scholarly journals A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/β-catenin signaling in breast cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (12) ◽  
pp. 14791-14802 ◽  
Author(s):  
Do Yeon Kim ◽  
Eun Young Park ◽  
EunSun Chang ◽  
Hyeok-Gu Kang ◽  
Yoonjin Koo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Protein Kinase ◽  
Target Protein ◽  
Cancer Stemness ◽  
Protein Kinase D1

Abstract 3121: Validation of protein kinase D1 as a prognostic factor and pharmacological target for the treatment of breast cancer

2017 ◽  
Author(s):  
Caroline Spasojevic ◽  
Marie Regairaz ◽  
Sophie Vacher ◽  
Franck Assayag ◽  
Jean Marc Ricort ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Prognostic Factor ◽  
Protein Kinase D1 ◽  
Pharmacological Target

scholarly journals Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells

2020 ◽  
Vol 10 ◽  
Author(s):  
Messaouda Merzoug-Larabi ◽  
Ilige Youssef ◽  
Ai Thu Bui ◽  
Christine Legay ◽  
Sophia Loiodice ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Bisphenol A ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Protein Kinase D1

scholarly journals Identification of the Novel Tumor Suppressor Role of FOCAD/miR-491-5p to Inhibit Cancer Stemness, Drug Resistance and Metastasis via Regulating RABIF/MMP Signaling in Triple Negative Breast Cancer

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2524
Author(s):  
Wei-Chieh Huang ◽  
Hsiang-Cheng Chi ◽  
Shiao-Lin Tung ◽  
Po-Ming Chen ◽  
Ya-Chi Shih ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Tumor Suppressor ◽  
Pulmonary Metastasis ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
High Expression ◽  
The Novel ◽  
Cancer Stemness

Triple negative breast cancer (TNBC) possesses poor prognosis mainly due to development of chemoresistance and lack of effective endocrine or targeted therapies. MiR-491-5p has been found to play a tumor suppressor role in many cancers including breast cancer. However, the precise role of miR-491-5p in TNBC has never been elucidated. In this study, we reported the novel tumor suppressor function of FOCAD/miR-491-5p in TNBC. High expression of miR-491-5p was found to be associated with better overall survival in breast cancer patients. We found that miR-491-5p could be an intronic microRNA processed form FOCAD gene. We are the first to demonstrate that both miR-491-5p and FOCAD function as tumor suppressors to inhibit cancer stemness, epithelial-mesenchymal transition, drug resistance, cell migration/invasion, and pulmonary metastasis etc. in TNBC. MiR-491-5p was first reported to directly target Rab interacting factor (RABIF) to downregulate RABIF-mediated TNBC cancer stemness, drug resistance, cell invasion, and pulmonary metastasis via matrix metalloproteinase (MMP) signaling. High expression of RABIF was found to be correlated with poor clinical outcomes of breast cancer and TNBC patients. Our data indicated that miR-491-5p and RABIF are potential prognostic biomarkers and targeting the novel FOCAD/miR-491-5p/RABIF/MMP signaling pathway could serve as a promising strategy in TNBC treatment.

Sign in / Sign up

Export Citation Format

Share Document