scholarly journals EHMT1/EHMT2 in EMT, Cancer Stemness and Drug Resistance: Emerging Evidence and Mechanisms

FEBS Journal ◽  
2021 ◽  
Author(s):  
Alamelu Nachiyappan ◽  
Neelima Gupta ◽  
Reshma Taneja
Keyword(s):  
Drug Resistance ◽  
Cancer Stemness

scholarly journals Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells

2016 ◽  
Vol 49 (6) ◽  
pp. 2558-2568 ◽  
Author(s):  
Flaria El Khoury ◽  
Laurent Corcos ◽  
Stéphanie Durand ◽  
Brigitte Simon ◽  
Catherine Le Jossic-Corcos
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Cancer Stemness ◽  
Human Colon Cancer ◽  
Anticancer Drug Resistance ◽  
Human Colon Cancer Cells

scholarly journals A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/β-catenin signaling in breast cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (12) ◽  
pp. 14791-14802 ◽  
Author(s):  
Do Yeon Kim ◽  
Eun Young Park ◽  
EunSun Chang ◽  
Hyeok-Gu Kang ◽  
Yoonjin Koo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Protein Kinase ◽  
Target Protein ◽  
Cancer Stemness ◽  
Protein Kinase D1

scholarly journals miRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway

Oncogenesis ◽  
2017 ◽  
Vol 6 (5) ◽  
pp. e326-e326 ◽  
Author(s):  
S-L Tung ◽  
W-C Huang ◽  
F-C Hsu ◽  
Z-P Yang ◽  
T-H Jang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Resistance ◽  
Erk Pathway ◽  
Cancer Stemness

scholarly journals Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

2015 ◽  
Vol 25 (4) ◽  
pp. 234-240 ◽  
Author(s):  
Laetitia Seguin ◽  
Jay S. Desgrosellier ◽  
Sara M. Weis ◽  
David A. Cheresh
Keyword(s):  
Drug Resistance ◽  
Cancer Stemness

scholarly journals Abstract 1986: IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma

2018 ◽  
Author(s):  
Bowie Yik Ling Cheng ◽  
Doris Hoi Wing Leung ◽  
Eunice Yuen Ting Lau ◽  
Irene Oi Lin Ng ◽  
Kin Wah Lee
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Resistance ◽  
Signaling Cascade ◽  
Cancer Stemness

AMPK-Fyn Signaling Promotes Notch1 Stability to Potentiate Hypoxia-Induced Breast Cancer Stemness and Drug Resistance

2020 ◽  
Author(s):  
Mohini Lahiry ◽  
Saurav Kumar ◽  
Kishore Hari ◽  
Adithya K. Chedere ◽  
Mohit K. Jolly ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Stemness

scholarly journals LINC00963 Promotes Cancer Stemness, Metastasis, and Drug Resistance in Head and Neck Carcinomas via ABCB5 Regulation

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1073 ◽  
Author(s):  
Shiao-Pieng Lee ◽  
Pei-Ling Hsieh ◽  
Chih-Yuan Fang ◽  
Pei-Ming Chu ◽  
Yi-Wen Liao ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Oral Cancer ◽  
Colony Formation ◽  
Therapy Resistance ◽  
The Cancer Genome Atlas ◽  
Pcr Analysis ◽  
Cancer Stemness ◽  
Self Renewal ◽  
Oral Cancer Patients ◽  
Oral Cancer Cells

Accumulating studies have indicated that long non-coding RNAs (lncRNAs) participate in the regulation of cancer stem cells (CSCs), which are crucial in tumor initiation, metastasis, relapse, and therapy resistance. In the current study, RT-PCR analysis was employed to evaluate the expression of LINC00963 in tumor tissues and oral CSCs. Stemness phenotypes and the expression of CSCs markers in oral cancer cells transfected with sh-LINC00963 were examined. Our results showed that the expression of the lncRNA LINC00963 was up-regulated in oral cancer tissues and CSCs. We found that the downregulation of LINC00963 inhibited CSC hallmarks, such as migration, invasion and colony formation capacity. Moreover, suppression of LINC00963 reduced the activity of stemness marker ALDH1, the percentage of self-renewal, chemoresistance and the expression of multidrug-resistance transporter ABCB5. Most importantly, we demonstrated that knockdown of LINC00963 decreased self-renewal, invasion and colony formation ability via ABCB5. Analysis of TCGA (the Cancer Genome Atlas) datasets suggested that the level of LINC00963 was positively correlated with the expression of the cancer stemness markers (Sox2 and CD44) and drug resistance markers (ABCG2 and ABCB5). Altogether, our results showed that suppression of LINC00963 may be beneficial to inhibit chemoresistance and cancer relapse in oral cancer patients.

scholarly journals EMT‐associated microRNAs and their roles in cancer stemness and drug resistance

2021 ◽  
Author(s):  
Guangtao Pan ◽  
Yuhan Liu ◽  
Luorui Shang ◽  
Fangyuan Zhou ◽  
Shenglan Yang
Keyword(s):  
Drug Resistance ◽  
Cancer Stemness
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