scholarly journals Why cells need intramembrane proteases - a mechanistic perspective

FEBS Journal ◽  
2016 ◽  
Vol 283 (10) ◽  
pp. 1837-1845 ◽  
Author(s):  
Kvido Strisovsky
Keyword(s):  
Intramembrane Proteases

BIOCHEMISTRY: Intramembrane Proteases--Mixing Oil and Water

Science ◽  
2002 ◽  
Vol 296 (5576) ◽  
pp. 2156-2157 ◽  
Author(s):  
M. S. Wolfe
Keyword(s):  
Intramembrane Proteases

scholarly journals The Intramembrane Proteases Signal Peptide Peptidase-Like 2a and 2b Have Distinct Functions In Vivo

2014 ◽  
Vol 34 (8) ◽  
pp. 1398-1411 ◽  
Author(s):  
J. Schneppenheim ◽  
S. Huttl ◽  
T. Mentrup ◽  
R. Lullmann-Rauch ◽  
M. Rothaug ◽  
...  
Keyword(s):  
Signal Peptide ◽  
Signal Peptide Peptidase ◽  
Intramembrane Proteases

scholarly journals Latest emerging functions of SPP/SPPL intramembrane proteases

2017 ◽  
Vol 96 (5) ◽  
pp. 372-382 ◽  
Author(s):  
Torben Mentrup ◽  
Regina Fluhrer ◽  
Bernd Schröder
Keyword(s):  
Intramembrane Proteases

Chemical Tools for the Study of Intramembrane Proteases

2015 ◽  
Vol 10 (11) ◽  
pp. 2423-2434 ◽  
Author(s):  
Minh T. N. Nguyen ◽  
Tim Van Kersavond ◽  
Steven H. L. Verhelst
Keyword(s):  
Intramembrane Proteases ◽  
Chemical Tools

Substrate processing in intramembrane proteolysis by γ-secretase – the role of protein dynamics

2017 ◽  
Vol 398 (4) ◽  
pp. 441-453 ◽  
Author(s):  
Dieter Langosch ◽  
Harald Steiner
Keyword(s):  
Transmembrane Helix ◽  
Peptide Bond ◽  
Common Denominator ◽  
Transmembrane Helices ◽  
Intramembrane Proteases ◽  
Bond Scission ◽  
Catalytic Sites ◽  
Substrate Processing

Abstract Intramembrane proteases comprise a number of different membrane proteins with different types of catalytic sites. Their common denominator is cleavage within the plane of the membrane, which usually results in peptide bond scission within the transmembrane helices of their substrates. Despite recent progress in the determination of high-resolution structures, as illustrated here for the γ-secretase complex and its substrate C99, it is still unknown how these enzymes function and how they distinguish between substrates and non-substrates. In principle, substrate/non-substrate discrimination could occur at the level of substrate binding and/or cleavage. Focusing on the γ-secretase/C99 pair, we will discuss recent observations suggesting that global motions within a substrate transmembrane helix may be much more important for defining a substrate than local unraveling at cleavage sites.

How intramembrane proteases bury hydrolytic reactions in the membrane

Nature ◽  
2009 ◽  
Vol 459 (7245) ◽  
pp. 371-378 ◽  
Author(s):  
Elinor Erez ◽  
Deborah Fass ◽  
Eitan Bibi
Keyword(s):  
Intramembrane Proteases

scholarly journals A combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor

2021 ◽  
Author(s):  
Claudia Bohg ◽  
Carl Öster ◽  
Tillmann Utesch ◽  
Susanne Bischoff ◽  
Sascha Lange ◽  
...  
Keyword(s):  
Solid State ◽  
Protease Inhibitor ◽  
Solid State Nmr ◽  
Md Simulations ◽  
Binding Mode ◽  
Selective Inhibitors ◽  
Intramembrane Proteolysis ◽  
Rhomboid Protease ◽  
Intramembrane Proteases ◽  
Pharmacological Targets

Intramembrane proteolysis plays a fundamental role in many biological and pathological processes. Intramembrane proteases thus represent promising pharmacological targets, but few selective inhibitors have been identified. This is in contrast...

scholarly journals New insight into plant intramembrane proteases

2017 ◽  
Author(s):  
Małgorzata Adamiec ◽  
Lucyna Misztal ◽  
Robert Luciński
Keyword(s):  
Protein Turnover ◽  
Higher Plants ◽  
Protein Sequences ◽  
Higher Plant ◽  
Aspartic Proteases ◽  
Phylogenetic Relations ◽  
Intramembrane Proteases ◽  
Rhomboid Proteases ◽  
Zinc Metalloproteases ◽  
Insight Into

ABSTRACTThe process of proteolysis is a factor involved in control of the proper development of the plant and its responses to a changeable environment. Recent research has shown that proteases are not only engaged in quality control and protein turnover processes but also participate in the process which is known as regulated membrane proteolysis (RIP). Four families of integral membrane proteases, belonging to three different classes, have been identified: serine intramembrane proteases known as rhomboid proteases, site-2 proteases belonging to zinc metalloproteases, and two families of aspartic proteases: presenilins and signal peptide peptidases. The studies concerning intramembrane proteases in higher plants are, however, focused on Arabidopsis thaliana. The aim of the study was to identify and retrieve protein sequences of intramembrane protease homologs from other higher plant species and perform a detailed analysis of their primary sequences as well as their phylogenetic relations. This approach allows us to indicate several previously undescribed issues which may provide important directions for further research.

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