scholarly journals Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test

2016 ◽  
Vol 15 (6) ◽  
pp. 588-603 ◽  
Author(s):  
A. E. Arrant ◽  
A. J. Filiano ◽  
B. A. Warmus ◽  
A. M. Hall ◽  
E. D. Roberson
Keyword(s):  
Social Dominance ◽  
Tube Test

scholarly journals Experiential contributions to social dominance in a rat model of fragile-X syndrome

2018 ◽  
Vol 285 (1880) ◽  
pp. 20180294 ◽  
Author(s):  
K. Saxena ◽  
J. Webster ◽  
A. Hallas-Potts ◽  
R. Mackenzie ◽  
P. A. Spooner ◽  
...  
Keyword(s):  
Rat Model ◽  
Social Dominance ◽  
Complex Dynamics ◽  
Social Withdrawal ◽  
Fragile X ◽  
Neurodevelopmental Disorder ◽  
Wild Type ◽  
Repeated Testing ◽  
Tube Test ◽  
Complex Picture

Social withdrawal is one phenotypic feature of the monogenic neurodevelopmental disorder fragile-X. Using a ‘knockout' rat model of fragile-X, we examined whether deletion of the Fmr1 gene that causes this condition would affect the ability to form and express a social hierarchy as measured in a tube test. Male fragile-X ‘knockout' rats living together could successfully form a social dominance hierarchy, but were significantly subordinate to wild-type animals in mixed group cages. Over 10 days of repeated testing, the fragile-X mutant rats gradually showed greater variance and instability of rank during their tube-test encounters. This affected the outcome of future encounters with stranger animals from other cages, with the initial phenotype of wild-type dominance lost to a more complex picture that reflected, regardless of genotype, the prior experience of winning or losing. Our findings offer a novel insight into the complex dynamics of social interactions between laboratory living groups of fragile-X and wild-type rats. Even though this is a monogenic condition, experience has an impact upon future interactions with other animals. Gene/environment interactions should therefore be considered in the development of therapeutics.

Role of early environmental enrichment on the social dominance tube test at adulthood in the rat

2017 ◽  
Vol 234 (22) ◽  
pp. 3321-3334 ◽  
Author(s):  
Wen-Yu Cao ◽  
Zhao-Lan Hu ◽  
Yang Xu ◽  
Wen-Juan Zhang ◽  
Fu-Lian Huang ◽  
...  
Keyword(s):  
Social Dominance ◽  
Environmental Enrichment ◽  
Tube Test ◽  
The Social

scholarly journals Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance

2018 ◽  
Author(s):  
Kira D. A. Rienecker ◽  
Alexander T. Chavasse ◽  
Kim Moorwood ◽  
Andrew Ward ◽  
Anthony R. Isles
Keyword(s):  
Social Dominance ◽  
Social Rank ◽  
Social Behaviors ◽  
Paternal Allele ◽  
Future Research ◽  
Dominance Behavior ◽  
Isolation Stress ◽  
Tube Test ◽  
Test Behavior ◽  
Dominance Strategies

ABSTRACTImprinted genes are highly expressed in monoaminergic regions of the midbrain and their functions in this area are thought to have an impact on mammalian social behaviors. One such imprinted gene is Grb10, of which the paternal allele is currently recognized as mediating social dominance behavior. However, there has been no detailed study of social dominance in Grb10+/p mice. Moreover, the original study examined tube-test behavior in isolated mice 10 months of age. Isolation testing favors more territorial and aggressive behaviors, and does not address social dominance strategies employed in group housing contexts. Furthermore, isolation stress impacts midbrain function and dominance related behavior, often through alterations in monoaminergic signaling. Thus, we undertook a systematic study of Grb10+/p social rank and dominance behavior within the cage group, using a number of convergent behavioral tests. We examined both male and female mice to account for sex differences, and tested cohorts aged 2, 6, and 10 months to examine any developments related to age. We found group-housed Grb10+/p mice do not show evidence of enhanced social dominance, but cages containing Grb10+/p and wildtype mice lacked the normal correlation between three different measures of social rank. Moreover, a separate study indicated isolation stress induced inconsistent changes in tube test behavior. Taken together, these data suggest future research on Grb10+/p mice should focus on on the stability of social behaviors, rather than dominance per se.

Social Dominance

1999 ◽  
Author(s):  
Jim Sidanius ◽  
Felicia Pratto
Keyword(s):  
Social Dominance

Exploring the Multidimensional Facets of Authoritarianism: Authoritarian Aggression and Social Dominance Orientation

2008 ◽  
Vol 67 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Stefano Passini
Keyword(s):  
Social Dominance ◽  
Factor Model ◽  
Three Dimensional ◽  
Social Dominance Orientation ◽  
Model Fit ◽  
Regression Analyses ◽  
One Dimensional ◽  
Confirmatory Factor ◽  
The One ◽  
Better Than

The relation between authoritarianism and social dominance orientation was analyzed, with authoritarianism measured using a three-dimensional scale. The implicit multidimensional structure (authoritarian submission, conventionalism, authoritarian aggression) of Altemeyer’s (1981, 1988) conceptualization of authoritarianism is inconsistent with its one-dimensional methodological operationalization. The dimensionality of authoritarianism was investigated using confirmatory factor analysis in a sample of 713 university students. As hypothesized, the three-factor model fit the data significantly better than the one-factor model. Regression analyses revealed that only authoritarian aggression was related to social dominance orientation. That is, only intolerance of deviance was related to high social dominance, whereas submissiveness was not.

Cooking the books: The effect of accountability and social dominance

2003 ◽  
Author(s):  
Kristin Smith-Crowe ◽  
Elizabeth Umphress ◽  
Arthur P. Brief ◽  
Ann E. Tenbrunsel ◽  
Julie Gee
Keyword(s):  
Social Dominance
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