scholarly journals Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications

FEBS Journal ◽  
2021 ◽  
Author(s):  
Takeshi Chujo ◽  
Kazuhito Tomizawa
Keyword(s):  
Transfer Rna ◽  
Rna Modifications

scholarly journals Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana

2010 ◽  
Vol 10 (1) ◽  
pp. 201 ◽  
Author(s):  
Peng Chen ◽  
Gunilla Jäger ◽  
Bo Zheng
Keyword(s):  
Arabidopsis Thaliana ◽  
Transfer Rna ◽  
Rna Modifications

scholarly journals Abundances of transfer RNA modifications and transcriptional levels for tRNA-modifying enzymes are sex-specific in mosquitoes

2021 ◽  
Author(s):  
Melissa Kelley ◽  
Melissa R Uhran ◽  
Cassandra Herbert ◽  
George Yoshida ◽  
Emmarie Watts ◽  
...  
Keyword(s):  
Mosquito Species ◽  
Critical Factor ◽  
Transfer Rna ◽  
Trna Modification ◽  
Rna Modifications ◽  
Transcript Levels ◽  
Trna Modifications ◽  
Remediation Strategies ◽  
Adapter Molecule ◽  
Novel Target

As carriers of multiple human diseases, understanding the mechanisms behind mosquito reproduction may have implications for remediation strategies. Transfer RNA (tRNA) acts as the adapter molecule of amino acids and are key components in protein synthesis and a critical factor in the function of tRNAs is chemical modifications. Here, we provide an assessment of tRNA modifications between sexes for three mosquito species and examine correlated transcript levels underlying key proteins involved in tRNA modification. Thirty-three tRNA modifications were detected among mosquito species and most of these modifications are higher in females compared to males. Analysis of previous male and female RNAseq datasets indicated a similar increase in tRNA modifying enzymes in females, supporting our observed female enrichment of tRNA modifications. Tissues-specific expressional studies revealed high transcript levels for tRNA modifying enzymes in the ovaries for Aedes aegypti, but not male reproductive tissues. These studies suggest that tRNA modifications may be critical to reproduction in mosquitoes, representing a potential novel target for control.

scholarly journals Lost in Translation: Defects in Transfer RNA Modifications and Neurological Disorders

2017 ◽  
Vol 10 ◽  
Author(s):  
Andrea Bednářová ◽  
Marley Hanna ◽  
Isabella Durham ◽  
Tara VanCleave ◽  
Alexis England ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Transfer Rna ◽  
Rna Modifications ◽  
Lost In Translation
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