure, and highlight several biological processes affected by cocaine. Overall, these findings provide a unique resource of gene expression data for future studies examining novel cocaine gene targets that regulate drug-associated behaviors.

Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats

2014 ◽  
Vol 20 (2) ◽  
pp. 336-344 ◽  
Author(s):  
Eduardo Karahanian ◽  
Mario Rivera-Meza ◽  
Lutske Tampier ◽  
María Elena Quintanilla ◽  
Mario Herrera-Marschitz ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Aldehyde Dehydrogenase ◽  
Lentiviral Vector ◽  
Ethanol Intake ◽  
Aldehyde Dehydrogenase 2 ◽  
Ventral Tegmental

scholarly journals Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats

Alcohol ◽  
2013 ◽  
Vol 47 (5) ◽  
pp. 367-380 ◽  
Author(s):  
William J. McBride ◽  
Mark W. Kimpel ◽  
Jeanette N. McClintick ◽  
Zheng-Ming Ding ◽  
Sheketha R. Hauser ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ventral Tegmental Area ◽  
Alcohol Drinking ◽  
Ventral Tegmental

scholarly journals Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

2015 ◽  
Vol 18 (3) ◽  
pp. 415-422 ◽  
Author(s):  
Ja Wook Koo ◽  
Michelle S Mazei-Robison ◽  
Quincey LaPlant ◽  
Gabor Egervari ◽  
Kevin M Braunscheidel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ventral Tegmental Area ◽  
Bdnf Gene ◽  
Ventral Tegmental

Blocking GABA A receptors in the anterior ventral tegmental area attenuates ethanol intake of the alcohol-preferring P rat

1998 ◽  
Vol 139 (1-2) ◽  
pp. 108-116 ◽  
Author(s):  
K. L. Nowak ◽  
W. J. McBride ◽  
L. Lumeng ◽  
T.-K. Li ◽  
J. M. Murphy
Keyword(s):  
Ventral Tegmental Area ◽  
Ethanol Intake ◽  
Gaba A ◽  
Ventral Tegmental ◽  
P Rat

scholarly journals Extended Amygdala to Ventral Tegmental Area Corticotropin-Releasing Factor Circuit Controls Binge Ethanol Intake

2017 ◽  
Vol 81 (11) ◽  
pp. 930-940 ◽  
Author(s):  
Jennifer A. Rinker ◽  
S. Alex Marshall ◽  
Christopher M. Mazzone ◽  
Emily G. Lowery-Gionta ◽  
Varun Gulati ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Ethanol Intake ◽  
Corticotropin Releasing Factor ◽  
Extended Amygdala ◽  
Ventral Tegmental ◽  
Binge Ethanol

scholarly journals Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption

2012 ◽  
Vol 102 (2) ◽  
pp. 275-285 ◽  
Author(s):  
William J. McBride ◽  
Mark W. Kimpel ◽  
Jeanette N. McClintick ◽  
Zheng-Ming Ding ◽  
Petri Hyytia ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ventral Tegmental Area ◽  
Ethanol Consumption ◽  
Ventral Tegmental
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